alloxan and Disease Models, Animal studies

Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
"Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis."	8.12	High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022)
" We investigated whether increases in the duration of hyperglycemia result in the development of corneal lesions in a mouse model of alloxan (AL)- or streptozotocin (STZ)-induced type 1 diabetes."	7.88	Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes. ( Matsuura, T; Ozaki, K; Terayama, Y, 2018)
"To investigate the effects of alloxan diabetes on the abdominal wall healing of rats undergoing laparotomy."	7.80	Alloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in rats. ( Caramori, CA; Hasimoto, CN; Lima, Fde O; Minossi, JG; Ortolan, EV; Rodrigues, PA; Spadella, CT, 2014)
"The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats."	7.80	The protective effect of vanadium against diabetic cataracts in diabetic rat model. ( Gao, XC; Han, Q; Mi, SY; Shi, DJ; Sun, L; Yu, Y, 2014)
" The alloxan-induced diabetic rabbit ear ulcer model was used to determine healing in response to the following treatments: collagen seeded with autologous circulating angiogenic cells exposed to osteopontin, collagen seeded with autologous circulating angiogenic cells, collagen alone and untreated wound."	7.79	Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model. ( Creane, M; Dockery, P; Kulkarni, M; Liew, A; O'Brien, T; O'Loughlin, A; Pandit, A; Vaughan, EE, 2013)
" In the current manuscript, we studied the effect of pyridoxamine (PM) on protein glycation, oxidative stress, interleukin-1α (IL-1α), IL-6, C-reactive protein (CRP), gene expression of tumour necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in relation to microalbuminuria and kidney functions in a model of alloxan-induced diabetic rats."	7.79	Pyridoxamine, an inhibitor of protein glycation, in relation to microalbuminuria and proinflammatory cytokines in experimental diabetic nephropathy. ( Elseweidy, MM; Elswefy, SE; Younis, NN; Zaghloul, MS, 2013)
"Using the methods of light and electron microscopy, pancreas was studied in the experimental model (Rats-30) of alloxan diabetes - one month from alloxan injection and after the action of Plaferon LB (amniotic interferon)."	7.77	Β-cells of rats pancreas and their supposed precursors during alloxan diabetes and after the action of Plaferon LB. ( Gachechiladze, I; Gvamichava, T; Kavtiashvili, K; Latsabidze, I; Machavariani, T, 2011)
"Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state."	7.77	Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011)
"to evaluate structural and functional effects of Alloxan- induced diabetes and aging on bladder of rats."	7.74	Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats. ( Cologna, AJ; Fazan, VP; Foss, MC; Martins, AC; Rodrigues, AA; Suaid, HJ; Tucci, S, 2008)
"To compare the contact lens-induced corneal edema recovery dynamics of human subjects with type 1 diabetes with those of age- and sex-matched normal human subjects; to compare the human data with previously reported data from alloxan-induced diabetic rabbit."	7.69	Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model? ( Herse, P; Hooker, B, 1994)
" We have used this model system to investigate whether 5 to 9 weeks of alloxan-induced hyperglycemia increases platelet adhesion and aggregation on a damaged vessel wall in vivo as well as platelet aggregation in vitro."	7.67	Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo. ( Ingerman-Wojenski, CM; Silver, MJ; Smith, M, 1987)
"Alloxan monohydrate was used for induction of diabetes."	5.40	Allogenous skin fibroblast transplantation enhances excisional wound healing following alloxan diabetes in sheep, a randomized controlled trial. ( Dalir-Naghadeh, B; Farshid, AA; Kazemi-Darabadi, S; Sarrafzadeh-Rezaei, F, 2014)
"On the basis of these data, alloxan diabetes is not transmissible in Yucatan pigs in the same way that it is in rats."	5.26	The effects of alloxan diabetes on Yucatan miniature swine and their progeny. ( Case, GL; Panepinto, LM; Phillips, RW; Will, DH, 1980)
"Carnitine deficiency and impaired glucose tolerance (IGT) exacerbate liver steatosis."	4.12	High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. ( Matsuura, T; Mekada, K; Nakamura, SI; Ozaki, K; Terayama, Y, 2022)
" We investigated whether increases in the duration of hyperglycemia result in the development of corneal lesions in a mouse model of alloxan (AL)- or streptozotocin (STZ)-induced type 1 diabetes."	3.88	Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes. ( Matsuura, T; Ozaki, K; Terayama, Y, 2018)
" Body weight, fasting blood glucose, hepatic glycogen, serum insulin, and serum glucagon were determined by electronic scales, glucometer, and ELISA kits."	3.85	Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice. ( Chen, J; Fu, H; Huan, M; Qiu, G; Tian, W, 2017)
"The present study was designed to investigate the effect of vanadium in alloxan-induced diabetes and cataract in rats."	3.80	The protective effect of vanadium against diabetic cataracts in diabetic rat model. ( Gao, XC; Han, Q; Mi, SY; Shi, DJ; Sun, L; Yu, Y, 2014)
"To investigate the effects of alloxan diabetes on the abdominal wall healing of rats undergoing laparotomy."	3.80	Alloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in rats. ( Caramori, CA; Hasimoto, CN; Lima, Fde O; Minossi, JG; Ortolan, EV; Rodrigues, PA; Spadella, CT, 2014)
" Type 1 diabetes was induced in C57Bl/6, NMRI, BALB/c, and 129Sv mice by alloxan, and conscious glomerular filtration rate, proteinuria, and oxidative stress levels were measured in control and diabetic animals at baseline and after 5 and 10 wk."	3.80	Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes. ( Fasching, A; Franzén, S; Friederich-Persson, M; Hansell, P; Nangaku, M; Palm, F, 2014)
" In the current manuscript, we studied the effect of pyridoxamine (PM) on protein glycation, oxidative stress, interleukin-1α (IL-1α), IL-6, C-reactive protein (CRP), gene expression of tumour necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in relation to microalbuminuria and kidney functions in a model of alloxan-induced diabetic rats."	3.79	Pyridoxamine, an inhibitor of protein glycation, in relation to microalbuminuria and proinflammatory cytokines in experimental diabetic nephropathy. ( Elseweidy, MM; Elswefy, SE; Younis, NN; Zaghloul, MS, 2013)
" The alloxan-induced diabetic rabbit ear ulcer model was used to determine healing in response to the following treatments: collagen seeded with autologous circulating angiogenic cells exposed to osteopontin, collagen seeded with autologous circulating angiogenic cells, collagen alone and untreated wound."	3.79	Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model. ( Creane, M; Dockery, P; Kulkarni, M; Liew, A; O'Brien, T; O'Loughlin, A; Pandit, A; Vaughan, EE, 2013)
"The purpose of this study was to investigate the effects of hyperglycemia on atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation (AF) in alloxan-induced diabetic rabbits."	3.78	Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits. ( Cheng, L; Fu, H; Li, G; Li, J; Liu, C; Liu, T; Yang, W, 2012)
"Alloxan and oxidative stress, which have been detected in livers of laboratory animals shortly after in vivo alloxan administration, cause in vitro mitochondrial dysfunction, thus questioning alloxan diabetes as an acceptable model for type 1 diabetes, a model that cannot legitimately be used to investigate mitochondrial metabolism in a diabetic state."	3.77	Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? ( Alvarez-Bustamante, JA; Rendon, DA, 2011)
"Using the methods of light and electron microscopy, pancreas was studied in the experimental model (Rats-30) of alloxan diabetes - one month from alloxan injection and after the action of Plaferon LB (amniotic interferon)."	3.77	Β-cells of rats pancreas and their supposed precursors during alloxan diabetes and after the action of Plaferon LB. ( Gachechiladze, I; Gvamichava, T; Kavtiashvili, K; Latsabidze, I; Machavariani, T, 2011)
" To examine whether insulin influences the development of inflammation in the alveolar septa, diabetic male Wistar rats (alloxan, 42 mg/kg, i."	3.77	Insulin modulates inflammatory and repair responses to elastase-induced emphysema in diabetic rats. ( Capelozzi, VL; Castro, EO; Di Petta, A; Greco, KV; Lopes, FD; Martins, MA; Moreira, LF; Sannomiya, P, 2011)
" We therefore carried out a preliminary study to assess the effect of prior administration of Magnesium on induction of alloxan diabetes, a model of type 1 diabetes mellitus."	3.76	Pretreatment effect of magnesium on alloxan induced hyperglycemia in rats. ( Adewoye, EO; Ige, OA; Olaleye, SB; Salami, AT, 2010)
