alloxan has been researched along with Insulinoma in 20 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we studied the effect of various prostaglandins (PGs) on alloxan-induced cytotoxicity to rat insulinoma (RIN) cells." | 7.72 | Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. ( Das, UN; Devi, MM, 2004) |
| " In the present study the cytotoxic effects of (i) alloxan alone, (ii) a combination of alloxan and cysteine or (iii) hydrogen peroxide were investigated in two established insulinoma cell lines (HIT-T15 and RINm5F), and compared with the effects on J-774 cells." | 7.69 | Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress. ( Brunk, U; Ollinger, K; Zhang, H, 1995) |
| "Alloxan-induced in vitro cytotoxicity and apoptosis in an insulin-secreting rat insulinoma cell line, RIN, was prevented by prior exposure of these cells to linoleic acid, gamma-linolenic acid, and arachidonic acid (AA) but not to dihomo-gamma-linolenic acid." | 3.72 | Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus: effect of omega-6 fatty acids. ( Das, UN; Suresh, Y, 2003) |
| "In the present study, we studied the effect of various prostaglandins (PGs) on alloxan-induced cytotoxicity to rat insulinoma (RIN) cells." | 3.72 | Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. ( Das, UN; Devi, MM, 2004) |
| " Here we show that alloxan-induced in vitro cytotoxicity and apoptosis in an insulin secreting rat insulinoma, RIN, cells can be prevented by arachidonic acid (AA) and that both cyclo-oxygenase and lipoxygenase inhibitors do not block this protective action." | 3.71 | Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. ( Das, UN; Suresh, Y, 2001) |
| " In the present study the cytotoxic effects of (i) alloxan alone, (ii) a combination of alloxan and cysteine or (iii) hydrogen peroxide were investigated in two established insulinoma cell lines (HIT-T15 and RINm5F), and compared with the effects on J-774 cells." | 3.69 | Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress. ( Brunk, U; Ollinger, K; Zhang, H, 1995) |
| " In the present study, we tested whether ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a glutathione peroxidase mimicking compound, could counteract the effects of IL-1 beta, H2O2 and alloxan in rat pancreatic islets and in the rat insulinoma cell line RINm5F (RIN cells)." | 3.69 | Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells. ( de-Mello, MA; Eizirik, DL; Flodström, M, 1996) |
| " Alloxan and its auto-oxidation product hydrogen peroxide (H2O2) irreversibly depolarize insulinoma cells by opening a non-selective cation channel." | 3.69 | Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1. ( Ashford, ML; Herson, PS, 1997) |
| "STZ (65 mg/kg)-induced type 2 diabetes mellitus animals showed reduced plasma BDNF and LXA4 levels (P < 0." | 1.51 | PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo. ( Bathina, S; Das, UN, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (35.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 6 (30.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bathina, S | 1 |
| Das, UN | 4 |
| Ramkumar, KM | 1 |
| Manjula, C | 1 |
| Sankar, L | 1 |
| Suriyanarayanan, S | 1 |
| Rajaguru, P | 1 |
| Suresh, Y | 2 |
| Picton, SF | 1 |
| McCluskey, JT | 1 |
| Flatt, PR | 3 |
| McClenaghan, NH | 1 |
| BECK, AM | 1 |
| KROOK, L | 1 |
| Devi, MM | 1 |
| Kikkawa, R | 1 |
| Haneda, M | 1 |
| Hatanaka, I | 1 |
| Yasuda, H | 1 |
| Shigeta, Y | 1 |
| Okuno, Y | 1 |
| Wada, M | 1 |
| Okamoto, H | 2 |
| Yamamoto, H | 2 |
| Zhang, H | 1 |
| Ollinger, K | 1 |
| Brunk, U | 1 |
| de-Mello, MA | 1 |
| Flodström, M | 1 |
| Eizirik, DL | 1 |
| Herson, PS | 1 |
| Ashford, ML | 1 |
| Driggers, WJ | 1 |
| Holmquist, GP | 1 |
| LeDoux, SP | 1 |
| Wilson, GL | 1 |
| Janjic, D | 2 |
| Maechler, P | 1 |
| Sekine, N | 1 |
| Bartley, C | 1 |
| Annen, AS | 1 |
| Wolheim, CB | 1 |
| Bloch, KO | 1 |
| Zemel, R | 1 |
| Bloch, OV | 1 |
| Grief, H | 1 |
| Vardi, P | 1 |
| Wollheim, CB | 1 |
| Shibier, O | 1 |
| Ioannides, C | 1 |
| Swanston-Flatt, SK | 2 |
| Yamagami, T | 1 |
| Miwa, A | 1 |
| Takasawa, S | 1 |
| Tan, KS | 1 |
| Marks, V | 1 |
| Meglasson, MD | 1 |
| Burch, PT | 1 |
| Berner, DK | 1 |
| Najafi, H | 1 |
| Matschinsky, FM | 1 |
20 other studies available for alloxan and Insulinoma
| Article | Year |
|---|---|
PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo.
