alloxan and Hyperglycemia studies

Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.

Research Excerpts

Excerpt	Relevance	Reference
"Our experimental results indicate that taxifolin alleviates alloxan-induced hyperglycemia-related neuropathy and neuropathic pain."	8.12	The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation. ( Alay, M; Altuner, D; Atmaca, M; Bulut, S; Coban, A; Sakin, A; Sonmez, MG; Suleyman, B; Suleyman, H; Yazici, GN, 2022)
" Don for potential anti-diabetic activity in the in vivo mouse model of alloxan-induced hyperglycemia."	8.12	Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G. Don against alloxan-induced in vivo hyperglycemia model. ( Achyut, A; Amir, Z; Amna, N; Fazle, R; Irfan, U; Shafiq Ur, R, 2022)
" Several experimental groups were tested: (a) animals that were subjected to long-term (42-day) alloxan-hyperglycemia and protected with insulin, (b) healthy animals that received a low dose of insulin that does not produce changes in glycemia, and (c) animals that received long-term treatment with fluoxetine."	7.91	Responsivity of lateral septum-mPFC connections in alloxan-induced hyperglycemia. ( Contreras, CM; Gutiérrez-García, AG; Moreno-Cortés, ML, 2019)
" We investigated whether increases in the duration of hyperglycemia result in the development of corneal lesions in a mouse model of alloxan (AL)- or streptozotocin (STZ)-induced type 1 diabetes."	7.88	Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes. ( Matsuura, T; Ozaki, K; Terayama, Y, 2018)
"Alloxan induces oxidative stress and hyperglycemia in animal models."	7.83	Protective effect of vitamin E against alloxan-induced mouse hyperglycemia. ( Doi, W; Masuoka, N; Takemoto, K, 2016)
"From this study, we conclude that quercetin ameliorates hyperglycemia and oxidative stress, by blunting free radical induced toxicity in T2DM."	7.80	Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. ( Alam, MM; Meerza, D; Naseem, I, 2014)
"The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats."	7.80	The protective effect of vanadium against diabetic cataracts in diabetic rat model. ( Gao, XC; Han, Q; Mi, SY; Shi, DJ; Sun, L; Yu, Y, 2014)
"The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed."	7.79	Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013)
"We studied the dynamics of lipid peroxidation-antioxidant defense system in rat model of alloxan diabetes and compared it with disorders of carbohydrate and lipid metabolism."	7.79	Dynamics of lipid peroxidation-antioxidant defense system during alloxan diabetes in rats. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013)
"The present study examined the protective effects of taurine on alloxan-induced diabetic cataracts and lens damage in male New Zealand White rabbits."	7.78	Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits. ( Chen, YC; Chen, YY; Hsu, YW; Lin, SL; Tseng, JK; Yeh, SM, 2012)
"Our studies suggested the possibility of controlling hyperglycemia in alloxan induced diabetic mice by the stimulation of the hepatic insulin synthesis through the systemic stimulation of NO production in the hepatocytes."	7.78	The control of hyperglycemia in alloxan treated diabetic mice through the stimulation of hepatic insulin synthesis due to the production of nitric oxide. ( Ghosh, R; Jana, P; Sinha, AK, 2012)
"Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state."	7.77	Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011)
"The separate impacts of the chronic diabetic state and the prevailing hyperglycemia on plasma substrates and hormones, in vivo glucose turnover, and ex vivo skeletal muscle (SkM) during exercise were examined in the same six dogs before alloxan-induced diabetes (prealloxan) and after 4-5 wk of poorly controlled hyperglycemic diabetes (HGD) in the absence and presence of approximately 300-min phlorizin-induced (glycosuria mediated) normoglycemia (NGD)."	7.73	Prevailing hyperglycemia is critical in the regulation of glucose metabolism during exercise in poorly controlled alloxan-diabetic dogs. ( Alford, FP; Christopher, MJ; Kemp, BE; McConell, G; Rantzau, C, 2005)
"The effect exerted by hyperglycemia on the analgesic potential of morphine was studied in female Wistar rats with the hotplate device and the formalin test."	7.73	Effect of hyperglycemia on the efficacy of morphine analgesia in rats. ( Ibironke, GF; Saba, OJ, 2006)
"Ten weeks of hyperglycemia in the alloxan induced diabetic rabbit was associated with a 14% decrease in corneal oxygen uptake, a 14% decrease in corneal epithelial ouabain-insensitive ATPase activity and no change in corneal epithelial ouabain-sensitive ATPase activity."	7.70	Oxygen consumption and ATPase activity in the corneal epithelium of rabbits with alloxan induced hyperglycemia. ( Herse, P; Petchell, M, 1998)
" We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan."	7.70	Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. ( Azuma, H; Goto, M; Masuda, H; Tamaoki, S, 1999)
" sativum) to alloxan induced diabetic (ALX-D) mice significantly lowered the serum glucose levels, nociceptive response in tail-flick, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test, over 28 days, thus, showing the reversal trend in hyperglycemia and hyperalgesia compared to ALX-D mice."	7.70	Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment. ( Kumar, GR; Reddy, KP, 1999)
" It did not modify the hyperglycemia induced by epinephrine (normal islet beta-cells) or alloxan (impaired islet beta-cells)."	7.70	Urethane-induced hyperglycemia. ( Du, ZJ; Fu, SX; Ren, LM; Wang, MY, 2000)
" We have used this model system to investigate whether 5 to 9 weeks of alloxan-induced hyperglycemia increases platelet adhesion and aggregation on a damaged vessel wall in vivo as well as platelet aggregation in vitro."	7.67	Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo. ( Ingerman-Wojenski, CM; Silver, MJ; Smith, M, 1987)
"The effects of peripheral venous and portal venous delivery of insulin by a closed-loop insulin infusion device (Biostator GCIIS) on postprandial hyperglycemia and rates of glucose appearance, disappearance, and clearance were compared in alloxan-diabetic dogs."	7.66	Effect of peripheral versus portal venous administration of insulin on postprandial hyperglycemia and glucose turnover in alloxan-diabetic dogs. ( Clemens, AH; Gerich, JE; Hall, LD; Haymond, MW; Patton, GS; Rizza, RA; Service, FJ; Westland, RE, 1981)
"In two studies for toxicity, cataracts occurred in beagle dogs given diazoxide daily in high doses."	7.65	Cataracts in beagle dogs given diazoxide. ( Field, WE; Schiavo, DM; Vymetal, FJ, 1975)
"Alloxan diabetic mice were treated with EGCG."	5.72	(-)-Epigallocatechin gallate (EGCG) pharmacokinetics and molecular interactions towards amelioration of hyperglycemia, hyperlipidemia associated hepatorenal oxidative injury in alloxan induced diabetic mice. ( Adnan, M; Badraoui, R; Ben-Nasr, H; Chappard, D; El-Feki, A; Gargouri, M; Kausar, MA; Magné, C; Saeed, M; Siddiqui, AJ; Snoussi, M; Soussi, A, 2022)
"Alloxan is a compound widely used in models of diabetes mellitus due to its ability for damage insulin-producing β-cells."	5.37	Inhibition of δ-aminolevulinate dehydratase is not closely related to the development of hyperglycemia in alloxan-induced diabetic mice. ( Barbosa, NB; Brito, VB; da Luz, SC; da Rocha, JB; de Carvalho, NR; Folmer, V; Puntel, GO, 2011)
"Pioglitazone treatment for 8 weeks affected GSH-Px activity in diabetic liver (261."	5.33	Effects of pioglitazone on hyperglycemia-induced alterations in antioxidative system in tissues of alloxan-treated diabetic animals. ( Gumieniczek, A, 2005)
"Alloxan treatment, however, does not alter lymph insulin kinetics, indicating that insulin resistance of Type 1 (insulin-dependent) diabetes mellitus reflects direct impairment at the cellular level."	5.30	Evidence for direct action of alloxan to induce insulin resistance at the cellular level. ( Ader, M; Bergman, RN; Richey, JM, 1998)
"Alloxan is a diabetogenic agent which apparently acts through formation of superoxide radicals formed by redox cycling."	5.30	Enhanced alloxan-induced beta-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase. ( Jonsson, LM; Marklund, SL; Sentman, ML, 1999)
"Therefore, it is inferred from the study that MFE can exert a protective effect by suppressing hyperglycemia and modulating oxidative stress and apoptosis in alloxan-administered diabetic mice."	4.31	Therapeutic Potential of ( Almutary, AG; Bhan, S; Bora, J; Haque, S; Hussain, A; Malik, S; Rustagi, S; Sadier, NS; Sahariah, P; Singh, N; Syiem, D, 2023)
" Group I acted as the control, whereas groups II, III, IV, and V were considered experimental groups which received a single dosage (150 mg/kg body weight) of alloxan (ALX) intraperitoneally (i."	4.12	Co-administration of ( Kar, A; Panda, S; Sharma, N; Yadav, D, 2022)
" Don for potential anti-diabetic activity in the in vivo mouse model of alloxan-induced hyperglycemia."	4.12	Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G. Don against alloxan-induced in vivo hyperglycemia model. ( Achyut, A; Amir, Z; Amna, N; Fazle, R; Irfan, U; Shafiq Ur, R, 2022)
"Our experimental results indicate that taxifolin alleviates alloxan-induced hyperglycemia-related neuropathy and neuropathic pain."	4.12	The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation. ( Alay, M; Altuner, D; Atmaca, M; Bulut, S; Coban, A; Sakin, A; Sonmez, MG; Suleyman, B; Suleyman, H; Yazici, GN, 2022)
" Several experimental groups were tested: (a) animals that were subjected to long-term (42-day) alloxan-hyperglycemia and protected with insulin, (b) healthy animals that received a low dose of insulin that does not produce changes in glycemia, and (c) animals that received long-term treatment with fluoxetine."	3.91	Responsivity of lateral septum-mPFC connections in alloxan-induced hyperglycemia. ( Contreras, CM; Gutiérrez-García, AG; Moreno-Cortés, ML, 2019)
