allylpyrocatechol has been researched along with Malaria* in 1 studies
1 other study(ies) available for allylpyrocatechol and Malaria
| Article | Year |
|---|---|
Structure-Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle.
Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection "hot-spots," medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure-activity relationship was analyzed to disclose the crucial sub-structures for the potent activity. Topics: Animals; Antimalarials; Catechols; Disease Models, Animal; Malaria; Mice; Parasitic Sensitivity Tests; Piper betle; Plant Extracts; Plant Leaves; Plasmodium berghei; Structure-Activity Relationship | 2020 |