alloxan has been researched along with Diabetic Glomerulosclerosis in 31 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Curcumol, a natural metabolite with a good safety-profile, showed results comparable with tramadol in reversing diabetes-induced tactile allodynia and hyperalgesia." | 7.83 | Phytotherapeutic activity of curcumol: Isolation, GC-MS identification, and assessing potentials against acute and subchronic hyperglycemia, tactile allodynia, and hyperalgesia. ( Omar, AG; Raafat, KM, 2016) |
| " In the current manuscript, we studied the effect of pyridoxamine (PM) on protein glycation, oxidative stress, interleukin-1α (IL-1α), IL-6, C-reactive protein (CRP), gene expression of tumour necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in relation to microalbuminuria and kidney functions in a model of alloxan-induced diabetic rats." | 7.79 | Pyridoxamine, an inhibitor of protein glycation, in relation to microalbuminuria and proinflammatory cytokines in experimental diabetic nephropathy. ( Elseweidy, MM; Elswefy, SE; Younis, NN; Zaghloul, MS, 2013) |
| "Diabetic nephropathy is one of the major microvascular complications of diabetes mellitus which ultimately gives rise to cardiovascular diseases." | 5.46 | Small Molecule Inhibiting Nuclear Factor-kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan-Induced Diabetic Nephropathy in Rat. ( Ahmed, S; Borgohain, MP; Choubey, A; Chowdhury, L; Kumar, S; Lahkar, M; Pant, R, 2017) |
| "Curcumol, a natural metabolite with a good safety-profile, showed results comparable with tramadol in reversing diabetes-induced tactile allodynia and hyperalgesia." | 3.83 | Phytotherapeutic activity of curcumol: Isolation, GC-MS identification, and assessing potentials against acute and subchronic hyperglycemia, tactile allodynia, and hyperalgesia. ( Omar, AG; Raafat, KM, 2016) |
| " Type 1 diabetes was induced in C57Bl/6, NMRI, BALB/c, and 129Sv mice by alloxan, and conscious glomerular filtration rate, proteinuria, and oxidative stress levels were measured in control and diabetic animals at baseline and after 5 and 10 wk." | 3.80 | Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes. ( Fasching, A; Franzén, S; Friederich-Persson, M; Hansell, P; Nangaku, M; Palm, F, 2014) |
| " In the current manuscript, we studied the effect of pyridoxamine (PM) on protein glycation, oxidative stress, interleukin-1α (IL-1α), IL-6, C-reactive protein (CRP), gene expression of tumour necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in relation to microalbuminuria and kidney functions in a model of alloxan-induced diabetic rats." | 3.79 | Pyridoxamine, an inhibitor of protein glycation, in relation to microalbuminuria and proinflammatory cytokines in experimental diabetic nephropathy. ( Elseweidy, MM; Elswefy, SE; Younis, NN; Zaghloul, MS, 2013) |
| "To explore the possible relevance of endothelial nitric oxide synthase (eNOS) in the pathophysiology of erectile dysfunction (ED) associated with diabetes mellitus, we compared the catalytic activity, protein expression, and cellular localization of eNOS with those of neuronal nitric oxide synthase (nNOS) in the penis of rats with alloxan-induced diabetes." | 3.71 | Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat. ( Akingba, AG; Burnett, AL, 2001) |
| "Diabetic nephropathy is one of the major microvascular complications of diabetes mellitus which ultimately gives rise to cardiovascular diseases." | 1.46 | Small Molecule Inhibiting Nuclear Factor-kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan-Induced Diabetic Nephropathy in Rat. ( Ahmed, S; Borgohain, MP; Choubey, A; Chowdhury, L; Kumar, S; Lahkar, M; Pant, R, 2017) |