" We investigated whether increases in the duration of hyperglycemia result in the development of corneal lesions in a mouse model of alloxan (AL)- or streptozotocin (STZ)-induced type 1 diabetes."	3.88	Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes. ( Matsuura, T; Ozaki, K; Terayama, Y, 2018)
" Hyperglycemia was induced by alloxan on Sprague Dawley rats."	3.88	Effect of Moringa oleifera consumption on diabetic rats. ( Guerrero-Quiroz, LA; López-de la Mora, DA; Nuño, K; Puebla-Mora, AG; Torres-Vitela, MR; Vázquez-Paulino, OD; Villarruel-López, A, 2018)
"This new study aimed to evaluate for the first time the effect of Cymodocea nodosa extract (CNE) on α-amylase activity, hyperglycemia and diabetes complications in the alloxan-induced diabetic rats."	3.85	Effects of Cymodocea nodosa extract on metabolic disorders and oxidative stress in alloxan-diabetic rats. ( Allouche, N; Belghith, H; Belghith, K; Ben Abdallah Kolsi, R; Ben Salah, H; Chaaben, R; El Feki, A; Jamoussi, K; Jardak, N; Rebai, T, 2017)
" Outcomes of normoglycemic studies reveals insignificant glucose lowering effects however hyperglycemic studies (glucose challenge and Alloxan inducted hyperglycemia) demonstrates significant glucose lowering effect of Aseel date especially with 300mg/kg dose."	3.85	Report - Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats. ( Afroz, S; Ahmed, S; Jamil, S; Khan, RA, 2017)
"Alloxan induces oxidative stress and hyperglycemia in animal models."	3.83	Protective effect of vitamin E against alloxan-induced mouse hyperglycemia. ( Doi, W; Masuoka, N; Takemoto, K, 2016)
"Alloxan is an environmental food contaminant that causes DNA damage in living cells and induces hyperglycemia."	3.83	Nanopharmaceutical approach using pelargonidin towards enhancement of efficacy for prevention of alloxan-induced DNA damage in L6 cells via activation of PARP and p53. ( Abraham, SK; Khuda-Bukhsh, AR; Samadder, A, 2016)
"From this study, we conclude that quercetin ameliorates hyperglycemia and oxidative stress, by blunting free radical induced toxicity in T2DM."	3.80	Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. ( Alam, MM; Meerza, D; Naseem, I, 2014)
"The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats."	3.80	The protective effect of vanadium against diabetic cataracts in diabetic rat model. ( Gao, XC; Han, Q; Mi, SY; Shi, DJ; Sun, L; Yu, Y, 2014)
"The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed."	3.79	Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013)
"We studied the dynamics of lipid peroxidation-antioxidant defense system in rat model of alloxan diabetes and compared it with disorders of carbohydrate and lipid metabolism."	3.79	Dynamics of lipid peroxidation-antioxidant defense system during alloxan diabetes in rats. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013)
"We established that alloxan diabetes leads to early development of diabetic encephalopathy on the background of marked hyperglycemia."	3.79	[Dynamics of initial manifestations of experimental diabetic encephalopathy]. ( Miroshnichenko, IIu; Rassokhina, LM; Volchegorskiĭ, IA, 2013)
"The purpose of this study was to investigate the effects of hyperglycemia on atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation (AF) in alloxan-induced diabetic rabbits."	3.78	Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Yang, W, 2012)
" We injected intraperitoneally alloxan (ALX) at the dose of 200 mg/kg body weight (bw) to induce hyperglycemia in mice and tested possible hypoglycemic effects of HD in vivo by deploying two doses (100 and 200 mg/kg bw, respectively)."	3.78	Antihyperglycemic potentials of a threatened plant, Helonias dioica: antioxidative stress responses and the signaling cascade. ( Chakraborty, D; Dutta, S; Khuda-Bukhsh, AR; Samadder, A, 2012)
"The present study examined the protective effects of taurine on alloxan-induced diabetic cataracts and lens damage in male New Zealand White rabbits."	3.78	Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits. ( Chen, YC; Chen, YY; Hsu, YW; Lin, SL; Tseng, JK; Yeh, SM, 2012)
"Our studies suggested the possibility of controlling hyperglycemia in alloxan induced diabetic mice by the stimulation of the hepatic insulin synthesis through the systemic stimulation of NO production in the hepatocytes."	3.78	The control of hyperglycemia in alloxan treated diabetic mice through the stimulation of hepatic insulin synthesis due to the production of nitric oxide. ( Ghosh, R; Jana, P; Sinha, AK, 2012)
"Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state."	3.77	Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011)
"This study aimed to evaluate the effect of a polysaccharide named levan, which was produced by new isolated bacteria, on oxidative stress and hyperglycemia in alloxan-induced diabetic rats."	3.77	Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. ( Belghith, H; Belghith, KS; Dahech, I; Feki, A; Hamden, K; Mejdoub, H, 2011)
" These extracts were tested for their free radical (FR) scavenging potential for different FR species, hypoglycemic potential on alloxan-induced hyperglycemia, and anti-inflammatory property in carrageenan-induced paw edema and lipopolysaccharide (LPS)-induced nitric oxide (NO) production in rat peritoneal macrophage culture."	3.77	Chemical characterization of various fractions of leaves of Cinnamomum tamala Linn toward their antioxidant, hypoglycemic, and anti-inflammatory property. ( Chaurasia, JK; Tripathi, YB, 2011)
"The effect exerted by hyperglycemia on the analgesic potential of morphine was studied in female Wistar rats with the hotplate device and the formalin test."	3.73	Effect of hyperglycemia on the efficacy of morphine analgesia in rats. ( Ibironke, GF; Saba, OJ, 2006)
"Alloxan-induced hyperglycemia was accompanied by activation of lipid peroxidation processes with different degree of their completeness depending on the age of experimental animals."	3.73	Age-related differences in the degree of lipid peroxidation and state of antioxidant protection under the influence of alloxan. ( Gvozdenko, TA; Yan'kova, VI, 2005)
"The separate impacts of the chronic diabetic state and the prevailing hyperglycemia on plasma substrates and hormones, in vivo glucose turnover, and ex vivo skeletal muscle (SkM) during exercise were examined in the same six dogs before alloxan-induced diabetes (prealloxan) and after 4-5 wk of poorly controlled hyperglycemic diabetes (HGD) in the absence and presence of approximately 300-min phlorizin-induced (glycosuria mediated) normoglycemia (NGD)."	3.73	Prevailing hyperglycemia is critical in the regulation of glucose metabolism during exercise in poorly controlled alloxan-diabetic dogs. ( Alford, FP; Christopher, MJ; Kemp, BE; McConell, G; Rantzau, C, 2005)
"Tangniaole Capsule was able to decrease the blood-sugar content in normal mice and rats, heighten the level of serum insulin and the content of liver glycogen in normal rats, decrease the blood-sugar content and increase the content of liver glycogen in hyperglycemina rats induced by adrenalin, inhibit the alloxan-induced hyperglycemia of mice and rats and improve the glucose tolerance of rats."	3.71	[Experimental study on the hypoglycemic effect of tangniaole capsule]. ( Han, S; Sun, G; Wang, R; Wang, Y, 2002)
"This study examined the changes in blood-brain barrier (BBB) permeability following acute aluminum (Al) exposure during acute and chronic hyperglycemia in rats."	3.71	Effect of aluminum on the blood-brain barrier permeability in acute and chronically hyperglycemic rats. ( Cevik, A; Elmas, I; Kalayci, RB; Kaya, M; Kücük, M, 2001)
"To compare the effect of hyperglycemia on corneal neovascularization (NV) induced by linoleic acid hydroperoxide (LHP) in a rabbit model."	3.71	Lipid hydroperoxide induced corneal neovascularization in hyperglycemic rabbits. ( Arai, Y; Armstrong, D; Fukuda, S; Higa, A; Kan, K; Koide, R; Nakanishi-Ueda, T; Tsuchiya, T; Ueda, T; Watanabe, K; Yasuhara, H, 2002)
" sativum) to alloxan induced diabetic (ALX-D) mice significantly lowered the serum glucose levels, nociceptive response in tail-flick, hotplate, allodynia, formalin test and relative thickness, weight of hind paw in formalin induced Paw oedema test, over 28 days, thus, showing the reversal trend in hyperglycemia and hyperalgesia compared to ALX-D mice."	3.70	Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment. ( Kumar, GR; Reddy, KP, 1999)
"Ten weeks of hyperglycemia in the alloxan induced diabetic rabbit was associated with a 14% decrease in corneal oxygen uptake, a 14% decrease in corneal epithelial ouabain-insensitive ATPase activity and no change in corneal epithelial ouabain-sensitive ATPase activity."	3.70	Oxygen consumption and ATPase activity in the corneal epithelium of rabbits with alloxan induced hyperglycemia. ( Herse, P; Petchell, M, 1998)
" We examined whether endogenous inhibitors of NO synthesis are involved in the augmentation of intimal hyperplasia in rabbits with hyperglycaemia induced by alloxan."	3.70	Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. ( Azuma, H; Goto, M; Masuda, H; Tamaoki, S, 1999)
" It did not modify the hyperglycemia induced by epinephrine (normal islet beta-cells) or alloxan (impaired islet beta-cells)."	3.70	Urethane-induced hyperglycemia. ( Du, ZJ; Fu, SX; Ren, LM; Wang, MY, 2000)
" Pretreatment with PBN (150 mg/kg ip) significantly reduced the severity of hyperglycemia in both alloxan- and streptozotocin (STZ) induced diabetes."	3.70	Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes. ( Bray, TM; Chen, G; Ho, E, 2000)