Topics: Alloxan; Animals; Arachidonic Acid; Benzo(a)pyrene; Brain-Derived Neurotrophic Factor; Cell Death; C | 2019 |
Potential in vitro antioxidant and protective effects of Gymnema montanum H. on alloxan-induced oxidative damage in pancreatic beta-cells, HIT-T15.
Topics: Alloxan; Animals; Biphenyl Compounds; Cell Line, Tumor; Cell Survival; Cricetinae; Free Radical Scav | 2009 |
Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus: effect of omega-6 fatty acids.
Topics: Alloxan; Animals; Antioxidants; Apoptosis; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experi | 2003 |
Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells.
Topics: Alloxan; Animals; Apoptosis; Cell Line; Cytotoxins; Dose-Response Relationship, Drug; Hydrogen Perox | 2002 |
CANINE INSULOMA. TWO SURGICAL CASES WITH RELAPSES.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Dog Diseases; Dogs; Hypoglycemia; Insulinoma; Neoplasm Metast | 1965 |
Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Alloxan; Alprostadil; Animals; Antioxidants; Apoptosis; Bucladesine; C | 2004 |
Insulin release from BK virus-induced and in vitro maintained insulinoma cells of Syrian golden hamster.
Topics: Adenoma, Islet Cell; Alloxan; Animals; BK Virus; Bucladesine; Cricetinae; Cyclic AMP; Insulin; Insul | 1983 |
DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets--a new aspect to development of insulin-dependent diabetes and pancreatic B-cell tumors.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 1983 |
Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress.
Topics: Alloxan; Animals; Cell Survival; Cricetinae; Cysteine; Dose-Response Relationship, Drug; Hydrogen Pe | 1995 |
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells.
Topics: Alloxan; Animals; Antioxidants; Azoles; Cytokines; Humans; Hydrogen Peroxide; Insulin; Insulinoma; I | 1996 |
Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1.
Topics: Alloxan; Animals; Cell Polarity; Cysteine; Free Radical Scavengers; Hydrogen Peroxide; Insulinoma; I | 1997 |
Mapping frequencies of endogenous oxidative damage and the kinetic response to oxidative stress in a region of rat mtDNA.
Topics: Alloxan; Animals; Base Sequence; Cell Survival; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage; DN | 1997 |
Free radical modulation of insulin release in INS-1 cells exposed to alloxan.
Topics: Alloxan; Antioxidants; Butylated Hydroxyanisole; Calcium; Cell Survival; Dose-Response Relationship, | 1999 |
Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus.
Topics: Alloxan; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Cell Survival; Diabetes Mellitus, Exper | 2001 |
Streptozotocin and alloxan-based selection improves toxin resistance of insulin-producing RINm cells.
Topics: 3-O-Methylglucose; Alloxan; Analysis of Variance; Animals; Cell Division; Cell Survival; Drug Resist | 2000 |
Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay.
Topics: Alloxan; Animals; Cell Line; Cells, Cultured; Colorimetry; Glucose; Indicators and Reagents; Insulin | 1992 |
Studies on the chemical and immunological destruction of insulin-secreting islet cell tumours.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Blood Glucose; Cell Line; Insulin; Insulinoma; Male; Pancreat | 1989 |
Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors.
Topics: Adenoma, Islet Cell; Alloxan; Amides; Animals; Insulinoma; Male; NAD+ Nucleosidase; Niacinamide; Pan | 1985 |
Effects of cytotoxic drugs and inhibitors of insulin secretion on a serially transplantable rat insulinoma and cultured rat insulinoma cells.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Insuli | 1987 |
Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell.
Topics: Alloxan; Animals; Glucokinase; In Vitro Techniques; Insulinoma; Islets of Langerhans; Kinetics; Live | 1986 |