alosetron has been researched along with Disease Models, Animal in 12 studies
alosetron : A pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a potent serotonin 3 (5-HT(3)) receptor antagonist, and other anti-irritable bowel syndrome agents in this model." | 7.74 | Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats. ( Akuzawa, S; Funatsu, T; Hirata, T; Keto, Y; Sasamata, M; Takeuchi, A, 2007) |
| "The aim of this study was to establish a pathophysiologic model of irritable bowel syndrome, and then to evaluate the pharmaceutical efficacy of ramosetron, a potent serotonin 3 (5-HT(3)) receptor antagonist, and other anti-irritable bowel syndrome agents in this model." | 3.74 | Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats. ( Akuzawa, S; Funatsu, T; Hirata, T; Keto, Y; Sasamata, M; Takeuchi, A, 2007) |
| "Alosetron was also efficacious in stress-induced defecation and visceral pain models at 1 and 10 mg/kg, respectively." | 1.56 | Pharmacological evaluation of a novel corticotropin-releasing factor 1 receptor antagonist T-3047928 in stress-induced animal models in a comparison with alosetron. ( Aso, K; Itomi, Y; Kawamura, T; Kojima, T; Matsumoto-Okano, S; Matsushita, K; Tanaka, T; Tsukimi, Y, 2020) |
| "Visceral pain was measured by visceromotor response to colorectal distension, and the effects of alosetron and duloxetine on visceral pain were investigated in SART rats." | 1.42 | Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients. ( Itomi, Y; Kawamura, T; Tsukimi, Y, 2015) |
| "Visceral hyperalgesia was observed on day 7 but not on day 4." | 1.38 | Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice. ( Horie, S; Hosoya, T; Lo, MW; Matsumoto, K; Murayama, T; Takayama, H; Tashima, K, 2012) |
| "Alosetron (Lotronex) is a serotonin subtype 3 (5-HT3) receptor antagonist that alleviates symptoms of irritable bowel syndrome (IBS) in female patients." | 1.31 | Effects of alosetron on spontaneous migrating motor complexes in murine small and large bowel in vitro. ( Bush, TG; Sanders, KM; Smith, TK; Spencer, NJ; Watters, N, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 6 (50.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Manning, DD | 2 |
| Cioffi, CL | 1 |
| Usyatinsky, A | 1 |
| Fitzpatrick, K | 1 |
| Masih, L | 2 |
| Guo, C | 2 |
| Zhang, Z | 2 |
| Choo, SH | 2 |
| Sikkander, MI | 1 |
| Ryan, KN | 2 |
| Naginskaya, J | 2 |
| Hassler, C | 1 |
| Dobritsa, S | 1 |
| Wierschke, JD | 2 |
| Earley, WG | 2 |
| Butler, AS | 1 |
| Brady, CA | 2 |
| Barnes, NM | 2 |
| Cohen, ML | 1 |
| Guzzo, PR | 2 |
| Newman, AS | 1 |
| Itomi, Y | 2 |
| Tanaka, T | 1 |
| Matsushita, K | 1 |
| Kawamura, T | 2 |
| Kojima, T | 1 |
| Aso, K | 1 |
| Matsumoto-Okano, S | 1 |
| Tsukimi, Y | 2 |
| El-Ayache, N | 1 |
| Galligan, JJ | 1 |
| Morgan, B | 1 |
| Matsumoto, K | 1 |
| Lo, MW | 1 |
| Hosoya, T | 1 |
| Tashima, K | 1 |
| Takayama, H | 1 |
| Murayama, T | 1 |
| Horie, S | 1 |
| Mori, T | 1 |
| Kawano, K | 1 |
| Shishikura, T | 1 |
| Funatsu, T | 1 |
| Takeuchi, A | 1 |
| Hirata, T | 1 |
| Keto, Y | 1 |
| Akuzawa, S | 1 |
| Sasamata, M | 1 |
| Rudd, JA | 1 |
| Naylor, RJ | 1 |
| Pappas, TN | 1 |
| Mangel, AW | 1 |
| Lawson, C | 1 |
| Bush, TG | 1 |
| Spencer, NJ | 1 |
| Watters, N | 1 |
| Sanders, KM | 1 |
| Smith, TK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Duodenal Microbiome in Pediatric Functional Dyspepsia[NCT02340312] | 40 participants (Actual) | Observational | 2015-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alosetron and Disease Models, Animal
| Article | Year |
|---|---|
Review article: evaluation of drugs in experimental gut distension models.
Topics: Abdominal Pain; Animals; Carbolines; Colonic Diseases, Functional; Disease Models, Animal; Dogs; Ser | 1999 |
11 other studies available for alosetron and Disease Models, Animal
| Article | Year |
|---|---|
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Topics: Animals; Cell Line; Disease Models, Animal; Humans; Imidazoles; Indoles; Irritable Bowel Syndrome; M | 2011 |
The discovery of diazepinone-based 5-HT3 receptor partial agonists.
Topics: Administration, Oral; Animals; Azepines; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2014 |
Pharmacological evaluation of a novel corticotropin-releasing factor 1 receptor antagonist T-3047928 in stress-induced animal models in a comparison with alosetron.
Topics: Adrenocorticotropic Hormone; Animals; Carbolines; Conditioning, Classical; Defecation; Disease Model | 2020 |
5-HT
Topics: Animals; Carbolines; Disease Models, Animal; Humans; Hyperalgesia; Hypersensitivity; Irritable Bowel | 2019 |
Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients.
Topics: Abdominal Pain; Animals; Carbolines; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochlor | 2015 |
Drug development: A healthy pipeline.
Topics: Animals; Benzimidazoles; Benzofurans; Bile Acids and Salts; Carbolines; Colesevelam Hydrochloride; C | 2016 |
Experimental colitis alters expression of 5-HT receptors and transient receptor potential vanilloid 1 leading to visceral hypersensitivity in mice.
Topics: Animals; Carbolines; Dextran Sulfate; Disease Models, Animal; Electromyography; Hyperalgesia; Inflam | 2012 |
5-HT3-receptor antagonist inhibits visceral pain differently in chemical and mechanical stimuli in rats.
Topics: Animals; Carbolines; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Glycerol; Male | 2004 |
Effect of ramosetron on conditioned emotional stress-induced colonic dysfunction as a model of irritable bowel syndrome in rats.
Topics: Animals; Behavior, Animal; Benzimidazoles; Carbazoles; Carbolines; Colon; Colonic Diseases, Function | 2007 |
Effects of 5-HT3 receptor antagonists on models of acute and delayed emesis induced by cisplatin in the ferret.
Topics: Animals; Carbolines; Cisplatin; Disease Models, Animal; Emetics; Ferrets; Ondansetron; Serotonin Ant | 1994 |
Effects of alosetron on spontaneous migrating motor complexes in murine small and large bowel in vitro.
Topics: Animals; Carbolines; Colon; Colonic Diseases, Functional; Disease Models, Animal; Dose-Response Rela | 2001 |