alloxan has been researched along with Erectile Dysfunction in 6 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To explore the possible relevance of endothelial nitric oxide synthase (eNOS) in the pathophysiology of erectile dysfunction (ED) associated with diabetes mellitus, we compared the catalytic activity, protein expression, and cellular localization of eNOS with those of neuronal nitric oxide synthase (nNOS) in the penis of rats with alloxan-induced diabetes." | 3.71 | Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat. ( Akingba, AG; Burnett, AL, 2001) |
| "To investigate the effect of alloxan-induced diabetes mellitus (DM, a major risk factor for erectile dysfunction and associated with impaired endothelial function) on the formation of nitric oxide (NO), prostacyclin (PGI2), cGMP and cAMP in the corpus cavernosum of rabbits." | 3.70 | Differential alterations of prostacyclin, cyclic AMP and cyclic GMP formation in the corpus cavernosum of the diabetic rabbit. ( Angelini, GD; Jeremy, JY; Mikhailidis, DP; Morgan, RJ; Sullivan, M; Thompson, CS, 1998) |
| "Moreover, treating hypogonadism in course of diabetes may maintain erectile function also by normalizing RhoA/ROCK pathway upregulation." | 1.34 | Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes. ( Ambrosini, S; Filippi, S; Forti, G; Luconi, M; Maggi, M; Mancina, R; Morelli, A; Mungai, S; Vannelli, GB; Vignozzi, L; Zhang, XH, 2007) |
| " Conversely, each rats group was further subdivided: no further treatment or acute sildenafil dosing (25 mg/kg, 1 hour before "in vivo" electrical stimulation [ES])." | 1.33 | Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. ( Donati, S; Filippi, S; Forti, G; Luconi, M; Maggi, M; Morelli, A; Vignozzi, L; Zhang, XH, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, XH | 2 |
| Filippi, S | 2 |
| Morelli, A | 2 |
| Vignozzi, L | 2 |
| Luconi, M | 2 |
| Donati, S | 1 |
| Forti, G | 2 |
| Maggi, M | 2 |
| Ambrosini, S | 1 |
| Mancina, R | 1 |
| Mungai, S | 1 |
| Vannelli, GB | 1 |
| Sullivan, M | 1 |
| Thompson, CS | 2 |
| Mikhailidis, DP | 1 |
| Morgan, RJ | 2 |
| Angelini, GD | 1 |
| Jeremy, JY | 2 |
| Khan, MA | 1 |
| Mumtaz, FH | 1 |
| Mikhailidis, P | 1 |
| Taher, A | 1 |
| Birowo, P | 1 |
| Kamil, ST | 1 |
| Shahab, N | 1 |
| Akingba, AG | 1 |
| Burnett, AL | 1 |
6 other studies available for alloxan and Erectile Dysfunction
| Article | Year |
|---|---|
Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alloxan; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5; | 2006 |
Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes.
Topics: Alloxan; Amides; Animals; Blotting, Western; Diabetes Mellitus, Experimental; Disease Models, Animal | 2007 |
Differential alterations of prostacyclin, cyclic AMP and cyclic GMP formation in the corpus cavernosum of the diabetic rabbit.
Topics: Alloxan; Animals; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; Epoprostenol; Erectile Dy | 1998 |
The effect of superoxide dismutase on nitric oxide-mediated and electrical field-stimulated diabetic rabbit cavernosal smooth muscle relaxation.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Electric Stimulation; Erectile Dysfunction; Male; | 2001 |
Relaxation effect of nitric oxide-donor on diabetic penile smooth muscle in vitro.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alloxan; Animals; Cyclic GMP; Cyclic Nucleotide Phosphodiestera | 2000 |
Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Erectile Dysfunction; Imm | 2001 |