"to evaluate structural and functional effects of Alloxan- induced diabetes and aging on bladder of rats."	3.74	Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats. ( Cologna, AJ; Fazan, VP; Foss, MC; Martins, AC; Rodrigues, AA; Suaid, HJ; Tucci, S, 2008)
" Here we show that alloxan-induced in vitro cytotoxicity and apoptosis in an insulin secreting rat insulinoma, RIN, cells can be prevented by arachidonic acid (AA) and that both cyclo-oxygenase and lipoxygenase inhibitors do not block this protective action."	3.71	Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. ( Das, UN; Suresh, Y, 2001)
" Using an animal model of diabetes (alloxan-induced hyperglycaemia in mice), a model of gastric ulcer (indomethacin-induced gastric lesion in rats), and a model of bronchial asthma (ovalbumin-induced allergic bronchospasm in guinea pigs), a potential therapeutic effect was tested in known antioxidant drugs (alpha-tocopherol, ubiquinone), the thio-compound mesna, and drugs with a possible antioxidant effect (substances derived from the ergoline structure: 6-hydroxynicotinic acid and 4-hydroxypyridine)."	3.70	Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). ( Grossmann, V; Stetinová, V, 2000)
"To compare the contact lens-induced corneal edema recovery dynamics of human subjects with type 1 diabetes with those of age- and sex-matched normal human subjects; to compare the human data with previously reported data from alloxan-induced diabetic rabbit."	3.69	Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model? ( Herse, P; Hooker, B, 1994)
"25 female sheep of the Texel breed were made hyperglycaemic by administration of alloxan monohydrate (ALX) in early pregnancy and 15 ewes served as controls."	3.67	Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization. ( Eskes, TK; Jongsma, HW; Lips, JP, 1988)
" We have used this model system to investigate whether 5 to 9 weeks of alloxan-induced hyperglycemia increases platelet adhesion and aggregation on a damaged vessel wall in vivo as well as platelet aggregation in vitro."	3.67	Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo. ( Ingerman-Wojenski, CM; Silver, MJ; Smith, M, 1987)
"Ketamine was shown to be capable of increasing the activity of acetylcholinesterase (AChE) in the brain structures."	1.46	Pre-clinical investigation of Diabetes Mellitus as a risk factor for schizophrenia. ( Canever, L; Damiani, AP; de Andrade, VM; Fachim, I; Gomes, ST; Gress, K; Heylmann, ASA; Mastella, GA; Michels, C; Quevedo, J; Steckert, AV; Stopassoli, GC; Zugno, AI, 2017)
"Anxiety, fear, and anhedonia are mediated by interactions between different deep structures of the temporal lobe (e."	1.43	Widespread blunting of hypothalamic and amygdala-septal activity and behavior in rats with long-term hyperglycemia. ( Contreras, CM; Guillén-Ruiz, G; Gutiérrez-García, AG; Moreno-Cortés, ML; Romo-González, T, 2016)
"Nonalcoholic fatty liver disease (NAFLD) occurs in approximately 80% of cases of type 2 diabetes mellitus (T2DM)."	1.42	Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in obese diabetic albino rats. ( Mohamed, KM; Mohamed, WS; Mostafa, AM; Serwah, AH, 2015)
"Hyperglycemia is the primary cause of the majority of diabetes complications, including diabetic retinopathy (DR)."	1.40	Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. ( Gurel, Z; Pratt, MR; Sheibani, N; Zaro, BW, 2014)
"Alloxan monohydrate was used for induction of diabetes."	1.40	Allogenous skin fibroblast transplantation enhances excisional wound healing following alloxan diabetes in sheep, a randomized controlled trial. ( Dalir-Naghadeh, B; Farshid, AA; Kazemi-Darabadi, S; Sarrafzadeh-Rezaei, F, 2014)
"Alloxan-treated dogs (D; n=7) were maintained normoglycemic using 24-h/d IV insulin replacement."	1.38	Chronic intrarenal insulin replacement reverses diabetes mellitus-induced natriuresis and diuresis. ( Brands, MW; Duggan, AD; Manhiani, MM; Wilson, H, 2012)
"Alloxan treatment reduced HSP90 levels and promoted proteasomal degradation of tau, c-Jun N-amino terminal kinase, and histone deacetylase (HDAC) 6."	1.38	Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes. ( Kimura, T; Maeda, S; Mizoroki, T; Murayama, M; Sahara, N; Soeda, Y; Takashima, A; Yamashita, S; Yoshiike, Y, 2012)
"Alloxan-diabetic rats were treated or not with NAC for four weeks."	1.36	Oxidative stress is not associated with vascular dysfunction in a model of alloxan-induced diabetic rats. ( Baldo, CF; Batalhão, ME; Capellini, VK; Cárnio, EC; Celotto, AC; Evora, PR; Rodrigues, AJ, 2010)
"In alloxan-treated mice (a model of type 1 diabetes), drugs were administered orally once daily for 6 days post-alloxan treatment."	1.35	Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. ( Jiang, J; Larrick, JW; Wang, Y; Yu, P; Zeng, X; Zhang, Z, 2009)
"Moreover, treating hypogonadism in course of diabetes may maintain erectile function also by normalizing RhoA/ROCK pathway upregulation."	1.34	Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes. ( Ambrosini, S; Filippi, S; Forti, G; Luconi, M; Maggi, M; Mancina, R; Morelli, A; Mungai, S; Vannelli, GB; Vignozzi, L; Zhang, XH, 2007)
" The tests of maximum dosage and acute toxicity showed that EJA-1 was safe (MD = 360 g/kg, LD(50) = 400."	1.34	Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae. ( Chen, J; Li, WL; Lu, CG; Ren, BR; Wu, JL, 2007)
"Alloxan was used to induce diabetes in male Watanabe heritable hyperlipidemic (WHHL) rabbits that were sacrificed 2 and 6 months after the induction of diabetes."	1.33	VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits. ( Ahtialansaari, T; Babu, M; Bhardwaj, S; Hakumaki, J; Herzig, KH; Kokina, I; Laakso, M; Laitinen, T; Roy, H; Uotila, S; Ylä-Herttuala, S, 2006)
" Conversely, each rats group was further subdivided: no further treatment or acute sildenafil dosing (25 mg/kg, 1 hour before "in vivo" electrical stimulation [ES])."	1.33	Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. ( Donati, S; Filippi, S; Forti, G; Luconi, M; Maggi, M; Morelli, A; Vignozzi, L; Zhang, XH, 2006)
"We aimed to characterize the enamel hypoplasia in Wistar rats born to alloxan-induced diabetes mellitus rats."	1.32	Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus. ( Foss, MC; Peres, LC; Silva-Sousa, YT, 2003)
"Stress hyperglycemia is frequent in critically ill patients."	1.32	Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. ( Coopmans, W; Giulietti, AP; Mathieu, C; Michalaki, M; Van den Berghe, G; Van Herck, E; Weekers, F, 2003)
" Alloxan-streptozotocin combination administration reduced the dosage of each drug, and decreased the toxic and side effect of each drug."	1.31	[Chemically induced (streptozotocin-alloxan) diabetes mellitus in dogs]. ( Liu, S; Luo, XM; Wang, W; Ye, B, 2000)
"Postprandial dyslipidemia may be a major cause of atherosclerosis in diabetes."	1.31	Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes. ( Anderton, K; Bennett, A; Collins, P; Owens, D; Phillips, C; Tomkin, GH; White, D, 2002)
"Alloxan-treated controls had similar results to age-matched controls."	1.30	Upregulation of endothelin A receptor sites in the rabbit diabetic kidney: potential relevance to the early pathogenesis of diabetic nephropathy. ( Dashwood, MR; Khan, MA; Mikhailidis, DP; Morgan, RJ; Mumtaz, FH; Thompson, CS, 1999)
" The best known diabetogenic substances, Streptozotocin and Alloxan are described, including their usage, dosage dosing intervals, and mechanism of action."	1.29	[Experimental models in research of the pathomechanism of diabetes mellitus]. ( Fehér, J; Prechl, J; Pusztai, P; Somogyi, A; Szaleczky, E, 1996)
"Treatment of alloxan-diabetic mice with insulin in vivo completely reversed all immune defects, while insulin treatment of streptozotocin-diabetic mice restored immune function to only 70-80% of normal levels."	1.27	Assessment of the diabetogenic drugs alloxan and streptozotocin as models for the study of immune defects in diabetic mice. ( Eardley, DD; Gaulton, GN; Schwartz, JL, 1985)
" Our study was designed to explore dosage schedules which might improve rabbit responsiveness to and survival after alloxan treatment."	1.27	Variations of susceptibility to alloxan induced diabetes in the rabbit. ( Beyer, MM; Brown, CD; Friedman, EA; Watschinger, B; Zhao, ZH, 1987)
"Alloxan (200 mg/kg) was injected i."	1.27	The partially diabetic pancreas: a histological study of a new animal model. ( Davidson, PM; Foulis, AK; Meehan, CJ; Young, DG, 1987)
"On the basis of these data, alloxan diabetes is not transmissible in Yucatan pigs in the same way that it is in rats."	1.26	The effects of alloxan diabetes on Yucatan miniature swine and their progeny. ( Case, GL; Panepinto, LM; Phillips, RW; Will, DH, 1980)
"5 times increased molar dosage required to produce islet NAD depression comparable to that of streptozotocin, 150 mg/kg."	1.25	Streptozotocin diabetes. Correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide. ( Anderson, T; Cooney, DA; McMenamin, MG; Schein, PS, 1974)