| "Diosmin treatment produces significant reduction in the blood glucose and plasma insulin level and increases the body weight when compared with diabetic rats." | 1.43 | Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy. ( Ahmed, A; Ahmed, S; Bolshette, N; Borgohain, M; Chowdhury, L; Kwatra, M; Lahkar, M; Mundhe, N, 2016) |
| "Diabetic nephropathy is a major cause of morbidity and mortality in diabetic patients." | 1.38 | Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats. ( Abd el-Latif, FF; Khalifa, M; Sayed, AA, 2012) |
| "Taurine was administered orally for 3 weeks (1% w/v in drinking water) either from the day on which alloxan was injected or after the onset of diabetes." | 1.38 | Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats. ( Das, J; Sil, PC, 2012) |
| "Alloxan-treated controls had similar results to age-matched controls." | 1.30 | Upregulation of endothelin A receptor sites in the rabbit diabetic kidney: potential relevance to the early pathogenesis of diabetic nephropathy. ( Dashwood, MR; Khan, MA; Mikhailidis, DP; Morgan, RJ; Mumtaz, FH; Thompson, CS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (9.68) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 2 (6.45) | 29.6817 |
| 2010's | 21 (67.74) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Balmer, LA | 1 |
| Whiting, R | 1 |
| Rudnicka, C | 1 |
| Gallo, LA | 1 |
| Jandeleit, KA | 1 |
| Chow, Y | 1 |
| Chow, Z | 1 |
| Richardson, KL | 1 |
| Forbes, JM | 1 |
| Morahan, G | 1 |
| Ganesan, D | 2 |
| Albert, A | 2 |
| Paul, E | 2 |
| Ananthapadmanabhan, K | 1 |
| Andiappan, R | 1 |
| Sadasivam, SG | 1 |
| Adewoye, EO | 1 |
| Oguntola, MA | 1 |
| Ige, AO | 1 |
| França-Silva, N | 1 |
| Reis, NG | 1 |
| Santos, PF | 1 |
| Balbi, APC | 1 |
| Gargouri, M | 1 |
| Hamed, H | 1 |
| Akrouti, A | 1 |
| Dauvergne, X | 1 |
| Magné, C | 1 |
| El Feki, A | 1 |
| Holkar, A | 1 |
| Mariakuttikan, J | 1 |
| Sadasivam Selvam, G | 1 |
| Wang, X | 1 |
| Qin, A | 1 |
| Xiao, F | 1 |
| Olatunji, OJ | 1 |
| Zhang, S | 1 |
| Pan, D | 1 |
| Han, W | 1 |
| Wang, D | 1 |
| Ni, Y | 1 |
| Bhatti, R | 1 |
| Sharma, S | 1 |
| Singh, J | 1 |
| Singh, A | 1 |
| Ishar, MP | 1 |
| Elseweidy, MM | 1 |
| Elswefy, SE | 1 |
| Younis, NN | 1 |
| Zaghloul, MS | 1 |
| Franzén, S | 1 |
| Friederich-Persson, M | 1 |
| Fasching, A | 1 |
| Hansell, P | 1 |
| Nangaku, M | 1 |
| Palm, F | 1 |
| Qi, MY | 1 |
| Yang, JJ | 1 |
| Zhou, B | 1 |
| Pan, DY | 1 |
| Sun, X | 1 |
| Pinto, IF | 1 |
| Silva, RP | 1 |
| Chaves Filho, Ade B | 1 |
| Dantas, LS | 1 |
| Bispo, VS | 1 |
| Matos, IA | 1 |
| Otsuka, FA | 1 |
| Santos, AC | 1 |
| Matos, HR | 1 |
| Raafat, KM | 1 |
| Omar, AG | 1 |
| Yuan, YL | 1 |
| Guo, CR | 1 |
| Cui, LL | 1 |
| Ruan, SX | 1 |
| Zhang, CF | 1 |
| Ji, D | 1 |
| Yang, ZL | 1 |
| Li, F | 1 |
| Zhao, Q | 1 |
| Li, J | 1 |
| Yan, J | 1 |
| Liu, S | 1 |
| Guo, Y | 1 |
| Chen, D | 1 |
| Luo, Q | 1 |
| Ahmed, S | 2 |
| Mundhe, N | 1 |
| Borgohain, M | 1 |
| Chowdhury, L | 2 |
| Kwatra, M | 1 |
| Bolshette, N | 1 |
| Ahmed, A | 1 |
| Lahkar, M | 2 |
| Borgohain, MP | 1 |
| Kumar, S | 1 |
| Pant, R | 1 |
| Choubey, A | 1 |
| Mir, SH | 1 |
| Darzi, MM | 1 |
| Soto, C | 1 |
| Pérez, J | 1 |
| García, V | 1 |
| Uría, E | 1 |
| Vadillo, M | 1 |
| Raya, L | 1 |
| Sayed, AA | 1 |
| Khalifa, M | 1 |
| Abd el-Latif, FF | 1 |