"Insulin receptor activity and its relationship with catecholamines and serotonin were investigated in rat whole brain membranes, synaptosomes and choroid plexus in alloxan induced short term and long term hyperglycemia and hyperinsulinemia."	3.68	Modulation of insulin receptors and catecholamines in rat brain in hyperglycemia and hyperinsulinemia. ( Azam, M; Baquer, NZ; Gupta, G, 1990)
" To investigate further the issue the effects of alloxan-induced hyperglycemia on the incidence and severity of haloperidol-induced perioral movements were studied in the rat."	3.68	Increased incidence of neuroleptic-induced perioral movements in the rat by hyperglycemia. ( Sandyk, R, 1990)
"Inhibition of pancreatic glucagon secretion during hyperglycemia could be mediated by (a) glucose, (b) insulin, (c) somatostatin, or (d) glucose in conjunction with insulin."	3.68	Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. ( Greenbaum, CJ; Havel, PJ; Klaff, LJ; Taborsky, GJ, 1991)
" We have used this model system to investigate whether 5 to 9 weeks of alloxan-induced hyperglycemia increases platelet adhesion and aggregation on a damaged vessel wall in vivo as well as platelet aggregation in vitro."	3.67	Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo. ( Ingerman-Wojenski, CM; Silver, MJ; Smith, M, 1987)
"25 female sheep of the Texel breed were made hyperglycaemic by administration of alloxan monohydrate (ALX) in early pregnancy and 15 ewes served as controls."	3.67	Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization. ( Eskes, TK; Jongsma, HW; Lips, JP, 1988)
"ICRF-187, (+)-1,2-bis(3,5-dioxopiperazine-1-yl)propane, has been shown to protect against alloxan diabetes (el-Hage et al."	3.67	Mechanism of the protective activity of ICRF-187 against alloxan-induced diabetes in mice. ( Crouch, RK; el-Hage, A; Ferrans, VJ; Herman, EH; Yang, GC, 1986)
"The ability of NiCl2 to prevent alloxan- and streptozotocin-induced hyperglycemia was tested in rats."	3.67	Nickel chloride protection against alloxan- and streptozotocin-induced diabetes. ( Novelli, EL; Ribas, BO; Rodrigues, NL, 1988)
"Hyperglycemia was induced in BALB/c mice with either streptozocin or alloxan to evaluate the effects of these drugs on primary lymphoidal tissues."	3.67	Definition of streptozocin toxicity for primary lymphoidal tissues. ( Wellhausen, SR, 1986)
"The effects of peripheral venous and portal venous delivery of insulin by a closed-loop insulin infusion device (Biostator GCIIS) on postprandial hyperglycemia and rates of glucose appearance, disappearance, and clearance were compared in alloxan-diabetic dogs."	3.66	Effect of peripheral versus portal venous administration of insulin on postprandial hyperglycemia and glucose turnover in alloxan-diabetic dogs. ( Clemens, AH; Gerich, JE; Hall, LD; Haymond, MW; Patton, GS; Rizza, RA; Service, FJ; Westland, RE, 1981)
"In two studies for toxicity, cataracts occurred in beagle dogs given diazoxide daily in high doses."	3.65	Cataracts in beagle dogs given diazoxide. ( Field, WE; Schiavo, DM; Vymetal, FJ, 1975)
"Alloxan diabetic mice were treated with EGCG."	1.72	(-)-Epigallocatechin gallate (EGCG) pharmacokinetics and molecular interactions towards amelioration of hyperglycemia, hyperlipidemia associated hepatorenal oxidative injury in alloxan induced diabetic mice. ( Adnan, M; Badraoui, R; Ben-Nasr, H; Chappard, D; El-Feki, A; Gargouri, M; Kausar, MA; Magné, C; Saeed, M; Siddiqui, AJ; Snoussi, M; Soussi, A, 2022)
"Anxiety, fear, and anhedonia are mediated by interactions between different deep structures of the temporal lobe (e."	1.43	Widespread blunting of hypothalamic and amygdala-septal activity and behavior in rats with long-term hyperglycemia. ( Contreras, CM; Guillén-Ruiz, G; Gutiérrez-García, AG; Moreno-Cortés, ML; Romo-González, T, 2016)
"Diosmin treatment produces significant reduction in the blood glucose and plasma insulin level and increases the body weight when compared with diabetic rats."	1.43	Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy. ( Ahmed, A; Ahmed, S; Bolshette, N; Borgohain, M; Chowdhury, L; Kwatra, M; Lahkar, M; Mundhe, N, 2016)
"In conclusion, chronic liraglutide treatment improves hyperglycemia by ameliorating beta cell mass and function in alloxan-induced diabetic mice."	1.42	Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. ( Iemoto, K; Kudo, M; Minami, K; Seino, S; Takahashi, H; Tamura, K, 2015)
"Hyperglycemia is the primary cause of the majority of diabetes complications, including diabetic retinopathy (DR)."	1.40	Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. ( Gurel, Z; Pratt, MR; Sheibani, N; Zaro, BW, 2014)
"Alloxan was then intraperitoneally administered, and blood glucose, glucose tolerance and the insulin level in mouse blood were examined."	1.39	Effect of vitamin E on alloxan-induced mouse diabetes. ( Doi, W; Ishihara, K; Kamimura, W; Masuoka, N; Oda, S; Sugiyama, H; Takemoto, K; Wang, DH, 2013)
"Hyperglycemia is independently related with excessive morbidity and mortality in cardiovascular disorders."	1.38	L-Arginine ameliorates cardiac left ventricular oxidative stress by upregulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats. ( Kumar, PH; Murugan, PS; Puhari, SS; Ramprasath, T; Selvam, GS; Vasudevan, V, 2012)
"Alloxan-treated dogs (D; n=7) were maintained normoglycemic using 24-h/d IV insulin replacement."	1.38	Chronic intrarenal insulin replacement reverses diabetes mellitus-induced natriuresis and diuresis. ( Brands, MW; Duggan, AD; Manhiani, MM; Wilson, H, 2012)
"Alloxan is a compound widely used in models of diabetes mellitus due to its ability for damage insulin-producing β-cells."	1.37	Inhibition of δ-aminolevulinate dehydratase is not closely related to the development of hyperglycemia in alloxan-induced diabetic mice. ( Barbosa, NB; Brito, VB; da Luz, SC; da Rocha, JB; de Carvalho, NR; Folmer, V; Puntel, GO, 2011)
"Treatment with telmisartan may prevent the onset of alloxan-induced diabetes even under acatalasemic conditions."	1.36	Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice. ( Fukuoka, N; Inoue, T; Kikumoto, Y; Kitagawa, M; Maeshima, Y; Makino, H; Masuoka, N; Morinaga, H; Ogino, K; Saeki, M; Sugiyama, H; Takiue, K; Wang, DH, 2010)
" comatus is less toxic to mice than vanadium (V)."	1.35	Comparison of hypoglycemic activity and toxicity of vanadium (IV) and vanadium (V) absorbed in fermented mushroom of Coprinus comatus. ( Fu, Q; Ma, Z, 2009)
" Pharmacokinetic and pharmacodynamic parameters were examined in the interval of 30 to 180 min after p."	1.34	Gliclazide: pharmacokinetic-pharmacodynamic relationships in rats. ( Kvetina, J; Pastera, J; Polásková, A; Prazáková, M; Stetinová, V, 2007)
"Pioglitazone treatment for 8 weeks affected GSH-Px activity in diabetic liver (261."	1.33	Effects of pioglitazone on hyperglycemia-induced alterations in antioxidative system in tissues of alloxan-treated diabetic animals. ( Gumieniczek, A, 2005)
"Stress hyperglycemia is frequent in critically ill patients."	1.32	Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. ( Coopmans, W; Giulietti, AP; Mathieu, C; Michalaki, M; Van den Berghe, G; Van Herck, E; Weekers, F, 2003)
" The aqueous extract of Syzygium alternifolium at a dosage of 0."	1.31	Hypoglycemic and antihyperglycemic activity of Syzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats. ( Rao, BK; Rao, CH, 2001)
"Alloxan is a diabetogenic agent which apparently acts through formation of superoxide radicals formed by redox cycling."	1.30	Enhanced alloxan-induced beta-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase. ( Jonsson, LM; Marklund, SL; Sentman, ML, 1999)
"Alloxan treatment, however, does not alter lymph insulin kinetics, indicating that insulin resistance of Type 1 (insulin-dependent) diabetes mellitus reflects direct impairment at the cellular level."	1.30	Evidence for direct action of alloxan to induce insulin resistance at the cellular level. ( Ader, M; Bergman, RN; Richey, JM, 1998)
" Our study was designed to explore dosage schedules which might improve rabbit responsiveness to and survival after alloxan treatment."	1.27	Variations of susceptibility to alloxan induced diabetes in the rabbit. ( Beyer, MM; Brown, CD; Friedman, EA; Watschinger, B; Zhao, ZH, 1987)

Timeframe	Studies, this research(%)	All Research%
pre-1990	58 (30.85)	18.7374
1990's	20 (10.64)	18.2507
2000's	32 (17.02)	29.6817
2010's	66 (35.11)	24.3611
2020's	12 (6.38)	2.80

Trial	Enrollment	Study Type	Start Date	Status
Impact of Bariatric Surgery on Circulating Inflammatory and Pro-vascular Progenitor Cell Populations.[NCT04132531]	38 participants (Actual)	Observational	2018-05-01	Completed
Determining the Factors That Affects Emergency Department Visits of Hyperglycemic Patients in 30 Days.[NCT04665128]	120 participants (Anticipated)	Observational	2020-12-15	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Attenuation of hyperglycemia and amadori products by aminoguanidine in alloxan-diabetic rabbits occurs via enhancement in antioxidant defenses and control of stress. PloS one, 2022, Volume: 17, Issue:1 Topics: Alloxan; Animals; Antioxidants; Case-Control Studies; Catalase; Diabetes Mellitus, Experimental; Dia	2022
The effects of taxifolin on neuropathy related with hyperglycemia and neuropathic pain in rats: A biochemical and histopathological evaluation. Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2022, Volume: 31, Issue:4 Topics: Alloxan; Animals; Antioxidants; Hyperglycemia; Male; Neuralgia; Oxidative Stress; Quercetin; Rats; R	2022
Acacia jacquemontii ethyl acetate extract reduces hyperglycemia and pro-inflammatory markers while increasing endogenous antioxidant potential in alloxan-induced diabetic rats. Environmental science and pollution research international, 2022, Volume: 29, Issue:35 Topics: Acacia; Alloxan; alpha-Amylases; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus,	2022