Research

Studies (149)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change From Baseline Collagen Formation (Collagen Content ) at 6 Weeks

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (16.11)	18.7374
1990's	16 (10.74)	18.2507
2000's	48 (32.21)	29.6817
2010's	50 (33.56)	24.3611
2020's	11 (7.38)	2.80

Authors	Studies
Samidurai, A	1
Ockaili, R	1
Cain, C	1
Roh, SK	1
Filippone, SM	1
Kraskauskas, D	1
Kukreja, RC	1
Das, A	1
Sosa Crespo, I	1
Chel Guerrero, L	1
Acevedo Fernández, JJ	1
Negrete León, E	1
Betancur Ancona, D	1
Terayama, Y	2
Nakamura, SI	1
Mekada, K	1
Matsuura, T	3
Ozaki, K	3
Imtiaz, F	1
Islam, M	1
Saeed, H	1
Ahmed, A	1
Rathore, HA	1
Balmer, LA	1
Whiting, R	1
Rudnicka, C	1
Gallo, LA	1
Jandeleit, KA	1
Chow, Y	1
Chow, Z	1
Richardson, KL	1
Forbes, JM	1
Morahan, G	1
Nasreen, W	1
Sarker, S	1
Sufian, MA	1
Md Opo, FAD	1
Shahriar, M	1
Akhter, R	1
Halim, MA	1
Liu, L	1
Wang, X	1
Zhou, Y	3
Cai, M	1
Lin, K	1
Fang, B	1
Xia, L	1
Iftikhar, A	1
Aslam, B	1
Iftikhar, M	1
Majeed, W	1
Batool, M	1
Zahoor, B	1
Amna, N	1
Gohar, H	1
Latif, I	1
El-Sherbeeny, NA	1
Ibrahiem, AT	1
Ali, HS	1
Farag, NE	1
Toraih, EA	1
Zaitone, SA	1
Samadder, A	1
Dey, S	1
Sow, P	1
Das, R	1
Nandi, S	1
Das, J	1
Bhattacharjee, B	1
Chakrovorty, A	1
Biswas, M	1
Guptaroy, P	1
França-Silva, N	1
Reis, NG	1
Santos, PF	1
Balbi, APC	1
Hu, L	1
Zha, YF	1
Wang, L	1
Li, L	1
Xing, D	1
Gong, W	1
Wang, J	2
Lin, Y	1
Zeng, FF	1
Lu, XS	1
Ighodaro, OM	1
Adeosun, AM	1
Akinloye, OA	1
Rehman, K	1
Chohan, TA	1
Waheed, I	1
Gilani, Z	1
Akash, MSH	1
Ajiboye, BO	1
Oloyede, HOB	1
Salawu, MO	1
de Azevedo Queiroz, ÍO	1
Gonçalves, LO	1
Takamiya, AS	1
Rezende, GC	1
Machado, T	1
Siveiri-Araujo, G	1
Ervolino, E	1
Oliveira, SHP	1
Gomes-Filho, JE	1
Reis, FP	1
Sementilli, A	1
Gagliardi, AR	1
Elseweidy, MM	1
Elswefy, SE	1
Younis, NN	1
Zaghloul, MS	1
Stančić, A	1
Otašević, V	1
Janković, A	1
Vučetić, M	1
Ivanović-Burmazović, I	1
Filipović, MR	1
Korać, A	1
Markelić, M	1
Veličković, K	1
Golić, I	1
Buzadžić, B	1
Korać, B	1
Schindler, M	1
Pendzialek, M	1
Navarrete Santos, A	1
Plösch, T	1
Seyring, S	1
Gürke, J	1
Haucke, E	1
Knelangen, JM	1
Fischer, B	1
Santos, AN	1
O'Loughlin, A	1
Kulkarni, M	1
Vaughan, EE	1
Creane, M	1
Liew, A	1
Dockery, P	1
Pandit, A	1
O'Brien, T	1
Sun, L	1
Shi, DJ	1
Gao, XC	1
Mi, SY	1
Yu, Y	1
Han, Q	1
Minossi, JG	1
Lima, Fde O	1
Caramori, CA	1
Hasimoto, CN	1
Ortolan, EV	1
Rodrigues, PA	1
Spadella, CT	2
Achar, RA	1
Silva, TC	1
Achar, E	1
Martines, RB	1
Machado, JL	1
Franzén, S	1
Friederich-Persson, M	1
Fasching, A	1
Hansell, P	1
Nangaku, M	1
Palm, F	1
Gurel, Z	1
Zaro, BW	1
Pratt, MR	1
Sheibani, N	1
Zeng, Z	1
Zhu, BH	1
Kazemi-Darabadi, S	1
Sarrafzadeh-Rezaei, F	1
Farshid, AA	1
Dalir-Naghadeh, B	1
Mukhopadhyay, P	1
Sarkar, K	1
Chakraborty, M	1
Bhattacharya, S	1
Mishra, R	1
Kundu, PP	1
Mohamed, WS	1
Mostafa, AM	1
Mohamed, KM	1
Serwah, AH	1
Lucchesi, AN	1
Cassettari, LL	1
Boudjelal, A	1
Siracusa, L	1
Henchiri, C	1
Sarri, M	1
Abderrahim, B	1
Baali, F	1
Ruberto, G	1
Guo, Q	1
Zhu, HY	1
Jin, L	1
Gao, QS	1
Kang, JD	1
Cui, CD	1
Yin, XJ	1
Tang, RQ	1
Zhang, XL	1
Tian, JY	1
Kong, SM	1
Zhang, P	1
Yang, HK	1
Wu, S	2
Zhang, Y	1
Ye, F	1
Díaz-Roa, A	1
Gaona, MA	1
Segura, NA	1
Ramírez-Hernández, A	1
Cortés-Vecino, JA	1
Patarroyo, MA	1
Bello, F	1
Du, L	1
Liu, C	2
Teng, M	1
Meng, Q	1
Lu, J	1
Liu, Y	1
Cheng, Y	1
Wang, D	1
Teng, L	1
Moreno-Cortés, ML	1
Gutiérrez-García, AG	1
Guillén-Ruiz, G	1
Romo-González, T	1
Contreras, CM	1
Qiu, G	1
Tian, W	1
Huan, M	1
Chen, J	3
Fu, H	2
Jiang, B	1
Ji, M	1
Liu, W	1
Chen, L	1
Cai, Z	1
Zhao, Y	1
Bi, X	1
Hu, AM	1
Zhu, T	1
Jiang, Y	1
Dong, L	1
Gao, H	1
DU, GZ	1
Heylmann, ASA	1
Canever, L	1
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Trial	Enrollment	Study Type	Start Date	Status
Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): A Randomized Controlled Trial[NCT04633642]	51 participants (Actual)	Interventional	2017-11-01	Completed
Determining the Factors That Affects Emergency Department Visits of Hyperglycemic Patients in 30 Days.[NCT04665128]	120 participants (Anticipated)	Observational	2020-12-15	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Massons's trichome staining was used to differentiate collagen content from other components, such as muscle fibrin and erythrocytes, in tissue samples. Collagen content was scored according to the following scale: 0 (absent), 1 (mild), 2 (moderate) and 3 (severe). Higher scores mean a better outcome. (NCT04633642)
Timeframe: At week zero and week 6