| Lachin, T | 1 |
| Reza, H | 1 |
| Das, J | 1 |
| Sil, PC | 1 |
| Oršolić, N | 1 |
| Sirovina, D | 1 |
| Končić, MZ | 1 |
| Lacković, G | 1 |
| Gregorović, G | 1 |
| Janle-Swain, E | 1 |
| Thornhill, JA | 1 |
| Carter, JM | 1 |
| Hinsman, E | 1 |
| Jackson, HD | 1 |
| Ash, SR | 1 |
| Merikanto, J | 1 |
| Hietala, SO | 1 |
| Lithner, F | 1 |
| Hägg, E | 1 |
| Päivänsalo, M | 1 |
| Spadella, CT | 1 |
| Schellini, SA | 1 |
| Bacchi, CE | 1 |
| Khan, MA | 1 |
| Dashwood, MR | 1 |
| Mumtaz, FH | 1 |
| Thompson, CS | 1 |
| Mikhailidis, DP | 1 |
| Morgan, RJ | 1 |
| Akingba, AG | 1 |
| Burnett, AL | 1 |
| Matas, AJ | 1 |
| Sutherland, DE | 1 |
| Steffes, MW | 1 |
| Najarian, JS | 1 |
| Klin, M | 1 |
| Christlieb, AR | 1 |
3 reviews available for alloxan and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Islet transplantation.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mellitus; Diabetes M | 1977 |
[Mechanisms of compensatory hypertrophy of the kidney].
Topics: Acute Kidney Injury; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Huma | 1990 |
Diabetes and hypertensive vascular disease. Mechanisms and treatment.
Topics: Alloxan; Angiotensin II; Animals; Blood Volume; Diabetes Complications; Diabetes Mellitus; Diabetes | 1973 |
28 other studies available for alloxan and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Genetic characterization of early renal changes in a novel mouse model of diabetic kidney disease.
Topics: Aldehyde Reductase; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disea | 2019 |
Rutin ameliorates metabolic acidosis and fibrosis in alloxan induced diabetic nephropathy and cardiomyopathy in experimental rats.
Topics: Acidosis; Alloxan; Animals; Antioxidants; Blood Glucose; Cardiomyopathies; Diabetes Mellitus, Experi | 2020 |
Anti-oxidative and reno-restorative effects of physalis angulata (whole plant extract) in alloxan-induced diabetic male Wistar rats.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathi | 2016 |
Diabetes and pregnancy in Wistar rats: renal effects for mothers in the postpartum period.
Topics: Alloxan; Animals; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease M | 2018 |
Effects of Spirulina platensis on lipid peroxidation, antioxidant defenses, and tissue damage in kidney of alloxan-induced diabetic rats.
Topics: Alloxan; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Blood Gluco | 2018 |
Combination of ramipril and rutin alleviate alloxan induced diabetic nephropathy targeting multiple stress pathways in vivo.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination | 2018 |
N
Topics: Adenosine; Alloxan; Animals; Blood Glucose; Cordyceps; Creatinine; Cytokines; Diabetic Nephropathies | 2019 |
Effect of Aegle marmelos (L.) Correa on alloxan induced early stage diabetic nephropathy in rats.
Topics: Aegle; Alloxan; Animals; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diabetic Nephropa | 2013 |
Pyridoxamine, an inhibitor of protein glycation, in relation to microalbuminuria and proinflammatory cytokines in experimental diabetic nephropathy.
Topics: Albuminuria; Alloxan; Animals; C-Reactive Protein; Cytokines; Diabetes Mellitus, Experimental; Diabe | 2013 |
Differences in susceptibility to develop parameters of diabetic nephropathy in four mouse strains with type 1 diabetes.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies | 2014 |
[Study on the protective effect of ursolic acid on alloxan-induced diabetic renal injury and its underlying mechanisms].
