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alovudine and HIV

alovudine has been researched along with HIV in 13 studies

*HIV: Human immunodeficiency virus. A non-taxonomic and historical term referring to any of two species, specifically HIV-1 and/or HIV-2. Prior to 1986, this was called human T-lymphotropic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV). From 1986-1990, it was an official species called HIV. Since 1991, HIV was no longer considered an official species name; the two species were designated HIV-1 and HIV-2. [MeSH]

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (30.77)	18.7374
1990's	8 (61.54)	18.2507
2000's	1 (7.69)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Balzarini, J; Bergstrom, DE; De Clercq, E; Mott, AW; Swartling, DJ	1
Baba, M; Balzarini, J; De Clercq, E; Herdewijn, P; Janssen, G; Pauwels, R; Van Aerschot, A	1
Baba, M; Balzarini, J; Broder, S; De Clercq, E; Herdewijn, P; Pauwels, R; Vanderhaeghe, H	1
Bravo, ML; Cotte, L; Dorléacq, N; Ghosn, J; Harmenberg, J; Katlama, C; Mårdh, G; Mayers, D; Piketty, C; Quinson, AM; Sabo, N; Valdez, H	1
Armstrong, D; Barditch-Crovo, PA; Baron, PA; Duncanson, F; Flexner, C; Ganes, D; Jacobson, MA; Petty, BG; Powderly, W; van der Horst, C	1
Faraj, A; Gosselin, G; Imbach, JL; Perigaud, C; Schinazi, RF; Sommadossi, JP; Xie, MY	1
Eriksson, S; Karlsson, A; Oberg, B; Olofsson, S	1
Armstrong, D; Chou, TC; Kong, XB; Lang, SA; Muchmore, E; Ostrander, M; Polsky, B; Vidal, PM; Watanabe, KA; Zhu, QY	1
Cox, S; Harmenberg, J; Koshida, R; Wahren, B	1
Balzarini, J; Blaton, N; De Clercq, E; De Ranter, C; Everaert, D; Gosselin, G; Herdewijn, P; Imbach, JL; Peeters, O; Van Aerschot, A	1
Camerman, A; Camerman, N; Mastropaolo, D	1
Balzarini, J; De Clercq, E; Johns, DG; Matthes, E; Meeus, P	1
Langen, P; Lehmann, C; Matthes, E; Rosenthal, HA; Scholz, D	1

Trials

2 trial(s) available for alovudine and HIV

Article	Year
Antiviral activity of low-dose alovudine in antiretroviral-experienced patients: results from a 4-week randomized, double-blind, placebo-controlled dose-ranging trial. HIV medicine, 2007, Volume: 8, Issue:3 Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Double-Blind Method; Female; HIV; HIV Infections; Humans; Male; Middle Aged; RNA, Viral; Viral Load	2007
Relationship between plasma concentrations of 3'-deoxy-3'-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials. The Journal of infectious diseases, 1994, Volume: 170, Issue:6 Topics: Adult; Aged; Antiviral Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; HIV; HIV Core Protein p24; HIV Infections; Humans; Male; Middle Aged; Prospective Studies	1994

Article

Year

Antiviral activity of low-dose alovudine in antiretroviral-experienced patients: results from a 4-week randomized, double-blind, placebo-controlled dose-ranging trial.

HIV medicine, 2007, Volume: 8, Issue:3

Topics: Adult; Aged; Anti-HIV Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Double-Blind Method; Female; HIV; HIV Infections; Humans; Male; Middle Aged; RNA, Viral; Viral Load

2007

Relationship between plasma concentrations of 3'-deoxy-3'-fluorothymidine (alovudine) and antiretroviral activity in two concentration-controlled trials.

The Journal of infectious diseases, 1994, Volume: 170, Issue:6

Topics: Adult; Aged; Antiviral Agents; CD4 Lymphocyte Count; Dideoxynucleosides; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; HIV; HIV Core Protein p24; HIV Infections; Humans; Male; Middle Aged; Prospective Studies