Change From Baseline Myofibroblasts Formation (Myofibroblasts Content) at 6 Weeks

Intervention	score on a scale (Mean)
Ultrasound Group (UAW Group)	2.81
Surgical Group	1.20

Actin staining was used to evaluate the presence of myofibroblasts involved in wound healing. These cells increase in number during wound healing. The number of stained cells was semi-quantitatively analyzed using a 0 - 3 scaling score (0= no myofibroblasts, 1= myofibroblasts in low quantity, 2= myofibroblasts in moderate quantity, 3= myofibroblasts in high quantity) (NCT04633642)
Timeframe: At week zero and week 6

Change From Baseline Neo-angiogenesis (Microvessel Density) at 6 Weeks

Intervention	score on a scale (Mean)
Ultrasound Group (UAW Group)	2.56
Surgical Group	2.00

"Sections of tissue were immunohistochemically-stained with the CD31 marker. Light microscopy was used to count the number of microvessels/endothelial cells in a standardized grid, with the results expressed as microvessel density (Leica DMD 800 morphometric system). Microvessel density was scored according to the following scale: 0 (absent), 1 (low, at least one microvessel), 2 (moderate) and 3 (more than two micro vessels).~Higher scores mean a better outcome" (NCT04633642)
Timeframe: At week zero and week 6

Comparison of Quantitative Microbiological Analysis (Bacterial Counts Expressed Colony-forming Units Per Gram of Tissue) (CFU/g)

Intervention	score on a scale (Mean)
Ultrasound Group (UAW Group)	2.82
Surgical Group	1.77

Tissue samples were weighed and mechanically homogenised in 0.5ml volumes of sterile phosphate buffered saline (PBS, Sigma Aldrich, St Louis, MO). Homogenates were diluted and plated onto Columbia agar (BD, Sparks, MD), Columbia agar supplemented with colistin and nalidixic acid (BD), MacConkey agar (BD), and Sabouraud dextrose agar (BD) using a spiral plater workstation (Don Whitley Scientific, Shipley, UK).The limit of detection was 10 colony-forming units (CFU). Results were expressed as CFU per gram of tissue (CFU/g). Isolated microorganisms were identified by standard criteria and the BBL Crystal identification system (BD). Susceptibility testing of Staphylococcus aureus isolates for oxacillin was performed according to Clinical and Laboratory Standards Institute (CLSI) guidelines, using a 30g cefoxitin disc and Mueller-Hinton agar . (NCT04633642)
Timeframe: At week zero and week 6

Wound Score at 6 Weeks

Intervention	Log10 CFU/g (Mean)
Ultrasound Group (UAW Group)	2.11
Surgical Group	4.39

Wound bed tissue was evaluated for presence, quality, and consistency of granulation tissue using a validated wound scoring system, with scores ranging between a minimum of zero points and maximum of seven points. Higher scores mean a better outcome. (NCT04633642)
Timeframe: Six weeks

Wound Size

Intervention	score on a scale (Mean)
Ultrasound Group (UAW Group)	5.4
Surgical Group	5.6

A planimetric measurements of wound size were conducted using Visitrak (Smith & Nephew, Hull, UK), with the area of the lesion determined with an approximation of ±5mm2 (NCT04633642)
Timeframe: 6 weeks

Article	Year
Alloxan-induced diabetes, a common model for evaluating the glycemic-control potential of therapeutic compounds and plants extracts in experimental studies. Medicina (Kaunas, Lithuania), 2017, Volume: 53, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Mo	2017
[Drug-induced animal models of diabetes]. Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 8 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Rats; Streptozocin	2002
Induction of type-1 diabetes mellitus in laboratory rats by use of alloxan: route of administration, pitfalls, and insulin treatment. Comparative medicine, 2004, Volume: 54, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Insulin; Rats	2004
Islet transplantation. Surgery, gynecology & obstetrics, 1977, Volume: 145, Issue:5 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus; Diabetes M	1977