Detailed approach toward the anti-hyperglycemic potential of Sterculia diversifolia G. Don against alloxan-induced in vivo hyperglycemia model. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2022, Volume: 42, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Humans; Hyperglycemia; Hypoglycemi	2022
(-)-Epigallocatechin gallate (EGCG) pharmacokinetics and molecular interactions towards amelioration of hyperglycemia, hyperlipidemia associated hepatorenal oxidative injury in alloxan induced diabetic mice. Chemico-biological interactions, 2022, Dec-01, Volume: 368 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Catechin; Diabetes Mellitus, Experimental; Hyperglyce	2022
Co-administration of Current topics in medicinal chemistry, 2022, Volume: 22, Issue:32 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose	2022
Phytochemical profile and antioxidant capacity, α-amylase and α-glucosidase inhibitory activities of Oxalis pes-caprae extracts in alloxan-induced diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 160 Topics: Alloxan; alpha-Amylases; alpha-Glucosidases; Animals; Antioxidants; Diabetes Mellitus, Experimental;	2023
Therapeutic Potential of Frontiers in bioscience (Landmark edition), 2023, 05-26, Volume: 28, Issue:5 Topics: Alloxan; Animals; Antioxidants; Apoptosis; Diabetes Mellitus, Experimental; Dilleniaceae; Glucose Tr	2023
Phenolics Extracted from Molecules (Basel, Switzerland), 2023, Jul-17, Volume: 28, Issue:14 Topics: Alloxan; Animals; bcl-2-Associated X Protein; Biomarkers; Blood Glucose; Caspase 3; Diabetes Mellitu	2023
Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway. Oxidative medicine and cellular longevity, 2020, Volume: 2020 Topics: Alloxan; Animals; Caesalpinia; Diabetes Mellitus, Experimental; Disease Models, Animal; Herbal Medic	2020
Berberis lycium Royle. extracts attenuate inflammation and modulates hyperglycemia in alloxan induced diabetic rats. Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:4(Suppleme Topics: Alloxan; alpha-Amylases; Animals; Antioxidants; Berberis; Blood Glucose; Diabetes Mellitus, Experime	2020
Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse. Molecules (Basel, Switzerland), 2021, May-28, Volume: 26, Issue:11 Topics: Alloxan; Animals; Antioxidants; Apoptosis; Atherosclerosis; Blood Glucose; Caffeic Acids; Diabetes C	2021
Histopathological and biochemical assessments of Costus afer stem on alloxan-induced diabetic rats. Journal of basic and clinical physiology and pharmacology, 2017, Jul-26, Volume: 28, Issue:4 Topics: Alloxan; Animals; Biomarkers; Body Weight; Costus; Diabetes Mellitus, Experimental; Glyburide; Hyper	2017
Insight into anti-diabetic effect of low dose of stevioside. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 90 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diterpe	2017
Antihyperglycemic, antioxidant activities of tucumã oil (Astrocaryum vulgare) in alloxan-induced diabetic mice, and identification of fatty acid profile by gas chromatograph: New natural source to treat hyperglycemia. Chemico-biological interactions, 2017, May-25, Volume: 270 Topics: Alloxan; Animals; Antioxidants; Body Weight; Chromatography, Gas; Diabetes Mellitus, Experimental; E	2017
Brazilian TheScientificWorldJournal, 2017, Volume: 2017 Topics: Alloxan; Animals; Blood Glucose; Brazil; Diabetes Mellitus, Experimental; Dyslipidemias; Glucose Tol	2017
Amelioration of hyperglycaemia and modulation of antioxidant status by Alcea rosea seeds in alloxan-induced diabetic rats. Pharmaceutical biology, 2017, Volume: 55, Issue:1 Topics: Alloxan; Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; Dose-Response Relations	2017
Anti-hyperglycemic potential of Lactobacillus spp. in alloxan-induced Wistar rats. Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:2(Suppl.) Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Hyperglycemia; Hypogl	2017
The hypoglycemic and antioxidant effects of polysaccharides from the petioles and pedicels of Euryale ferox Salisb. on alloxan-induced hyperglycemic mice. Food & function, 2017, Oct-18, Volume: 8, Issue:10 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Female; Humans; Hype	2017
Report - Antidiabetic effects of native date fruit Aseel (Phoenix dactylifera L.) in normal and hyperglycemic rats. Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:5 Topics: Alloxan; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Fruit; Glyburide; Hype	2017
Anti-hyperglycaemic Effects of Rutin on Blood Glucose, Oxidative Stress Biomarkers and Lipid Peroxidation in Alloxan-induced Hyperglycaemic Wistar Rats. Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2017, Jun-30, Volume: 32, Issue:1 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hyperglycemia; Hypog	2017
The hypoglycemic and antioxidant activities of garden cress (Lepidium sativum L.) seed on alloxan-induced diabetic male rats. Natural product research, 2019, Volume: 33, Issue:6 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hyperglycemia; Hypog	2019
Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes. Cell stem cell, 2018, 01-04, Volume: 22, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Cellular Reprogramming; Dependovirus; Diabetes Mellitus, Experiment	2018
Effect of Moringa oleifera consumption on diabetic rats. BMC complementary and alternative medicine, 2018, Apr-10, Volume: 18, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enterobacteriaceae; F	2018
Therapeutic effect of vitamin B Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 105 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, T	2018
Antidiabetic Potentials of Citrus aurantifolia Leaf Essential Oil. Drug research, 2019, Volume: 69, Issue:4 Topics: Alloxan; Animals; Citrus; Gas Chromatography-Mass Spectrometry; Glucose; Glycogen; Hyperglycemia; Hy	2019
Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes. Investigative ophthalmology & visual science, 2018, 12-03, Volume: 59, Issue:15 Topics: Alloxan; Animals; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuro	2018
Antidiabetic role of a novel protein from garlic via NO in expression of Glut-4/insulin in liver of alloxan induced diabetic mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 111 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Garlic; Glucose; Glucose Transport	2019
Chemical constituents of Cochlospermum regium (Schrank) Pilg. root and its antioxidant, antidiabetic, antiglycation, and anticholinesterase effects in Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 111 Topics: Alloxan; Animals; Antioxidants; Bixaceae; Blood Glucose; Cholinesterase Inhibitors; Diabetes Mellitu	2019
Responsivity of lateral septum-mPFC connections in alloxan-induced hyperglycemia. Behavioural brain research, 2019, 08-05, Volume: 368 Topics: Alloxan; Animals; Antidepressive Agents; Brain; Diabetes Mellitus, Experimental; Fear; Fluoxetine; H	2019
Effect of vitamin E on alloxan-induced mouse diabetes. Clinical biochemistry, 2013, Volume: 46, Issue:9 Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Alloxan; alpha-Tocopherol; Animals; Antioxidants;	2013
Dynamics of lipid peroxidation-antioxidant defense system during alloxan diabetes in rats. Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:1 Topics: Alloxan; alpha-Tocopherol; Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Exp	2013
Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. Bulletin of experimental biology and medicine, 2013, Volume: 155, Issue:1 Topics: Alloxan; Animals; Astrocytes; Cerebral Cortex; Diabetes Mellitus, Experimental; Diencephalon; Female	2013
[Dynamics of initial manifestations of experimental diabetic encephalopathy]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 2013, Volume: 99, Issue:4 Topics: Alloxan; Animals; Behavior, Animal; Brain Diseases, Metabolic; Brain Mapping; Diabetes Mellitus, Exp	2013
Lavender (Lavandula stoechas L.) essential oils attenuate hyperglycemia and protect against oxidative stress in alloxan-induced diabetic rats. Lipids in health and disease, 2013, Dec-28, Volume: 12 Topics: Alloxan; Animals; Antioxidants; Biphenyl Compounds; Diabetes Mellitus, Experimental; Gas Chromatogra	2013
The protective effect of vanadium against diabetic cataracts in diabetic rat model. Biological trace element research, 2014, Volume: 158, Issue:2 Topics: Alloxan; Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypergl	2014
Therapeutic effects of stem cell on hyperglycemia, hyperlipidemia, and oxidative stress in alloxan-treated rats. Molecular and cellular biochemistry, 2014, Volume: 391, Issue:1-2 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Flow Cytometry; Glutathion	2014
[Protective effect of 3-oxypyridine and succinic acid derivatives under conditions of acute alloxan-induced intoxication in mice]. Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:1 Topics: Alloxan; Animals; Behavior, Animal; Female; Hyperglycemia; Male; Mice; Pyridines; Succinates	2014
Subacute antidiabetic and in vivo antioxidant effects of methanolic extract of Bridelia micrantha (Hochst Baill) leaf on alloxan-induced hyperglycaemic rats. Journal of complementary & integrative medicine, 2014, Volume: 11, Issue:2 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Dose-Respo	2014
Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. PloS one, 2014, Volume: 9, Issue:5 Topics: Acetylglucosamine; Alloxan; Animals; Apoptosis; Diabetic Retinopathy; Disease Models, Animal; Endoth	2014
Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. Life sciences, 2014, Jul-25, Volume: 109, Issue:1 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; DNA Damage; Glucose Transp	2014