1994

Other Studies

11 other study(ies) available for alovudine and HIV

Article	Year
3',3'-Difluoro-3'-deoxythymidine: comparison of anti-HIV activity to 3'-fluoro-3'-deoxythymidine. Journal of medicinal chemistry, 1992, Sep-04, Volume: 35, Issue:18 Topics: Antiviral Agents; Dideoxynucleosides; HIV; Molecular Conformation; Structure-Activity Relationship	1992
Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides. Journal of medicinal chemistry, 1988, Volume: 31, Issue:10 Topics: Animals; Antiviral Agents; Cell Line; Cytopathogenic Effect, Viral; HIV; Magnetic Resonance Spectroscopy; Purine Nucleosides; Pyrimidine Nucleosides; Structure-Activity Relationship; Virus Replication; Zidovudine	1988
3'-substituted 2',3'-dideoxynucleoside analogues as potential anti-HIV (HTLV-III/LAV) agents. Journal of medicinal chemistry, 1987, Volume: 30, Issue:8 Topics: Antiviral Agents; Cell Line; Chemical Phenomena; Chemistry; Cytopathogenic Effect, Viral; Deoxyribonucleosides; HIV; Humans; Structure-Activity Relationship; T-Lymphocytes; Virus Replication	1987
Selective protection of toxicity of 2',3'-dideoxypyrimidine nucleoside analogs by beta-D-uridine in human granulocyte-macrophage progenitor cells. Antiviral research, 1996, Volume: 29, Issue:2-3 Topics: Antiviral Agents; Bone Marrow Cells; Cells, Cultured; Dideoxynucleosides; Granulocytes; Hematopoietic Stem Cells; HIV; Humans; Macrophages; Molecular Structure; Uridine; Zidovudine	1996
The HIV replication inhibitor 3'-fluoro-3'-deoxythymidine blocks sialylation of N-linked oligosaccharides. Antiviral research, 1992, Jul-01, Volume: 19, Issue:1 Topics: Antibodies, Monoclonal; Antibodies, Viral; Antiviral Agents; Chromatography, High Pressure Liquid; Dideoxynucleosides; HIV; Oligosaccharides; Sialic Acids; Simplexvirus; Thymidine Kinase; Viral Envelope Proteins; Virus Replication	1992
Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine. Antimicrobial agents and chemotherapy, 1992, Volume: 36, Issue:4 Topics: Animals; Antiviral Agents; Cell Membrane Permeability; Cells, Cultured; Chromatography, High Pressure Liquid; Dideoxynucleosides; Female; HIV; Humans; Macaca fascicularis; Male; Tritium; Zidovudine	1992
Synergistic combinations and peptides in the inhibition of human immunodeficiency virus. Advances in enzyme regulation, 1991, Volume: 31 Topics: Alpha-Globulins; Amino Acid Sequence; Antiviral Agents; Cell Line; Dideoxynucleosides; Drug Synergism; Foscarnet; HIV; Humans; Molecular Sequence Data; Oligopeptides; Phosphonoacetic Acid; Proteins; Reverse Transcriptase Inhibitors; Serine Proteinase Inhibitors; Virus Replication; Zidovudine	1991
2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside. Antiviral research, 1990, Volume: 14, Issue:6 Topics: Antiviral Agents; Crystallography; Dideoxynucleosides; HIV; Humans; In Vitro Techniques; Molecular Structure; Structure-Activity Relationship; Virus Replication; X-Ray Diffraction; Zidovudine	1990
Structure of the anti-human immunodeficiency virus agent 3'-fluoro-3'-deoxythymidine and electronic charge calculations for 3'-deoxythymidines. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:9 Topics: Antiviral Agents; Dideoxynucleosides; HIV; Hydrogen Bonding; Molecular Conformation; Molecular Structure; Thymidine	1990
The antiretroviral and cytostatic activity, and metabolism of 3'-azido-2',3'-dideoxythymidine, 3'-fluoro-2',3'-dideoxythymidine and 2',3'-dideoxycytidine are highly cell type-dependent. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: Antiviral Agents; Cell Division; Cell Line; Dideoxynucleosides; HIV; Humans; Virus Replication; Zalcitabine; Zidovudine	1989
Phosphorylation, anti-HIV activity and cytotoxicity of 3'-fluorothymidine. Biochemical and biophysical research communications, 1988, Jun-16, Volume: 153, Issue:2 Topics: Animals; Antiviral Agents; Cell Division; Cell Line; Cell Survival; Cytidine Diphosphate; Cytopathogenic Effect, Viral; Dideoxynucleosides; HIV; Humans; Mice; Phosphorylation; Rats; Thymidine; Virus Replication; Zidovudine	1988