Article	Year
Preclinical model of type 1 diabetes and myocardial ischemia/reperfusion injury in conscious rabbits-demonstration of cardioprotection with rapamycin. STAR protocols, 2021, 09-17, Volume: 2, Issue:3 Topics: Alloxan; Animals; Apoptosis; Balloon Occlusion; Cardiotonic Agents; Diabetes Mellitus, Experimental;	2021
[Evaluation of the hypoglycemic effect of a peptide fraction of chia seeds (Salvia hispánica L.) in male Wistar rats induced with alloxan]. Nutricion hospitalaria, 2021, Dec-09, Volume: 38, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypoglycem	2021
High-fat diet-induced nonalcoholic steatohepatitis is accelerated by low carnitine and impaired glucose tolerance in novel murine models. Laboratory investigation; a journal of technical methods and pathology, 2022, Volume: 102, Issue:6 Topics: Alloxan; Animals; Carcinogenesis; Carnitine; Diet, High-Fat; Disease Models, Animal; Glucose Intoler	2022
Assessment of the antidiabetic potential of extract and novel phytoniosomes formulation of Tradescantia pallida leaves in the alloxan-induced diabetic mouse model. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2023, Volume: 37, Issue:4 Topics: Alloxan; alpha-Glucosidases; Animals; Body Weight; Diabetes Mellitus, Experimental; Disease Models,	2023
Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease. Kidney international, 2019, Volume: 96, Issue:4 Topics: Aldehyde Reductase; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disea	2019
A possible alternative therapy for type 2 diabetes using Myristica fragrans Houtt in combination with glimepiride: in vivo evaluation and in silico support. Zeitschrift fur Naturforschung. C, Journal of biosciences, 2020, Mar-26, Volume: 75, Issue:3-4 Topics: Alloxan; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, Combination; Fema	2020
The synergistic promotion of osseointegration by nanostructure design and silicon substitution of hydroxyapatite coatings in a diabetic model. Journal of materials chemistry. B, 2020, 04-08, Volume: 8, Issue:14 Topics: Alloxan; Animals; Coated Materials, Biocompatible; Diabetes Mellitus, Experimental; Diabetes Mellitu	2020
Effect of Caesalpinia bonduc Polyphenol Extract on Alloxan-Induced Diabetic Rats in Attenuating Hyperglycemia by Upregulating Insulin Secretion and Inhibiting JNK Signaling Pathway. Oxidative medicine and cellular longevity, 2020, Volume: 2020 Topics: Alloxan; Animals; Caesalpinia; Diabetes Mellitus, Experimental; Disease Models, Animal; Herbal Medic	2020
Carbamazepine conquers spinal GAP43 deficiency and sciatic Nav1.5 upregulation in diabetic mice: novel mechanisms in alleviating allodynia and hyperalgesia. Archives of pharmacal research, 2020, Volume: 43, Issue:7 Topics: Alloxan; Animals; Carbamazepine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Mod	2020
Phyto-chlorophyllin Prevents Food Additive Induced Genotoxicity and Mitochondrial Dysfunction via Cytochrome c Mediated Pathway in Mice Model. Combinatorial chemistry & high throughput screening, 2021, Volume: 24, Issue:10 Topics: Administration, Oral; Alloxan; Animals; Chlorophyllides; Cytochromes c; Cytogenetic Analysis; Diabet	2021
Diabetes and pregnancy in Wistar rats: renal effects for mothers in the postpartum period. Journal of developmental origins of health and disease, 2018, Volume: 9, Issue:1 Topics: Alloxan; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease M	2018
Quantitative Evaluation of Vertebral Microvascular Permeability and Fat Fraction in Alloxan-induced Diabetic Rabbits. Radiology, 2018, Volume: 287, Issue:1 Topics: Adipose Tissue; Alloxan; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Disease M	2018
Taxifolin prevents postprandial hyperglycemia by regulating the activity of α-amylase: Evidence from an in vivo and in silico studies. Journal of cellular biochemistry, 2019, Volume: 120, Issue:1 Topics: Acarbose; Alloxan; alpha-Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; B	2019
Antidiabetic Activity of Journal of dietary supplements, 2020, Volume: 17, Issue:2 Topics: Alloxan; Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Dioscorea; Disease Mod	2020
Extended Duration of Hyperglycemia Result in Human-Like Corneal Nerve Lesions in Mice With Alloxan- and Streptozotocin-Induced Type 1 Diabetes. Investigative ophthalmology & visual science, 2018, 12-03, Volume: 59, Issue:15 Topics: Alloxan; Animals; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Neuro	2018
Hyperglycemic condition influence on mineral trioxide aggregate biocompatibility and biomineralization. Journal of biomedical materials research. Part B, Applied biomaterials, 2020, Volume: 108, Issue:3 Topics: Alloxan; Aluminum Compounds; Animals; Biocompatible Materials; Biomineralization; Blood Glucose; Cal	2020
Experimental diabetes exacerbates skin transplant rejection in rats. Acta cirurgica brasileira, 2013, Volume: 28, Issue:5 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Graft Rejection;	2013
Pyridoxamine, an inhibitor of protein glycation, in relation to microalbuminuria and proinflammatory cytokines in experimental diabetic nephropathy. Experimental biology and medicine (Maywood, N.J.), 2013, Aug-01, Volume: 238, Issue:8 Topics: Albuminuria; Alloxan; Animals; C-Reactive Protein; Cytokines; Diabetes Mellitus, Experimental; Diabe	2013
Molecular basis of hippocampal energy metabolism in diabetic rats: the effects of SOD mimic. Brain research bulletin, 2013, Volume: 99 Topics: Alloxan; Animals; Cyclic GMP; Cytochromes c; Diabetes Mellitus, Experimental; Disease Models, Animal	2013
Maternal diabetes leads to unphysiological high lipid accumulation in rabbit preimplantation embryos. Endocrinology, 2014, Volume: 155, Issue:4 Topics: Alloxan; Animals; Blastocyst; Blood Glucose; Diabetes Mellitus, Type 1; Disease Models, Animal; Fatt	2014
Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model. Stem cell research & therapy, 2013, Volume: 4, Issue:6 Topics: Alloxan; Animals; Cells, Cultured; Collagen Type I; Diabetes Mellitus, Experimental; Disease Models,	2013
The protective effect of vanadium against diabetic cataracts in diabetic rat model. Biological trace element research, 2014, Volume: 158, Issue:2 Topics: Alloxan; Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hypergl	2014
Alloxan diabetes alters the tensile strength, morphological and morphometric parameters of abdominal wall healing in rats. Acta cirurgica brasileira, 2014, Volume: 29, Issue:2 Topics: Abdominal Wall; Alloxan; Animals; Blood Glucose; Cicatrix; Collagen; Diabetes Mellitus, Experimental	2014
Use of insulin-like growth factor in the healing of open wounds in diabetic and non-diabetic rats. Acta cirurgica brasileira, 2014, Volume: 29, Issue:2 Topics: Actins; Administration, Topical; Alloxan; Animals; Cell Proliferation; Diabetes Mellitus, Experiment	2014
Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes. American journal of physiology. Renal physiology, 2014, May-15, Volume: 306, Issue:10 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies	2014
Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy. PloS one, 2014, Volume: 9, Issue:5 Topics: Acetylglucosamine; Alloxan; Animals; Apoptosis; Diabetic Retinopathy; Disease Models, Animal; Endoth	2014
Arnebin-1 promotes the angiogenesis of human umbilical vein endothelial cells and accelerates the wound healing process in diabetic rats. Journal of ethnopharmacology, 2014, Jul-03, Volume: 154, Issue:3 Topics: Alloxan; Animals; Cell Proliferation; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Mode	2014
Allogenous skin fibroblast transplantation enhances excisional wound healing following alloxan diabetes in sheep, a randomized controlled trial. International journal of surgery (London, England), 2014, Volume: 12, Issue:8 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Fibroblasts; Male; Random	2014
Oral insulin delivery by self-assembled chitosan nanoparticles: in vitro and in vivo studies in diabetic animal model. Materials science & engineering. C, Materials for biological applications, 2013, Jan-01, Volume: 33, Issue:1 Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Chitosan; Diabetes Mellitus, Experimental; Di	2013
Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in obese diabetic albino rats. Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2015, Volume: 16, Issue:1 Topics: Adipose Tissue; Alloxan; Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Disease Mod	2015
Alloxan-induced diabetes causes morphological and ultrastructural changes in rat liver that resemble the natural history of chronic fatty liver disease in humans. Journal of diabetes research, 2015, Volume: 2015 Topics: Alanine Transaminase; Alloxan; Animals; Aspartate Aminotransferases; Body Weight; Cell Nucleus; Chro	2015
Antidiabetic Effects of Aqueous Infusions of Artemisia herba-alba and Ajuga iva in Alloxan-Induced Diabetic Rats. Planta medica, 2015, Volume: 81, Issue:9 Topics: Ajuga; Alloxan; Animals; Apigenin; Artemisia; Blood Glucose; Chlorogenic Acid; Diabetes Mellitus, Ex	2015
Production of Cloned Wuzhishan Miniature Pigs and Application for Alloxan Toxicity Test. Animal biotechnology, 2015, Volume: 26, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Cloning, Molecular; Diabetes Mellitus, Experimental; Disease Models	2015
[The effects of compound CX09040 on the inhibition of PTP1B and protection of pancreatic β cells]. Yao xue xue bao = Acta pharmaceutica Sinica, 2015, Volume: 50, Issue:6 Topics: Alloxan; Animals; Benzoates; Biological Assay; Disease Models, Animal; Glucose; Glucose Tolerance Te	2015