Continuous electrical current and zinc sulphate administered by transdermal iontophoresis improves skin healing in diabetic rats induced by alloxan: morphological and ultrastructural analysis. Journal of diabetes research, 2014, Volume: 2014 Topics: Administration, Cutaneous; Alloxan; Animals; Cell Proliferation; Collagen; Diabetes Mellitus, Experi	2014
Study of Antiglycation, Hypoglycemic, and Nephroprotective Activities of the Green Dwarf Variety Coconut Water (Cocos nucifera L.) in Alloxan-Induced Diabetic Rats. Journal of medicinal food, 2015, Volume: 18, Issue:7 Topics: Acarbose; Alloxan; Animals; Antioxidants; Beverages; Caffeic Acids; Cocos; Diabetes Mellitus, Experi	2015
[Role of functional state of neuronal mitochondria of cerebral cortex in mechanisms of nootropic activity of neuroprotectors in rats with alloxan hyperglycemia]. Eksperimental'naia i klinicheskaia farmakologiia, 2015, Volume: 78, Issue:2 Topics: Alloxan; Amnesia; Animals; Avoidance Learning; Cerebral Cortex; Cognition; Cytidine Diphosphate Chol	2015
Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice. PloS one, 2015, Volume: 10, Issue:5 Topics: Alloxan; Animals; Apoptosis; Blood Glucose; Cell Proliferation; Cell Size; Diabetes Mellitus, Experi	2015
Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice. Nutrition research (New York, N.Y.), 2015, Volume: 35, Issue:5 Topics: Alloxan; Animals; Animals, Outbred Strains; Blood Glucose; Cordyceps; Deoxyadenosines; Diabetes Comp	2015
Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes. Mediators of inflammation, 2015, Volume: 2015 Topics: Alloxan; Animals; Bone Marrow; Cell Adhesion; Diabetes Mellitus; Humans; Hydrogen Peroxide; Hypergly	2015
Protective effect of vitamin E against alloxan-induced mouse hyperglycemia. Biochimica et biophysica acta, 2016, Volume: 1862, Issue:4 Topics: Acatalasia; Alloxan; Animals; Apoptosis; Hyperglycemia; Insulin; Male; Mice; Pancreas; Vitamin E	2016
Nanopharmaceutical approach using pelargonidin towards enhancement of efficacy for prevention of alloxan-induced DNA damage in L6 cells via activation of PARP and p53. Environmental toxicology and pharmacology, 2016, Volume: 43 Topics: Alloxan; Animals; Anthocyanins; Cell Line; DNA Damage; Hyperglycemia; Nanoparticles; Oxidative Stres	2016
Widespread blunting of hypothalamic and amygdala-septal activity and behavior in rats with long-term hyperglycemia. Behavioural brain research, 2016, 09-01, Volume: 310 Topics: Alloxan; Amygdala; Anhedonia; Animals; Anxiety; Chronic Disease; Dietary Sucrose; Disease Models, An	2016
A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia. Diabetologia, 2016, Volume: 59, Issue:9 Topics: Alloxan; Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Glucose; Ciliary Neurotrophic	2016
Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy. Inflammation, 2016, Volume: 39, Issue:5 Topics: Alloxan; Animals; Cytokines; Diabetic Nephropathies; Diosmin; Down-Regulation; Hyperglycemia; Hypogl	2016
Effects of hyperglycemia on bone metabolism and bone matrix in goldfish scales. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2017, Volume: 203 Topics: Alloxan; Animals; Blood Glucose; Bone and Bones; Electrophoresis, Polyacrylamide Gel; Goldfish; Hype	2017
The effect of a plant extract enriched in stigmasterol and β-sitosterol on glycaemic status and glucose metabolism in alloxan-induced diabetic rats. Food & function, 2016, Sep-14, Volume: 7, Issue:9 Topics: Alloxan; Animals; Biomarkers; Cell Line, Tumor; Diabetes Mellitus, Experimental; Dietary Supplements	2016
Hyperglycemia, oxidative stress, liver damage and dysfunction in alloxan-induced diabetic rat are prevented by Spirulina supplementation. Nutrition research (New York, N.Y.), 2016, Volume: 36, Issue:11 Topics: Alloxan; Animals; Anthocyanins; Blood Glucose; Catalase; Cholesterol; Diabetes Mellitus, Experimenta	2016
Effects of Cymodocea nodosa extract on metabolic disorders and oxidative stress in alloxan-diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 89 Topics: Alloxan; alpha-Amylases; Animals; Antioxidants; Blood Glucose; Cholesterol; Diabetes Mellitus, Exper	2017
O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Experimental cell research, 2008, Jul-01, Volume: 314, Issue:11-12 Topics: Acetylglucosamine; Alloxan; Animals; Apoptosis; Cell Line; Glucosamine; Glucose; Humans; Hyperglycem	2008
A comparison of hypoglycemic activity of three species of basidiomycetes rich in vanadium. Biological trace element research, 2009, Volume: 127, Issue:2 Topics: Alloxan; Analysis of Variance; Animals; Basidiomycota; Blood Glucose; Body Weight; Coprinus; Epineph	2009
Ocular refractive changes accompanying high blood sugar in alloxan-treated dogs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1948, Volume: 68, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Diagnostic Techniques, Ophthalmological; Dogs; Eye; Hyperglycemia;	1948
Kidney alkaline phosphatase of rats following alloxan induced diabetes and acute hypo- and hyperglycemia. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1948, Volume: 67, Issue:3 Topics: Alkaline Phosphatase; Alloxan; Animals; Diabetes Mellitus, Experimental; Hyperglycemia; Rats	1948
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake. Chemico-biological interactions, 2009, May-15, Volume: 179, Issue:2-3 Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchic	2009
Comparison of hypoglycemic activity and toxicity of vanadium (IV) and vanadium (V) absorbed in fermented mushroom of Coprinus comatus. Biological trace element research, 2009, Volume: 132, Issue:1-3 Topics: Alloxan; Animals; Blood Glucose; Coprinus; Hyperglycemia; Mice; Mice, Obese; Sucrose; Vanadium	2009
Expression and characterization of Momordica Chanrantia anti-hyperglycaemic peptide in Escherichia coli. Molecular biology reports, 2010, Volume: 37, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experiment	2010
STUDIES ON GLYCOGEN NEPHROSIS IN ALLOXAN-TREATED DIABETIC RATS. The Journal of experimental medicine, 1947, Mar-31, Volume: 85, Issue:4 Topics: Alloxan; Animals; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glycogen; Hypergl	1947
Sensitization to alloxan-induced diabetes and pancreatic cell apoptosis in acatalasemic mice. Biochimica et biophysica acta, 2010, Volume: 1802, Issue:2 Topics: Acatalasia; Alloxan; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Benzimidazoles; Be	2010
The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats. The Journal of surgical research, 2011, Volume: 169, Issue:1 Topics: Alloxan; Animals; Antioxidants; Catalase; Cytokines; Diabetes Mellitus, Experimental; Disease Models	2011
Inhibition of δ-aminolevulinate dehydratase is not closely related to the development of hyperglycemia in alloxan-induced diabetic mice. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2011, Volume: 63, Issue:5 Topics: Alloxan; Animals; Blood Glucose; Enzyme Activation; Enzyme Inhibitors; Hyperglycemia; Kidney; Lipid	2011
In vivo acute effects of orally administered hydro-ethanol extract of Catha edulis on blood glucose levels in normal, glucose-fed hyperglycemic, and alloxan-induced diabetic rats. Saudi medical journal, 2010, Volume: 31, Issue:6 Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Catha; Diabetes Mellitus, Experimental; Gluco	2010
A method for consistent induction of chronic hyperglycemia with alloxan. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1945, Volume: 60 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Humans; Hyperglycemia	1945
Chemical characterization of various fractions of leaves of Cinnamomum tamala Linn toward their antioxidant, hypoglycemic, and anti-inflammatory property. Immunopharmacology and immunotoxicology, 2011, Volume: 33, Issue:3 Topics: Alloxan; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Cells, Cultured; Cinnamomum;	2011
Effects of two oral antidiabetics, pioglitazone and repaglinide, on aconitase inactivation, inflammation and oxidative/nitrosative stress in tissues under alloxan-induced hyperglycemia. European journal of pharmacology, 2011, May-20, Volume: 659, Issue:1 Topics: Aconitate Hydratase; Administration, Oral; Alloxan; Animals; Blood Glucose; Body Weight; Carbamates;	2011
Hypoglycaemic action of stevioside and а barley and brewer's yeast based preparation in the experimental model on mice. Bosnian journal of basic medical sciences, 2011, Volume: 11, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Chromium; Diabetes Mellitus, Experimental; Disease Models, Animal;	2011
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:7 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease	2011
The influence of alloxan-induced diabetes on Müller cell contraction-promoting activities in vitreous. Investigative ophthalmology & visual science, 2011, Sep-27, Volume: 52, Issue:10 Topics: Alloxan; Animals; Blood Glucose; Blotting, Western; Carbonic Anhydrase I; Carbonic Anhydrase II; Dia	2011
Oral administration of levan polysaccharide reduces the alloxan-induced oxidative stress in rats. International journal of biological macromolecules, 2011, Dec-01, Volume: 49, Issue:5 Topics: Administration, Oral; Alloxan; Animals; Bacillus; Blood Glucose; Catalase; Diabetes Mellitus, Experi	2011
Antihyperglycemic potentials of a threatened plant, Helonias dioica: antioxidative stress responses and the signaling cascade. Experimental biology and medicine (Maywood, N.J.), 2012, Volume: 237, Issue:1 Topics: Alloxan; Animals; Caspase 3; Catalase; Cells, Cultured; Cyclooxygenase 2; Cytochromes c; DNA Damage;	2012
Chronic intrarenal insulin replacement reverses diabetes mellitus-induced natriuresis and diuresis. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Disease Models, An	2012
Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Di	2012