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, E | 2014 |
Study of Antiglycation, Hypoglycemic, and Nephroprotective Activities of the Green Dwarf Variety Coconut Water (Cocos nucifera L.) in Alloxan-Induced Diabetic Rats.
Topics: Acarbose; Alloxan; Animals; Antioxidants; Beverages; Caffeic Acids; Cocos; Diabetes Mellitus, Experi | 2015 |
Phytotherapeutic activity of curcumol: Isolation, GC-MS identification, and assessing potentials against acute and subchronic hyperglycemia, tactile allodynia, and hyperalgesia.
Topics: Alloxan; Analgesics; Animals; Antioxidants; Biomarkers; Blood Glucose; Curcuma; Diabetes Mellitus, E | 2016 |
Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-κB signaling pathways in alloxan-induced mice.
Topics: Alloxan; Anemarrhena; Animals; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Dia | 2015 |
Lycium barbarum polysaccharides ameliorates renal injury and inflammatory reaction in alloxan-induced diabetic nephropathy rabbits.
Topics: Alloxan; Animals; Blood Glucose; Body Weight; Chemokine CCL2; Diabetic Nephropathies; Inflammation; | 2016 |
Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy.
Topics: Alloxan; Animals; Cytokines; Diabetic Nephropathies; Diosmin; Down-Regulation; Hyperglycemia; Hypogl | 2016 |
Small Molecule Inhibiting Nuclear Factor-kB Ameliorates Oxidative Stress and Suppresses Renal Inflammation in Early Stage of Alloxan-Induced Diabetic Nephropathy in Rat.
Topics: Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dose-Respon | 2017 |
Histopathological abnormalities of prolonged alloxan-induced diabetes mellitus in rabbits.
Topics: Alloxan; Animals; Blood Glucose; Brain Diseases; Diabetes Mellitus, Experimental; Diabetic Nephropat | 2009 |
Effect of silymarin on kidneys of rats suffering from alloxan-induced diabetes mellitus.
Topics: Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Mal | 2010 |
Fenugreek attenuation of diabetic nephropathy in alloxan-diabetic rats: attenuation of diabetic nephropathy in rats.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Antioxidants; Catalase; Diabetes Mellitus, Experimental; | 2012 |
Anti diabetic effect of cherries in alloxan induced diabetic rats.
Topics: Administration, Oral; Albuminuria; Alloxan; Animals; Biomarkers; Blood Glucose; Creatinine; Diabetes | 2012 |
Taurine ameliorates alloxan-induced diabetic renal injury, oxidative stress-related signaling pathways and apoptosis in rats.
Topics: Administration, Oral; Albumins; Alloxan; Animals; Antioxidants; Apoptosis; Blood Glucose; Blood Urea | 2012 |
Effect of Croatian propolis on diabetic nephropathy and liver toxicity in mice.
Topics: Alloxan; Animals; Antioxidants; Croatia; Diabetic Nephropathies; Female; Humans; Kidney; Lipid Perox | 2012 |
Case study of a diabetic dog with chronic membranous glomerulopathy treated with continuous intraperitoneal insulin infusion.
Topics: Alloxan; Animals; Catheters, Indwelling; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Do | 1982 |
Microangiography--a sensitive method for studying experimental diabetic nephropathy.
Topics: Alloxan; Angiography; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; Male | 1993 |
Pancreas transplantation versus islet transplantation versus insulin therapy in the prevention of nephropathy in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Graft Survival; Insulin; | 1998 |
Upregulation of endothelin A receptor sites in the rabbit diabetic kidney: potential relevance to the early pathogenesis of diabetic nephropathy.
Topics: Alloxan; Animals; Autoradiography; Azepines; Blood Glucose; Blood Urea Nitrogen; Body Weight; Diabet | 1999 |
Endothelial nitric oxide synthase protein expression, localization, and activity in the penis of the alloxan-induced diabetic rat.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Erectile Dysfunction; Imm | 2001 |