Evaluating Sarconesiopsis magellanica blowfly-derived larval therapy and comparing it to Lucilia sericata-derived therapy in an animal model. Acta tropica, 2016, Volume: 154 Topics: Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Diptera; Disease Models, A	2016
Anti-diabetic activities of Paecilomyces tenuipes N45 extract in alloxan-induced diabetic mice. Molecular medicine reports, 2016, Volume: 13, Issue:2 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease	2016
Widespread blunting of hypothalamic and amygdala-septal activity and behavior in rats with long-term hyperglycemia. Behavioural brain research, 2016, 09-01, Volume: 310 Topics: Alloxan; Amygdala; Anhedonia; Animals; Anxiety; Chronic Disease; Dietary Sucrose; Disease Models, An	2016
Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice. Experimental biology and medicine (Maywood, N.J.), 2017, Volume: 242, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty	2017
Antidiabetic activities of a cucurbitane‑type triterpenoid compound from Momordica charantia in alloxan‑induced diabetic mice. Molecular medicine reports, 2016, Volume: 14, Issue:5 Topics: Alloxan; Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal	2016
Establishment of An Alloxan-induced Diabetes Model in Daphnia Pulex. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2016, Dec-20, Volume: 38, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Daphnia; Diabetes Mellitus, Experimental; Disease Models, Animal; G	2016
Pre-clinical investigation of Diabetes Mellitus as a risk factor for schizophrenia. Behavioural brain research, 2017, 05-30, Volume: 326 Topics: Alloxan; Animals; Behavior, Animal; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type	2017
Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats. Acta cirurgica brasileira, 2008, Volume: 23 Suppl 1 Topics: Aging; Alloxan; Animals; Collagen; Cystotomy; Denervation; Diabetes Mellitus, Experimental; Disease	2008
Regulation of protein kinases and coregulatory interplay of S-100beta and serotonin transporter on serotonin levels in diabetic rat brain. Journal of neuroscience research, 2009, Volume: 87, Issue:1 Topics: Acetoacetates; Alloxan; Analysis of Variance; Animals; Blood Glucose; Brain; Carbonates; Diabetes Me	2009
Mechanism of action of the stimulatory effect of apigenin-6-C-(2''-O-alpha-l-rhamnopyranosyl)-beta-L-fucopyranoside on 14C-glucose uptake. Chemico-biological interactions, 2009, May-15, Volume: 179, Issue:2-3 Topics: Alloxan; Androstadienes; Animals; Biological Transport; Blood Glucose; Carbon Radioisotopes; Colchic	2009
Endocrine profile and testicular histomorphometry in adult rat offspring of diabetic mothers. The journal of physiological sciences : JPS, 2009, Volume: 59, Issue:5 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Anima	2009
Effect of aqueous extracts of alligator pear seed (Persea americana mill) on blood glucose and histopathology of pancreas in alloxan-induced diabetic rats. Pakistan journal of pharmaceutical sciences, 2009, Volume: 22, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Respo	2009
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. Journal of translational medicine, 2009, Jul-16, Volume: 7 Topics: Alloxan; Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus,	2009
Effect of chromium supplementation on the diabetes induced-oxidative stress in liver and brain of adult rats. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2009, Volume: 22, Issue:6 Topics: Alloxan; Animals; Brain; Catalase; Chromium; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dis	2009
Gene expression of pro-inflammatory cytokines and neuropeptides in diabetic wound healing. The Journal of surgical research, 2011, May-15, Volume: 167, Issue:2 Topics: Alloxan; Animals; Cytokines; Diabetes Mellitus, Experimental; Disease Models, Animal; Inflammation;	2011
The effects of diabetes and/or polymicrobial sepsis on the status of antioxidant enzymes and pro-inflammatory cytokines on heart, liver, and lung of ovariectomized rats. The Journal of surgical research, 2011, Volume: 169, Issue:1 Topics: Alloxan; Animals; Antioxidants; Catalase; Cytokines; Diabetes Mellitus, Experimental; Disease Models	2011
N-acetyl cysteine promotes angiogenesis and clearance of free oxygen radicals, thus improving wound healing in an alloxan-induced diabetic mouse model of incisional wound. Clinical and experimental dermatology, 2010, Volume: 35, Issue:8 Topics: Acetylcysteine; Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Free Radi	2010
Effects of diabetes mellitus on VEGF-induced proliferation response in bone marrow derived endothelial progenitor cells. Journal of cardiac surgery, 2010, Volume: 25, Issue:5 Topics: Alloxan; Animals; Blotting, Western; Bone Marrow Cells; Cell Movement; Cell Proliferation; Cell Surv	2010
Oxidative stress is not associated with vascular dysfunction in a model of alloxan-induced diabetic rats. Arquivos brasileiros de endocrinologia e metabologia, 2010, Volume: 54, Issue:6 Topics: Acetylcysteine; Alloxan; Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Disease Models,	2010
Hypoglycaemic action of stevioside and а barley and brewer's yeast based preparation in the experimental model on mice. Bosnian journal of basic medical sciences, 2011, Volume: 11, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Chromium; Diabetes Mellitus, Experimental; Disease Models, Animal;	2011
Intensive insulin treatment induces insulin resistance in diabetic rats by impairing glucose metabolism-related mechanisms in muscle and liver. The Journal of endocrinology, 2011, Volume: 211, Issue:1 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationshi	2011
Early hyperglycemia following alloxan administration in vivo is not associated with altered hepatic mitochondrial function: acceptable model for type 1 diabetes? Canadian journal of physiology and pharmacology, 2011, Volume: 89, Issue:7 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease	2011
[Cerebroprotective effect of 3-oxypyridine and succinic acid derivatives in acute phase of alloxan-induced diabetes mellitus in rats]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:5 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Anim	2011
Insulin modulates inflammatory and repair responses to elastase-induced emphysema in diabetic rats. International journal of experimental pathology, 2011, Volume: 92, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Cell Movement; Collagen; Comorbidity; Diabetes Mellitus, Experiment	2011
Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes. Aging cell, 2012, Volume: 11, Issue:1 Topics: Acetylation; Adaptation, Physiological; Aging; Alloxan; Animals; Disease Models, Animal; Female; His	2012
Insulin promotes bone formation in augmented maxillary sinus in diabetic rabbits. International journal of oral and maxillofacial surgery, 2012, Volume: 41, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Bone Substitutes; Cell Differentiation; Ceramics; Collagen; Collage	2012
Β-cells of rats pancreas and their supposed precursors during alloxan diabetes and after the action of Plaferon LB. Georgian medical news, 2011, Issue:198 Topics: Acinar Cells; Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Insulin; In	2011
Chronic intrarenal insulin replacement reverses diabetes mellitus-induced natriuresis and diuresis. Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Disease Models, An	2012
Vitis vinifera L. grape skin extract activates the insulin-signalling cascade and reduces hyperglycaemia in alloxan-induced diabetic mice. The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Blotting, Western; Body Weight; Diabetes Mellitus, Experimental; Di	2012
Pretreatment effect of magnesium on alloxan induced hyperglycemia in rats. African journal of medicine and medical sciences, 2010, Volume: 39 Suppl Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Injections	2010
Pacing postconditioning: impact of pacing algorithm, gender, and diabetes on its myocardial protective effects. Journal of cardiovascular translational research, 2012, Volume: 5, Issue:5 Topics: Algorithms; Alloxan; Animals; Cardiac Output; Cardiac Pacing, Artificial; Diabetes Mellitus, Experim	2012
Hyperglycemia aggravates atrial interstitial fibrosis, ionic remodeling and vulnerability to atrial fibrillation in diabetic rabbits. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2012, Volume: 12, Issue:7 Topics: Alloxan; Animals; Atrial Fibrillation; Atrial Remodeling; Diabetes Mellitus, Experimental; Disease M	2012
Ischemic preconditioning increases myocardial O-GlcNAc glycosylation. Scandinavian cardiovascular journal : SCJ, 2013, Volume: 47, Issue:3 Topics: Acetylglucosamine; Alloxan; Animals; Azaserine; Disease Models, Animal; Glycosylation; Hemodynamics;	2013
[Chemically induced (streptozotocin-alloxan) diabetes mellitus in dogs]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University, 2000, Apr-28, Volume: 25, Issue:2 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal	2000
Long-chain polyunsaturated fatty acids and diabetes mellitus. Nutrition (Burbank, Los Angeles County, Calif.), 2003, Volume: 19, Issue:2 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Fatty Acids, Unsaturated;	2003