The control of hyperglycemia in alloxan treated diabetic mice through the stimulation of hepatic insulin synthesis due to the production of nitric oxide. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2012, Volume: 120, Issue:3 Topics: Administration, Cutaneous; Administration, Oral; Alloxan; Animals; Anti-Inflammatory Agents, Non-Ste	2012
[Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:12 Topics: Alloxan; Animals; Conditioning, Classical; Diabetes Mellitus, Experimental; Diabetic Neuropathies; D	2011
Insulin growth factor adjustment in preimplantation rabbit blastocysts and uterine tissues in response to maternal type 1 diabetes. Molecular and cellular endocrinology, 2012, Jul-06, Volume: 358, Issue:1 Topics: Alloxan; Animals; Blastocyst; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes Mellit	2012
Effects of insulin-like growth factor I on alveolar bone remodeling in diabetic rats. Journal of periodontal research, 2013, Volume: 48, Issue:2 Topics: Alloxan; Alveolar Process; Animals; Blood Glucose; Bone Density; Bone Remodeling; Calcification, Phy	2013
Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2012, Volume: 12, Issue:7 Topics: Alloxan; Animals; Atrial Fibrillation; Atrial Remodeling; Diabetes Mellitus, Experimental; Disease M	2012
Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits. Experimental eye research, 2012, Volume: 103 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Cataract; Diabetes Mellitus, Experimental; Hyperglycem	2012
L-Arginine ameliorates cardiac left ventricular oxidative stress by upregulating eNOS and Nrf2 target genes in alloxan-induced hyperglycemic rats. Biochemical and biophysical research communications, 2012, Nov-23, Volume: 428, Issue:3 Topics: Alloxan; Animals; Arginine; Caspase 3; Diabetes Mellitus, Experimental; Gene Expression Regulation;	2012
Early pancreas transplant improves motor nerve conduction in alloxan-induced diabetic rats. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2012, Volume: 120, Issue:10 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Progression; Glyca	2012
In vitro and in vivo assessment of the antioxidant activity of melatonin and related indole derivatives. General physiology and biophysics, 2002, Volume: 21, Issue:2 Topics: Alloxan; Animals; Antioxidants; Carboxylic Acids; Female; Hyaluronic Acid; Hyperglycemia; In Vitro T	2002
Antihyperglycaemic effect and acute toxicity of Securigera Securidaca L. seed extracts in mice. Phytotherapy research : PTR, 2002, Volume: 16, Issue:8 Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Respons	2002
Hypoglycemic activity of ginseng glycopeptide. Acta pharmacologica Sinica, 2003, Volume: 24, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Glycogen; Glycopeptides; Hyperglycemia; Hypoglycemic Agents; Liver;	2003
Lipid hydroperoxide induced corneal neovascularization in hyperglycemic rabbits. Current eye research, 2002, Volume: 25, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Corneal Neovascularization; Endothelial Growth Factors; Glycated He	2002
[Experimental study on the hypoglycemic effect of tangniaole capsule]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2002, Volume: 25, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Capsules; Diabetes Mellitus, Experimental; Dioscorea; Drugs, Chines	2002
Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants. European journal of medicinal chemistry, 2003, Volume: 38, Issue:1 Topics: Alloxan; Animals; Antioxidants; Body Temperature; Drug Evaluation, Preclinical; Hyperglycemia; Lipid	2003
Antihyperglycemic activity of Caralluma attenuata. Fitoterapia, 2003, Volume: 74, Issue:3 Topics: Administration, Oral; Alloxan; Animals; Apocynaceae; Blood Glucose; Diabetes Mellitus, Experimental;	2003
In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage. Life sciences, 2003, Sep-19, Volume: 73, Issue:18 Topics: Alloxan; Animals; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; Dose-Response Rel	2003
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology, 2003, Volume: 144, Issue:12 Topics: Alloxan; Animals; Blood Gas Analysis; Blood Glucose; Body Weight; Burns; Critical Illness; Diabetes	2003
Hyperglycemia-glycogenolytic factor in diabetic man and alloxan-diabetic animals. The American journal of physiology, 1952, Volume: 171, Issue:2 Topics: Alloxan; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Glucagon; Humans; Hyperglycemi	1952
[Direct glycogenolytic effect of alloxan in the mechanism of initial hyperglycemia of alloxan poisoning]. Comptes rendus des seances de la Societe de biologie et de ses filiales, 1953, Volume: 147, Issue:3-4 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glycogenolysis; Hyperglycemia	1953
Studies on the mechanism of alloxan initial hyperglycemia. I. A role of pituitary and adrenal gland in connection with the effect of alloxan on the blood sugar. The Tohoku journal of experimental medicine, 1954, Apr-25, Volume: 59, Issue:4 Topics: Adrenal Glands; Alloxan; Blood Glucose; Hyperglycemia; Pituitary Gland	1954
Studies on the mechanism of alloxan initial hyperglycemia. II. Role of the liver in connection with the effect of alloxan on the blood sugar. The Tohoku journal of experimental medicine, 1954, Apr-25, Volume: 59, Issue:4 Topics: Abdomen; Alloxan; Blood Glucose; Hyperglycemia; Liver; Portal System	1954
Studies on the mechanism of primary alloxan hyperglycemia and hypoglycemia in rabbits. The Indian journal of medical research, 1955, Volume: 43, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Hyperglycemia; Hypoglycemia; Rabbits	1955
Effect of alloxan on obese hyperglycaemic mice. Nature, 1962, Jan-13, Volume: 193 Topics: Alloxan; Animals; Hyperglycemia; Mice; Mice, Obese; Obesity	1962
EXTREME SENSITIVITY OF OBESE HYPERGLYCEMIC MICE TO CAFFEINE AND COFFEE. Metabolism: clinical and experimental, 1964, Volume: 13 Topics: Alloxan; Animals; Blood Glucose; Caffeine; Coffee; Glucose Tolerance Test; Hyperglycemia; Insulin; M	1964
[Inhibiting effect of adrenalectomy on alloxan hyperglycemia]. Bulletin. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, 1954, Volume: 11, Issue:2 Topics: Adrenal Glands; Adrenalectomy; Alloxan; Animals; Diabetes Mellitus, Experimental; Hyperglycemia	1954
[Effect of adrenal grafts in the anterior chamber of the eye on alloxan hyperglycemia in rat]. Bulletin. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, 1954, Volume: 11, Issue:2 Topics: Adrenal Glands; Alloxan; Animals; Anterior Chamber; Diabetes Mellitus, Experimental; Hyperglycemia;	1954
[Studies on physiopathology of hypothermia in homotherms; effect of deep hypothermia on alloxan hyperglycemia]. Bulletin. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka, 1954, Volume: 11, Issue:2 Topics: Alloxan; Animals; Body Temperature; Diabetes Mellitus, Experimental; Hyperglycemia; Hypothermia	1954
The effect of amphenone and DDD on the early post-alloxanic hyperglycemia in rats. Folia endocrinologica; mensile di incretologia e incretoterapia, 1960, Volume: 13 Topics: Alloxan; Animals; Contraceptive Agents, Female; DDT; Dichlorodiphenyldichloroethane; Estradiol Conge	1960
Hypoglycemic effect of Rehmannia glutinosa oligosaccharide in hyperglycemic and alloxan-induced diabetic rats and its mechanism. Journal of ethnopharmacology, 2004, Volume: 90, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Corticosterone; Diabetes Mellitus, Experimental; Female; Glucose-6-	2004
[Mechanism of the transitory hyperglycemia determined by alloxan]. Bollettino della Societa italiana di biologia sperimentale, 1950, Volume: 26, Issue:7 Topics: Alloxan; Blood Glucose; Hyperglycemia	1950
Third ventricular alloxan reversibly impairs glucose counterregulatory responses. Diabetes, 2004, Volume: 53, Issue:5 Topics: Alloxan; Animals; Blood Glucose; Eating; Enzyme Inhibitors; Fourth Ventricle; Glucokinase; Glucose;	2004
Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. The Yale journal of biology and medicine, 2003, Volume: 76, Issue:3 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Eclipta; Hyperglycemia; Hypoglycemic Agents; Male	2003
Prevailing hyperglycemia is critical in the regulation of glucose metabolism during exercise in poorly controlled alloxan-diabetic dogs. Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 98, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Drug Combinations; Exercise	2005
Effects of pioglitazone on hyperglycemia-induced alterations in antioxidative system in tissues of alloxan-treated diabetic animals. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2005, Volume: 56, Issue:4-5 Topics: Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase	2005
Involvement of Ca2+/calmodulin-dependent protein kinase II in the modulation of indolamines in diabetic and hyperglycemic rats. Journal of neuroscience research, 2005, May-15, Volume: 80, Issue:4 Topics: Acidosis; Alloxan; Ammonium Chloride; Analysis of Variance; Animals; Bicarbonates; Blood Glucose; Bl	2005
Age-related differences in the degree of lipid peroxidation and state of antioxidant protection under the influence of alloxan. Bulletin of experimental biology and medicine, 2005, Volume: 139, Issue:3 Topics: Aging; Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Hyperglycemia; Hyperlipidemi	2005
Hypoglycemic effect of ethanolic extract of Musa sapientum on alloxan induced diabetes mellitus in rats and its relation with antioxidant potential. Journal of herbal pharmacotherapy, 2005, Volume: 5, Issue:2 Topics: Administration, Oral; Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental	2005
Hypoglycemic and antiperglycemic effects of Semecarpus anacardium linn in normal and alloxan-induced diabetic rats. Journal of herbal pharmacotherapy, 2005, Volume: 5, Issue:2 Topics: Administration, Oral; Alloxan; Analysis of Variance; Animals; Antioxidants; Blood Glucose; Diabetes	2005
