alosetron has been researched along with Colitis in 6 studies
alosetron : A pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alosetron is a potent and selective serotonin antagonist that recently became the first Food and Drug Administration-approved agent for diarrhea-predominant IBS." | 5.31 | Ischemic colitis during treatment with alosetron. ( Fisher, RS; Friedel, D; Thomas, R, 2001) |
| " Reports of ischaemic colitis led to restricted use of the approved drug, alosetron." | 4.84 | Is there an experimental basis for the development of ischaemic colitis as a result of 5-HT3 antagonist treatment? ( Camilleri, M, 2007) |
| "As the use of the 5-HT(3) receptor antagonist alosetron (GlaxoSmithKline) and the 5-HT(4) receptor agonist tegaserod (Novartis) in patients with irritable bowel syndrome has been associated with cases of ischaemic colitis, the effects of alosetron, cilansetron (Solvay) and tegaserod on the rat splanchnic circulation were evaluated." | 3.75 | Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats. ( Holzer, P; Painsipp, E; Shahbazian, A, 2009) |
| " In male Sprague-Dawley rats recovered from acetic acid-induced colitis, we monitored visceral nociceptive response by scoring the abdominal withdrawal reflex and simultaneously measuring the changes in arterial pulse rate." | 3.74 | Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats. ( Choi, YD; Kim, HJ; Kim, TW; La, JH; Sung, TS; Yang, IS, 2008) |
| "Alosetron is a potent and selective serotonin antagonist that recently became the first Food and Drug Administration-approved agent for diarrhea-predominant IBS." | 1.31 | Ischemic colitis during treatment with alosetron. ( Fisher, RS; Friedel, D; Thomas, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dance, A | 1 |
| Painsipp, E | 1 |
| Shahbazian, A | 1 |
| Holzer, P | 1 |
| Camilleri, M | 1 |
| Grundy, D | 1 |
| McLean, P | 1 |
| Stead, R | 1 |
| Choi, YD | 1 |
| Sung, TS | 1 |
| Kim, HJ | 1 |
| La, JH | 1 |
| Kim, TW | 1 |
| Yang, IS | 1 |
| Friedel, D | 1 |
| Thomas, R | 1 |
| Fisher, RS | 1 |
1 review available for alosetron and Colitis
| Article | Year |
|---|---|
Is there an experimental basis for the development of ischaemic colitis as a result of 5-HT3 antagonist treatment?
Topics: Carbolines; Colitis; Diarrhea; Humans; Ischemia; Risk Factors; Serotonin 5-HT3 Receptor Antagonists; | 2007 |
5 other studies available for alosetron and Colitis
| Article | Year |
|---|---|
Transit time.
Topics: Anti-Bacterial Agents; Biofeedback, Psychology; Carbolines; Colitis; Diet; Dysentery; Dyspepsia; Egy | 2016 |
Alosetron, cilansetron and tegaserod modify mesenteric but not colonic blood flow in rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Carbazoles; Carbolines; Clonidine; Colitis; Colo | 2009 |
Impact of 5-HT3 receptor blockade on colonic haemodynamic responses to ischaemia and reperfusion in the rat.
Topics: Acute Disease; Animals; Carbolines; Chronic Disease; Colitis; Colon; Enzyme Inhibitors; Hyperemia; M | 2007 |
Increased 5-hydroxytryptamine mediates post-inflammatory visceral hypersensitivity via the 5-hydroxytryptamine 3 receptor in rats.
Topics: 5-Hydroxytryptophan; Acetic Acid; Animals; Carbolines; Colitis; Granisetron; Hypersensitivity; Intes | 2008 |
Ischemic colitis during treatment with alosetron.
Topics: Carbolines; Colitis; Colonic Diseases, Functional; Colonoscopy; Humans; Ischemia; Male; Middle Aged; | 2001 |