Long-chain polyunsaturated fatty acids and chemically induced diabetes mellitus. Effect of omega-3 fatty acids. Nutrition (Burbank, Los Angeles County, Calif.), 2003, Volume: 19, Issue:3 Topics: Administration, Oral; Alloxan; alpha-Linolenic Acid; Animals; Antioxidants; Apoptosis; Diabetes Mell	2003
Antihyperglycemic effects of three extracts from Momordica charantia. Journal of ethnopharmacology, 2003, Volume: 88, Issue:1 Topics: Alloxan; Animal Structures; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Di	2003
Hypoglycemic effects of taurine in the alloxan-treated rabbit, a model for type 1 diabetes. Advances in experimental medicine and biology, 2003, Volume: 526 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypoglycem	2003
Metabolic, endocrine, and immune effects of stress hyperglycemia in a rabbit model of prolonged critical illness. Endocrinology, 2003, Volume: 144, Issue:12 Topics: Alloxan; Animals; Blood Gas Analysis; Blood Glucose; Body Weight; Burns; Critical Illness; Diabetes	2003
Enamel hypoplasia in a litter of rats with alloxan-induced diabetes mellitus. Brazilian dental journal, 2003, Volume: 14, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Dental Enamel Hypoplasia; Diabetes Mellitus, Experimental; Disease	2003
Evaluation of anti-hyperglycemic activity of some novel monocyclic beta lactams. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 2004, Apr-21, Volume: 7, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Hypoglycem	2004
Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats. Pharmacological research, 2004, Volume: 50, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Blood Proteins; Carbamates; Cholesterol, LDL; Diabetes Mellitus, Ex	2004
New experimental observation on the relationship of selenium and diabetes mellitus. Biological trace element research, 2004,Summer, Volume: 99, Issue:1-3 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Anima	2004
Hypoglycemic activity of Bauhinia candicans in diabetic induced rabbits. Fitoterapia, 2004, Volume: 75, Issue:6 Topics: Alloxan; Animals; Bauhinia; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal;	2004
The role of exercise on long-term effects of alloxan administered in neonatal rats. Experimental physiology, 2005, Volume: 90, Issue:1 Topics: Adaptation, Physiological; Alloxan; Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabetes	2005
[Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae)]. Dakar medical, 2000, Volume: 45, Issue:2 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Respo	2000
Differential effects of diabetes on CYP2E1 and CYP2B4 proteins and associated drug metabolizing enzyme activities in rabbit liver. Archives of toxicology, 2005, Volume: 79, Issue:8 Topics: Alloxan; Aniline Hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2E1; Cytoc	2005
Activity of angiotensin peptides in clitoral cavernosum of alloxan induced diabetic rabbit. European urology, 2005, Volume: 48, Issue:6 Topics: Alloxan; Angiotensins; Animals; Clitoris; Diabetes Mellitus, Experimental; Disease Models, Animal; F	2005
Central administration of alloxan impairs glucose tolerance in rats. Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:10 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose In	2005
Transcranial stimulation normalizes blood sugar levels in alloxan diabetes in rats. Neuroscience and behavioral physiology, 2006, Volume: 36, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Deep Brain Stimulation; Diabetes Mellitus, Experimental; Disease Mo	2006
Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes. The journal of sexual medicine, 2006, Volume: 3, Issue:2 Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alloxan; Animals; Cyclic Nucleotide Phosphodiesterases, Type 5;	2006
Critical role of cholic acid for development of hypercholesterolemia and gallstones in diabetic mice. Biochemical and biophysical research communications, 2006, Apr-21, Volume: 342, Issue:4 Topics: Alloxan; Animals; Cholesterol, Dietary; Cholic Acid; Diabetes Complications; Disease Models, Animal;	2006
Induction of squamous cell carcinoma of forestomach in diabetic rats by single alloxan treatment. Cancer science, 2006, Volume: 97, Issue:10 Topics: Alloxan; Animals; Bacteria; Blood Glucose; Candida albicans; Carcinoma, Squamous Cell; Cyclooxygenas	2006
VEGF-A, VEGF-D, VEGF receptor-1, VEGF receptor-2, NF-kappaB, and RAGE in atherosclerotic lesions of diabetic Watanabe heritable hyperlipidemic rabbits. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:12 Topics: Alloxan; Animals; Atherosclerosis; Diabetes Mellitus, Experimental; Disease Models, Animal; Hyperlip	2006
Chromium(III) complexes of D-glucosaminic acid and their effect on decreasing blood sugar in vivo. Archiv der Pharmazie, 2006, Volume: 339, Issue:9 Topics: Alloxan; Animals; Blood Glucose; Chromium Compounds; Diabetes Mellitus, Experimental; Disease Models	2006
Hypoglycemic effects of a sesquiterpene glycoside isolated from leaves of loquat (Eriobotrya japonica (Thunb.) Lindl.). Phytomedicine : international journal of phytotherapy and phytopharmacology, 2008, Volume: 15, Issue:1-2 Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Carbohydrate Sequence; Diabetes Mellitus, Exp	2008
Differences in expression of retinal proteins between diabetic and normal rats. World journal of gastroenterology, 2007, Apr-14, Volume: 13, Issue:14 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Models, Animal; Ele	2007
Testosterone regulates RhoA/Rho-kinase signaling in two distinct animal models of chemical diabetes. The journal of sexual medicine, 2007, Volume: 4, Issue:3 Topics: Alloxan; Amides; Animals; Blotting, Western; Diabetes Mellitus, Experimental; Disease Models, Animal	2007
Pharmacological studies on anti-hyperglycemic effect of folium eriobotryae. The American journal of Chinese medicine, 2007, Volume: 35, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Respo	2007
Insulinomimetic effect of kaempferol 3-neohesperidoside on the rat soleus muscle. Journal of natural products, 2008, Volume: 71, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Ferns; Gly	2008
Gastric motor effects of ghrelin and growth hormone releasing peptide 6 in diabetic mice with gastroparesis. World journal of gastroenterology, 2008, Mar-07, Volume: 14, Issue:9 Topics: Alloxan; Animals; Carbachol; Cholinergic Agents; Diabetes Mellitus, Experimental; Disease Models, An	2008
Alloxan-induced diabetes delays repair in a rat model of closed tibial fracture. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:5 Topics: Alkaline Phosphatase; Alloxan; Animals; Bone Remodeling; Chondrogenesis; Diabetes Mellitus, Experime	2008
Metabolic and underlying causes of diabetes mellitus. Diabetes, 1982, Volume: 31, Issue:Suppl 1 Pt Topics: Alloxan; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Disease Models, Animal; D	1982
Complications of pregnancy and fetal development. Diabetes, 1982, Volume: 31, Issue:Suppl 1 Pt Topics: Alloxan; Animals; Congenital Abnormalities; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental;	1982
Indigenous microfloras and resistance to bacterial infection in mice with experimentally induced diabetes: a possible animal model for opportunistic infection. Canadian journal of microbiology, 1984, Volume: 30, Issue:2 Topics: Alloxan; Animals; Bacteria; Cecum; Diabetes Mellitus, Experimental; Disease Models, Animal; Enteroba	1984
Central and peripheral nervous system complications. Diabetes, 1982, Volume: 31, Issue:Suppl 1 Pt Topics: Alloxan; Animals; Central Nervous System Diseases; Cricetinae; Cricetulus; Diabetic Neuropathies; Di	1982
Animal models of diabetes. The American journal of medicine, 1981, Volume: 70, Issue:2 Topics: Alloxan; Animals; Cricetinae; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, An	1981
CFUs reduction and adaptation in mice with experimental diabetes. Experimental hematology, 1980, Volume: 8, Issue:2 Topics: Adaptation, Physiological; Alloxan; Animals; Bone Marrow Cells; Colony-Forming Units Assay; Diabetes	1980
The effects of alloxan diabetes on Yucatan miniature swine and their progeny. Metabolism: clinical and experimental, 1980, Volume: 29, Issue:1 Topics: Alloxan; Animals; Basement Membrane; Capillaries; Diabetes Mellitus, Experimental; Disease Models, A	1980
[Hyperlipoperoxidemia in mice induced by alloxan (author's transl)]. Rinsho byori. The Japanese journal of clinical pathology, 1981, Volume: 29, Issue:3 Topics: Alloxan; Animals; Disease Models, Animal; Lipid Peroxides; Male; Mice	1981
Gas exchange and respiratory mechanics in moderate and severe pulmonary oedema in dogs. Bulletin europeen de physiopathologie respiratoire, 1981, Volume: 17, Issue:2 Topics: Alloxan; Animals; Disease Models, Animal; Dogs; Lung; Lung Volume Measurements; Oleic Acids; Pulmona	1981
Streptozotocin and alloxan are comparable agents in the diabetic model of impaired wound healing. Diabetes research (Edinburgh, Scotland), 1993, Volume: 23, Issue:2 Topics: Alloxan; Analysis of Variance; Animals; Collagenases; Diabetes Mellitus, Experimental; Disease Model	1993
A novel model of cutaneous candidiasis produced in prednisolone-treated guinea-pigs. Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology, 1994, Volume: 32, Issue:5 Topics: Administration, Topical; Alloxan; Animals; Antifungal Agents; Candida albicans; Candidiasis, Cutaneo	1994
Corneal edema recovery dynamics in diabetes: is the alloxan induced diabetic rabbit a useful model? Investigative ophthalmology & visual science, 1994, Volume: 35, Issue:1 Topics: Adolescent; Adult; Alloxan; Animals; Contact Lenses, Hydrophilic; Cornea; Corneal Edema; Diabetes Me	1994
Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique. Laboratory animals, 1993, Volume: 27, Issue:3 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Gluc	1993
Inhibition of alloxan-induced hyperglycaemia in mice by the pyridoindole stobadine. Pharmacology & toxicology, 1995, Volume: 77, Issue:5 Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Carbolines; Disease Models, Animal; Dose-Response Rel	1995
[Experimental models in research of the pathomechanism of diabetes mellitus]. Orvosi hetilap, 1996, Aug-25, Volume: 137, Issue:34 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal	1996
Demonstration of two different processes of beta-cell regeneration in a new diabetic mouse model induced by selective perfusion of alloxan. Diabetes, 1997, Volume: 46, Issue:8 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus, Experimental; Diseas	1997
Toxin-induced IDDM (insulin dependent diabetes mellitus) in the musk shrew. Life sciences, 1998, Volume: 63, Issue:6 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease	1998
Vascular responsiveness in alloxan-induced diabetes-susceptible (ALS) and resistant (ALR) mice. The Journal of veterinary medical science, 1998, Volume: 60, Issue:10 Topics: Alloxan; Animals; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; Dinoprost; Disease Mod	1998
Upregulation of endothelin A receptor sites in the rabbit diabetic kidney: potential relevance to the early pathogenesis of diabetic nephropathy. Nephron, 1999, Volume: 83, Issue:3 Topics: Alloxan; Animals; Autoradiography; Azepines; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabet	1999
Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook. fruit powder in alloxan-diabetic rats. Journal of ethnopharmacology, 1999, Volume: 67, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Cholesterol; Cucurbitaceae; Diabetes Mellitus, Experimental; Diseas	1999
Hypoglycaemic activity of Ocimum gratissimum in rats. Fitoterapia, 2000, Volume: 71, Issue:4 Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models,	2000
Effects of known and potential antioxidants on animal models of pathological processes (diabetes, gastric lesions, allergic bronchospasm). Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2000, Volume: 52, Issue:5 Topics: Alloxan; Animals; Antioxidants; Bronchial Spasm; Diabetes Mellitus, Experimental; Disease Models, An	2000
Aortic atheromatous lesions developed in APA hamsters with streptozotocin induced diabetes: a new animal model for diabetic atherosclerosis. 1. Histopathological studies. Experimental animals, 2000, Volume: 49, Issue:4 Topics: Alloxan; Animals; Aortic Diseases; Arteriosclerosis; Cholesterol; Cholesterol, HDL; Cricetinae; Diab	2000
Protective action of arachidonic acid against alloxan-induced cytotoxicity and diabetes mellitus. Prostaglandins, leukotrienes, and essential fatty acids, 2001, Volume: 64, Issue:1 Topics: Alloxan; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Cell Survival; Diabetes Mellitus, Exper	2001
Protective effect of the antioxidant 6-ethoxy-2,2-pentamethylen-1,2-dihydroquinoline (S 33113) in models of cerebral neurodegeneration. European journal of pharmacology, 2001, Mar-23, Volume: 416, Issue:1-2 Topics: Alloxan; Animals; Antioxidants; Body Temperature; Brain Ischemia; Cell Survival; Cerebral Cortex; Co	2001
Administration of NF-kappaB decoy inhibits pancreatic activation of NF-kappaB and prevents diabetogenesis by alloxan in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:9 Topics: Alloxan; Animals; Apoptosis; Diabetes Mellitus, Experimental; Disease Models, Animal; Hyperglycemia;	2001
Inducible nitric oxide synthase in rat neutrophils: role of insulin. Biochemical pharmacology, 2001, Aug-01, Volume: 62, Issue:3 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Insulin; Male; Neutrophil	2001
Antidiabetic effect of Cogent db, a herbal drug in alloxan-induced diabetes mellitus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2002, Volume: 131, Issue:1 Topics: Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Anima	2002
Hypoglycemic and hypotriglyceridemic effects of tolbutamide in triphenyltin chloride-induced diabetic rabbits. Veterinary and human toxicology, 2002, Volume: 44, Issue:3 Topics: Administration, Oral; Alloxan; Animals; Blood Glucose; Diabetes Mellitus; Disease Models, Animal; Do	2002
Intestinal rather than hepatic microsomal triglyceride transfer protein as a cause of postprandial dyslipidemia in diabetes. Metabolism: clinical and experimental, 2002, Volume: 51, Issue:7 Topics: Alloxan; Animals; Apolipoprotein B-100; Apolipoprotein B-48; Apolipoproteins B; Carrier Proteins; Ch	2002
Studies on streptozotocin diabetes. Diabetes, 1976, Volume: 25, Issue:7 Topics: Alloxan; Animals; Blood Glucose; Deoxy Sugars; Deoxyglucose; Diabetes Mellitus; Diabetes Mellitus, E	1976
Failure of positive end-expiratory pressure to decrease lung water content in alloxan-induced pulmonary edema. The American review of respiratory disease, 1979, Volume: 120, Issue:4 Topics: Alloxan; Animals; Body Water; Disease Models, Animal; Dogs; Lung; Oxygen; Positive-Pressure Respirat	1979
Alloxan induced fatty liver degeneration in rat: its effect on the microsomal lipids. Experimental and molecular pathology, 1975, Volume: 22, Issue:1 Topics: Alloxan; Animals; Arachidonic Acids; Carbon Radioisotopes; Cell Fractionation; Cholesterol; Chromato	1975
An evaluation of the role of leukocytes in the pathogenesis of experimentally induced corneal vascularization. The American journal of pathology, 1975, Volume: 79, Issue:3 Topics: Administration, Topical; Alloxan; Animals; Antigen-Antibody Complex; Cattle; Cautery; Cornea; Cornea	1975
Pulmonary capillary permeability in man and a canine model of chemical pulmonary edema. Microvascular research, 1975, Volume: 10, Issue:2 Topics: Adult; Alloxan; Animals; Blood Flow Velocity; Blood Pressure; Blood Volume; Capillaries; Capillary P	1975
Effect of diabetes mellitus on epididymal enzymes of adult rats. Indian journal of experimental biology, 1991, Volume: 29, Issue:10 Topics: Acid Phosphatase; Adenosine Triphosphatases; Alkaline Phosphatase; Alloxan; Animals; Ca(2+) Mg(2+)-A	1991
Retinal polyol and myo-inositol in galactosemic dogs given an aldose-reductase inhibitor. Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:13 Topics: Aldehyde Reductase; Alloxan; Animals; Chromatography, Gas; Diabetes Mellitus, Experimental; Disease	1991
Rabbit aortic smooth muscle cell culture. A model for the pharmacological study of diabetes-induced alterations in cell proliferation. Journal of pharmacological methods, 1991, Volume: 26, Issue:3 Topics: Alloxan; Animals; Aorta, Thoracic; Cell Count; Cell Differentiation; Cell Division; Cells, Cultured;	1991
[Diabetic peculiarity of the ALS-Ay and ALR-Ay strains]. Jikken dobutsu. Experimental animals, 1991, Volume: 40, Issue:3 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose Tolerance	1991
The patency of the retinal vasculature to erythrocytes in retinal vascular disease. Investigative ophthalmology & visual science, 1990, Mar-01, Volume: 31, Issue:3 Topics: Alloxan; Animals; Diabetic Retinopathy; Disease Models, Animal; Endothelium, Vascular; Erythrocytes;	1990
Assessment of the diabetogenic drugs alloxan and streptozotocin as models for the study of immune defects in diabetic mice. Diabetologia, 1985, Volume: 28, Issue:10 Topics: Alloxan; Animals; Antibody Formation; B-Lymphocytes; Diabetes Mellitus, Experimental; Disease Models	1985
Alloxan-induced diabetes mellitus in pregnant sheep and chronic fetal catheterization. Laboratory animals, 1988, Volume: 22, Issue:1 Topics: Alloxan; Animals; Birth Weight; Blood Gas Analysis; Blood Glucose; Catheterization; Diabetes Mellitu	1988
Variations of susceptibility to alloxan induced diabetes in the rabbit. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1987, Volume: 19, Issue:11 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Disease Susceptibility; D	1987
The partially diabetic pancreas: a histological study of a new animal model. Pancreas, 1987, Volume: 2, Issue:1 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Tolerance Test; I	1987
Alloxan-induced hyperglycemia in rabbits and the response of platelets to aggregating agents in vitro and to exposed subendothelium in vivo. Thrombosis research, 1987, Jun-01, Volume: 46, Issue:5 Topics: Adenosine Diphosphate; Alloxan; Animals; Arteries; Blood Platelets; Cell Adhesion; Collagen; Diabete	1987
Streptozotocin diabetes. Correlation with extent of depression of pancreatic islet nicotinamide adenine dinucleotide. The Journal of clinical investigation, 1974, Volume: 54, Issue:3 Topics: Alloxan; Animals; Carbon Radioisotopes; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease	1974
Serial in vivo determination of motor conduction velocity in tails of allaxanized non-diabetic and diabetic rats. Journal of the neurological sciences, 1974, Volume: 22, Issue:2 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; El	1974
[Experimental study on the production of diabetic retinopathy. Preliminary report]. Nihon ganka kiyo, 1971, Volume: 22, Issue:9 Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Diet; Disease Models, Anima	1971
Experimental cutaneous Candida albicans infection in guinea-pigs. Sabouraudia, 1971, Volume: 9, Issue:1 Topics: Age Factors; Alloxan; Animals; Candida; Candidiasis, Cutaneous; Disease Models, Animal; Guinea Pigs;	1971

alloxan and Disease Models, Animal