Hypoglycemic activity of fermented mushroom of Coprinus comatus rich in vanadium. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 2006, Volume: 20, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Coprinus; Epinephrine; Female; Fermentation; Glucose Tolerance Test	2006
Gliclazide: pharmacokinetic-pharmacodynamic relationships in rats. Biopharmaceutics & drug disposition, 2007, Volume: 28, Issue:5 Topics: Administration, Oral; Alloxan; Animals; Area Under Curve; Blood Glucose; Chromatography, High Pressu	2007
Effect of hyperglycemia on the efficacy of morphine analgesia in rats. African journal of medicine and medical sciences, 2006, Volume: 35, Issue:4 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Female; Hyperglycemia; Morphine; Pain; Pain Measu	2006
Hyperglycemia and glucosuria following thyroid administration in alloxan treated rats. The Journal of laboratory and clinical medicine, 1949, Volume: 34, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Carbohydrates; Glycosuria; Hyperglycemia; Rats; Thyroid Gland; Urin	1949
The effect of altered carbohydrate metabolism in pertussis-sensitized mice on anaphylaxis. Biochemical pharmacology, 1967, Volume: 16, Issue:5 Topics: Alloxan; Anaphylaxis; Animals; Blood Glucose; Body Weight; Diazoxide; Eating; Epinephrine; Female; G	1967
On the hyperglycaemic effect of DOPA and dopamine. European journal of pharmacology, 1967, Volume: 1, Issue:2 Topics: Alloxan; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Dihydroxyphenylalanine; Dopamine; Hy	1967
Complications of pregnancy and fetal development. Diabetes, 1982, Volume: 31, Issue:Suppl 1 Pt Topics: Alloxan; Animals; Congenital Abnormalities; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental;	1982
Survival of intrasplenically implanted islets in mice with experimental insulitis and hyperglycemia. Diabetes, 1982, Volume: 31 Suppl 4 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Graft Survival	1982
Alloxan-induced hyperglycemia increases progestin and androgen accumulation by isolated rabbit follicles in vitro. Experientia, 1984, Mar-15, Volume: 40, Issue:3 Topics: Alloxan; Androgens; Animals; Female; Hyperglycemia; Luteinizing Hormone; Ovarian Follicle; Progestin	1984
Effects of acetazolamide on insulin release, serum glucose and insulin, glucose tolerance, and alloxan sensitivity of mice. Medical biology, 1980, Volume: 58, Issue:3 Topics: Acetazolamide; Alloxan; Animals; Blood Glucose; Carbonic Anhydrases; Glucose Tolerance Test; Hypergl	1980
Effect of peripheral versus portal venous administration of insulin on postprandial hyperglycemia and glucose turnover in alloxan-diabetic dogs. Mayo Clinic proceedings, 1981, Volume: 56, Issue:7 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Eating; Hyperglycemia; Injec	1981
Importance of glucagon in mediating epinephrine-induced hyperglycemia in alloxan-diabetic dogs. The American journal of physiology, 1981, Volume: 241, Issue:4 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Dogs; Epinephrine; Glucagon; Glucose; Hyperglycem	1981
Comparison of systemic and uterine effects of relaxin and insulin in alloxan-treated, hyperglycemic rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1982, Volume: 169, Issue:3 Topics: Alloxan; Animals; Castration; Diabetes Mellitus, Experimental; Estradiol; Female; Hyperglycemia; Ins	1982
Effect of 'catalin' an anticataract agent on alloxan induced hyperglycaemia and diabetic cataract in rats. Indian journal of ophthalmology, 1980, Volume: 28, Issue:1 Topics: Alloxan; Animals; Cataract; Diabetes Mellitus, Experimental; Female; Hyperglycemia; Male; Oxazines;	1980
Effect of hyperglycemia on the enzyme activities of lenticular tissue of rats. Experimental eye research, 1980, Volume: 31, Issue:4 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Hyperglycemia; Lens, Crystalline; Rats	1980
Long-term effects of alloxan in mice. International journal of pancreatology : official journal of the International Association of Pancreatology, 1995, Volume: 17, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Carbachol; Diabetes Mellitus, Experimental; Dose-Response Relations	1995
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice. The Journal of clinical investigation, 1995, Volume: 96, Issue:2 Topics: Adolescent; Adult; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glu	1995
Comparison of retinal lesions in alloxan-diabetic rats and galactose-fed rats. Current eye research, 1994, Volume: 13, Issue:12 Topics: Alloxan; Animals; Basement Membrane; Capillaries; Diabetes Mellitus, Experimental; Diabetic Retinopa	1994
Pancreatic lipid peroxidation in alloxan-induced diabetes mellitus. Archives of medical research, 1994,Winter, Volume: 25, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Hyperglycemia; Lipid	1994
A new diabetes model induced by neonatal alloxan treatment in rats. Diabetes research and clinical practice, 1993, Volume: 20, Issue:3 Topics: Acetylglucosaminidase; Aging; Alloxan; Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabet	1993
Control of hyperglycaemia in diabetic rabbits by a combination of implants. Journal of biomedical engineering, 1993, Volume: 15, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Implants; Eating; Hyperglycem	1993
Plasma atrial natriuretic peptide levels in rabbits with alloxan monohydrate-induced diabetes mellitus. Japanese heart journal, 1995, Volume: 36, Issue:6 Topics: Alloxan; Animals; Atrial Natriuretic Factor; Blood Glucose; Diabetes Mellitus, Experimental; Electro	1995
Inhibition of alloxan-induced hyperglycaemia in mice by the pyridoindole stobadine. Pharmacology & toxicology, 1995, Volume: 77, Issue:5 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Carbolines; Disease Models, Animal; Dose-Response Rel	1995
Oxygen consumption and ATPase activity in the corneal epithelium of rabbits with alloxan induced hyperglycemia. Acta ophthalmologica Scandinavica, 1998, Volume: 76, Issue:5 Topics: Adenosine Triphosphatases; Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experime	1998
Evidence for direct action of alloxan to induce insulin resistance at the cellular level. Diabetologia, 1998, Volume: 41, Issue:11 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dogs; Glucose Clamp Technique; Glu	1998
Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia. British journal of pharmacology, 1999, Volume: 126, Issue:1 Topics: Alloxan; Animals; Arginine; Blood Glucose; Body Weight; Carotid Arteries; Cyclic GMP; Endothelium, V	1999
Effect of some antidepressants on glycaemia and insulin levels of normoglycaemic and alloxan-induced hyperglycaemic mice. The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:6 Topics: Alloxan; Animals; Antidepressive Agents; Blood Glucose; Female; Fluoxetine; Hyperglycemia; Insulin;	1999
Enhanced alloxan-induced beta-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase. Free radical biology & medicine, 1999, Volume: 27, Issue:7-8 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Free Radicals; Hyperglycem	1999
Reduced nociceptive responses in mice with alloxan induced hyperglycemia after garlic (Allium sativum Linn.) treatment. Indian journal of experimental biology, 1999, Volume: 37, Issue:7 Topics: Alloxan; Animals; Garlic; Hyperglycemia; Male; Mice; Pain; Plant Extracts; Plants, Medicinal	1999
Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFkappaB activation offering protection against chemically induced diabetes. Free radical biology & medicine, 2000, Feb-15, Volume: 28, Issue:4 Topics: Alloxan; Animals; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free	2000
Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2-dihydroquinoline (S 33113) in models of cerebral neurodegeneration. European journal of pharmacology, 2001, Mar-23, Volume: 416, Issue:1-2 Topics: Alloxan; Animals; Antioxidants; Body Temperature; Brain Ischemia; Cell Survival; Cerebral Cortex; Co	2001
Hypoglycemic and antihyperglycemic activity of Syzygium alternifolium (Wt.) Walp. seed extracts in normal and diabetic rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2001, Volume: 8, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug;	2001
Urethane-induced hyperglycemia. Acta pharmacologica Sinica, 2000, Volume: 21, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Epinephrine; Fasting; Hyperglycemia; Insulin; Male; Rats; Urethane	2000
Administration of NF-kappaB decoy inhibits pancreatic activation of NF-kappaB and prevents diabetogenesis by alloxan in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:9 Topics: Alloxan; Animals; Apoptosis; Diabetes Mellitus, Experimental; Disease Models, Animal; Hyperglycemia;	2001
Effect of aluminum on the blood-brain barrier permeability in acute and chronically hyperglycemic rats. Biological trace element research, 2001, Volume: 80, Issue:2 Topics: Acute Disease; Alloxan; Aluminum; Animals; Blood-Brain Barrier; Chronic Disease; Coloring Agents; Ev	2001
The protective effect of Amomum xanthoides extract against alloxan-induced diabetes through the suppression of NFkappaB activation. Experimental & molecular medicine, 2001, Jun-30, Volume: 33, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Cell Nucleus; Diabetes Mellitus, Experimental; Dose-Response Relati	2001
[Experimental grafts of pancreatic islands of Langerhans in the rat]. Chirurgia e patologia sperimentale, 1978, Volume: 26, Issue:4 Topics: Alloxan; Animals; Body Weight; Glycosuria; Hyperglycemia; Islets of Langerhans; Islets of Langerhans	1978
Increased sensitivity of in vivo platelet aggregation in rabbits after alloxan or streptozotocin. British journal of experimental pathology, 1976, Volume: 57, Issue:1 Topics: Adenosine Diphosphate; Alloxan; Animals; Blood Glucose; Cerebral Cortex; Diabetes Mellitus, Experime	1976
Antagonism of cadmium and alloxan-induced hyperglycemia in rats by Trigonella foenum graecum. Pahlavi medical journal, 1977, Volume: 8, Issue:1 Topics: Acetone; Alloxan; Animals; Cadmium; Diabetes Mellitus, Experimental; Hyperglycemia; Hypoglycemic Age	1977
Distribtuion of gamma-aminobutyric acid (GABA) in the rat hypothalamus: functional correlates of GABA wtih activities of appetite controlling mechanisms. Journal of neurochemistry, 1975, Volume: 24, Issue:5 Topics: Alloxan; Aminobutyrates; Animals; Appetite; gamma-Aminobutyric Acid; Hyperglycemia; Hypothalamus; Hy	1975
Cataracts in beagle dogs given diazoxide. Diabetes, 1975, Volume: 24, Issue:12 Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Cataract; Diazoxide; Dogs; Dose-Response Rela	1975
Inhibition of alloxan-induced hyperglycaemia by compounds of similar molecular structure. Biochemical pharmacology, 1992, Dec-01, Volume: 44, Issue:11 Topics: Allantoin; Alloxan; Animals; Barbiturates; Blood Glucose; Caffeine; Ethosuximide; Hyperglycemia; Ino	1992
Intra-islet insulin permits glucose to directly suppress pancreatic A cell function. The Journal of clinical investigation, 1991, Volume: 88, Issue:3 Topics: Alloxan; Animals; Arginine; Dogs; Glucagon; Glucose; Hyperglycemia; Insulin; Insulin Secretion; Isle	1991
Activated monocytes and granulocytes, capillary nonperfusion, and neovascularization in diabetic retinopathy. The American journal of pathology, 1991, Volume: 139, Issue:1 Topics: Alloxan; Animals; Capillaries; Diabetic Retinopathy; Granulocytes; Hyperglycemia; Leukocytes; Macrop	1991
Effect of intracerebroventricularly administered insulin on brain monoamines and acetylcholine in euglycaemic and alloxan-induced hyperglycaemic rats. Indian journal of experimental biology, 1991, Volume: 29, Issue:12 Topics: Acetylcholine; Alloxan; Animals; Biogenic Monoamines; Hyperglycemia; Injections, Intraventricular; I	1991
Increased incidence of neuroleptic-induced perioral movements in the rat by hyperglycemia. The International journal of neuroscience, 1990, Volume: 50, Issue:3-4 Topics: Alloxan; Animals; Blood Glucose; Dyskinesia, Drug-Induced; Female; Haloperidol; Hyperglycemia; Rats;	1990
Modulation of insulin receptors and catecholamines in rat brain in hyperglycemia and hyperinsulinemia. Biochemistry international, 1990, Volume: 22, Issue:1 Topics: Alloxan; Animals; Brain; Catecholamines; Cell Membrane; Choroid Plexus; Chromatography, High Pressur	1990
Definition of streptozocin toxicity for primary lymphoidal tissues. Diabetes, 1986, Volume: 35, Issue:12 Topics: Alloxan; Animals; Bone Marrow; Bone Marrow Cells; Cell Cycle; DNA; Hyperglycemia; Leukocyte Count; L	1986
Nickel chloride protection against alloxan- and streptozotocin-induced diabetes. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1988, Volume: 21, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Ceruloplasmin; Diabetes Mellitus, Experimental; Hyperglycemia; Insu	1988
Mechanism of the protective activity of ICRF-187 against alloxan-induced diabetes in mice. Research communications in chemical pathology and pharmacology, 1986, Volume: 52, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Chelating Agents; Cimetidine; Diabetes Mellitus, Experimental; Dime	1986
Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization. Laboratory animals, 1988, Volume: 22, Issue:1 Topics: Alloxan; Animals; Birth Weight; Blood Gas Analysis; Blood Glucose; Catheterization; Diabetes Mellitu	1988
Variations of susceptibility to alloxan induced diabetes in the rabbit. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:11 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Susceptibility; D	1987
Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo. Thrombosis research, 1987, Jun-01, Volume: 46, Issue:5 Topics: Adenosine Diphosphate; Alloxan; Animals; Arteries; Blood Platelets; Cell Adhesion; Collagen; Diabete	1987
The influence of estrogen on the hyperglycemic action of alloxan in female rats. Proceedings of the National Science Council, Republic of China. Part B, Life sciences, 1986, Volume: 10, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Estrogens; Estrus; Female; Glucose Tolerance Test; Hyperglycemia; O	1986
Changes in the rats preference for saccharin and sodium chloride solutions following injection of alloxan monohydrate. Journal of comparative and physiological psychology, 1974, Volume: 87, Issue:6 Topics: Age Factors; Alloxan; Animals; Appetite; Avoidance Learning; Blood Glucose; Body Weight; Chronic Dis	1974
[Proceedings: Hyperglycemia in the early phase of alloxan administration and sympathetic nerve interruption]. Nihon seirigaku zasshi. Journal of the Physiological Society of Japan, 1974, Sep-01, Volume: 36, Issue:8-9 Topics: Alloxan; Hyperglycemia; Sympathetic Nervous System	1974
Acute effects of alloxan on the metabolism and insulin secretion of the pancreatic B-cell. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1973, Volume: 5, Issue:6 Topics: Alloxan; Anaerobiosis; Animals; Carbon Radioisotopes; Citrates; Female; Genotype; Glucose; Glycolysi	1973
The relationship of hyperglycemia to periodontal disease. Journal of periodontology, 1973, Volume: 44, Issue:5 Topics: Alloxan; Animals; Haplorhini; Hyperglycemia; Macaca; Periodontal Diseases; Pituitary Hormones, Anter	1973
Studies on the protective effect of diphenylhydantoin against alloxan diabetes in mice. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:1 Topics: Alloxan; Animals; Binding, Competitive; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Hyp	1973
Sulfhydryl inhibitors and pancreatic islet tissue. Acta endocrinologica. Supplementum, 1969, Volume: 139 Topics: Alloxan; Animals; Arsenicals; Cadmium; Chlorides; Cobalt; Diabetes Mellitus, Experimental; Fishes; H	1969
Effects of alloxan upon goldfish (Carassius auratus L.). General and comparative endocrinology, 1970, Volume: 14, Issue:3 Topics: Adrenal Glands; Alloxan; Animals; Blood Glucose; Cyprinidae; Diabetes Mellitus, Experimental; Epinep	1970
Alloxan effects on blood glucose level and pancreatic islet tissue in Lampetra fluviatilis. General and comparative endocrinology, 1970, Volume: 15, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fishes; Hyperglycemia; Isl	1970
[Inhibition of diabetogenic effect of alloxan by intraperitoneal administration of glucose in mice]. Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles, 1970, Aug-10, Volume: 271, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Hyperglycemia; Injections	1970
Infectivity of Trichinella spiralis (nematoda) muscle larva in normal- vs. alloxan-treated rats. Experientia, 1972, Jan-15, Volume: 28, Issue:1 Topics: Alloxan; Animals; Diaphragm; Glycogen; Hyperglycemia; Larva; Male; Muscles; Rats; Trichinella; Trich	1972
Effect of ecdysterone on hyperglycemia in experimental animals. Biochemical pharmacology, 1971, Volume: 20, Issue:12 Topics: Alloxan; Animals; Carbon Isotopes; Cholestanes; Diabetes Mellitus, Experimental; Drug Antagonism; Gl	1971
The effect of agents used in the treatment of bronchial asthma on carbohydrate metabolism and histamine sensitivity after beta-adrenergic blockade. The Journal of allergy, 1970, Volume: 45, Issue:2 Topics: Adenine Nucleotides; Adrenal Cortex Hormones; Adrenalectomy; Alloxan; Aminophylline; Animals; Antige	1970
Ultrastructural pancreatic beta-cell changes in rabbits after small and large doses of alloxan. Diabetes, 1967, Volume: 16, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Cortisone; Diabetes Mellitus, Experimental; Hyperglycemia; In Vitro	1967
[Enzyme activity of 3 beta-ol-steroid dehydrogenase in the adrenal cortex: histochemical studies following alloxan treatment]. Endokrinologie, 1969, Volume: 54, Issue:1 Topics: Adrenal Glands; Alloxan; Animals; Diabetes Mellitus, Experimental; Guinea Pigs; Histocytochemistry;	1969
Partial reversal of the in vivo antimalarial activity of DDS against Plasmodium berghei by induced hyperglycemia. The American journal of tropical medicine and hygiene, 1971, Volume: 20, Issue:4 Topics: Administration, Oral; Alloxan; Animals; Antimalarials; Blood Glucose; Dapsone; Erythrocytes; Glucose	1971
Liver insulinase activity in insulin deficient rats. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 127, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Endopeptidases; Enzyme Induction; Fasting; Hyperglycem	1968
[Inhivition of inflammatory reactions by hyperglycemia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1968, Volume: 64, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Bradykinin; Dextrans; Glucose; Guinea Pigs; Hexoses; Histamine; Hyp	1968

alloxan and Hyperglycemia

Research Excerpts

Research

Studies (188)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Other Studies

Authors	Studies
Arif, B	1
Arif, Z	1
Ahmad, J	1
Perveen, K	1
Bukhari, NA	1
Ashraf, JM	1
Alam, K	1
Alay, M	1
Sonmez, MG	1
Sakin, A	1
Atmaca, M	1
Suleyman, H	2
Yazici, GN	1
Coban, A	1
Suleyman, B	1
Bulut, S	1
Altuner, D	1
Awan, AM	1
Majeed, W	3
Muhammad, F	1
Faisal, MN	1
Fazle, R	1
Amir, Z	1
Amna, N	2
Achyut, A	1
Irfan, U	1
Shafiq Ur, R	1
Soussi, A	1
Gargouri, M	2
Magné, C	2
Ben-Nasr, H	1
Kausar, MA	1
Siddiqui, AJ	1
Saeed, M	1
Snoussi, M	1
Adnan, M	1
El-Feki, A	1
Chappard, D	1
Badraoui, R	1
Sharma, N	1
Kar, A	1
Panda, S	1
Yadav, D	1
Kabach, I	1
Bouchmaa, N	1
Zouaoui, Z	1
Ennoury, A	1
El Asri, S	1
Laabar, A	1
Oumeslakht, L	1
Cacciola, F	1
El Majdoub, YO	1
Mondello, L	1
Zyad, A	1
Nhiri, N	1
Nhiri, M	1
Ben Mrid, R	1
Sahariah, P	1
Bora, J	1
Malik, S	1
Syiem, D	1
Bhan, S	1
Hussain, A	1
Sadier, NS	1
Rustagi, S	1
Haque, S	1
Singh, N	1
Almutary, AG	1
Umar, U	1
Ahmed, S	3
Iftikhar, A	2
Iftikhar, M	2
Liaqat, A	1
Shahzad, S	1
Abbas, M	1
Mehmood, T	1
Anwar, F	1
Aslam, B	1
Batool, M	1
Zahoor, B	1
Gohar, H	1
Latif, I	1
Zaib, M	1
Sharif, A	1
Akhtar, B	1
Khan, HM	1
Akhtar, MF	1
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