alloxan has been researched along with Diabetes Mellitus, Type 2 in 38 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "From this study, we conclude that quercetin ameliorates hyperglycemia and oxidative stress, by blunting free radical induced toxicity in T2DM." | 7.80 | Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. ( Alam, MM; Meerza, D; Naseem, I, 2014) |
| " The current study investigates protection against the hyperglycemia and dyslipidemia in alloxan-induced (type I diabetes) and fructose-fed insulin resistance (type II diabetes) models of diabetes treated with aqueous methanolic root extract of E." | 3.91 | Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes. ( Akram, A; Aslam, N; Chaudhry, SRY; Iqbal, Z; Jabeen, Q; Muhammad, S; Nazir, I; Wajid, M, 2019) |
| "From this study, we conclude that quercetin ameliorates hyperglycemia and oxidative stress, by blunting free radical induced toxicity in T2DM." | 3.80 | Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice. ( Alam, MM; Meerza, D; Naseem, I, 2014) |
| "At 28 days, the alloxan animals exhibited higher insulin resistance as measured by the disappearance of glucose serum (% Kitt/min) during the ITT." | 3.78 | Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan. ( Botezelli, JD; Cambri, LT; da Silva Sponton, AC; Dalia, RA; de Araújo, MB; de Mello, MA; Ribeiro, C, 2012) |
| "Type 2 diabetes is more prevalent (90-95%) in adults than type 1." | 2.82 | Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review. ( Ahmad, R; Bari, DG; Gaur, R; Gautam, GK; Parveen, K; Rais, N; Shukla, KS; Singh, AP; Ved, A, 2022) |
| " Both DMIS and DMIA models have served as key experimental tools to evaluate and understand the pharmacokinetic disposition of scores of drugs and therefore some key questions with respect to absorption, metabolism or elimination of drugs can be answered during the development of full-blown diabetes in the animal models." | 2.52 | Strategies for preclinical pharmacokinetic investigation in streptozotocin-induced diabetes mellitus (DMIS) and alloxan-induced diabetes mellitus (DMIA) rat models: case studies and perspectives. ( Srinivas, NR, 2015) |
| "Arachidonic acid (AA) has potent anti-inflammatory actions and prevents the cytotoxic actions of alloxan and streptozotocin (STZ) against pancreatic β cells and thus, prevents the development of type 1 diabetes mellitus (induced by alloxan and STZ) and by virtue of its anti-inflammatory actions protects against the development of type 2 diabetes mellitus (DM) induced by STZ in experimental animals that are models of type 1 and type 2 DM in humans." | 1.72 | Syntaxin interacts with arachidonic acid to prevent diabetes mellitus. ( Das, UN, 2022) |
| " Here, the toxic effects of dialuric acid targeting MAPT through in silico computational predictions have been investigated." | 1.62 | A system-level approach to investigate alloxan-induced toxicity in microtubule-binding protein to lead type 2 diabetes mellitus. ( Kannan, ND; Sathish Kumar, P, 2021) |
| "STZ (65 mg/kg)-induced type 2 diabetes mellitus animals showed reduced plasma BDNF and LXA4 levels (P < 0." | 1.51 | PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo. ( Bathina, S; Das, UN, 2019) |
| "Here metformin was delivered to diabetic mice and has got significant anti-diabetic effect can be considered as a kind of patch for NIDDM just like wearing and taking off a hand watch because hypoglycaemia can be removed by just taking off the patch." | 1.42 | A therapeutic TDS patch of Metformin from a HPMC-PVA blend studied with a biological membrane of fish-swim bladder: An approach for dermal application in NIDDM. ( Ferdaus, R; Jahan, L; Shaheen, SM, 2015) |
| "Impaired vasodilation in type 1 diabetes correlates with enhanced VSM MLC phosphorylation." | 1.35 | Impaired coronary microvascular dilation correlates with enhanced vascular smooth muscle MLC phosphorylation in diabetes. ( Bianchi, C; Boodhwani, M; Clements, RT; Feng, J; Khabbaz, KR; Liu, Y; Mieno, S; Sellke, FW; Sodha, NR, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.89) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 3 (7.89) | 29.6817 |
| 2010's | 17 (44.74) | 24.3611 |
| 2020's | 11 (28.95) | 2.80 |
| Authors | Studies |
|---|---|
| Rais, N | 1 |
| Ved, A | 1 |
| Ahmad, R | 1 |
| Parveen, K | 1 |
| Gautam, GK | 1 |
| Bari, DG | 1 |
| Shukla, KS | 1 |
| Gaur, R | 1 |
| Singh, AP | 1 |
| Park, YM | 1 |
| Noh, EM | 1 |
| Lee, HY | 1 |
| Shin, DY | 1 |
| Lee, YH | 1 |
| Kang, YG | 1 |
| Na, EJ | 1 |
| Kim, JH | 1 |
| Yang, HJ | 1 |
| Kim, MJ | 1 |
| Kim, KS | 1 |
| Bae, JS | 1 |
| Lee, YR | 1 |
| Das, UN | 2 |
| Guru, A | 1 |
| Sudhakaran, G | 1 |
| Almutairi, MH | 1 |
| Almutairi, BO | 1 |
| Juliet, A | 1 |
| Arockiaraj, J | 1 |
| Chaves, ADS | 3 |
| Magalhães, NS | 3 |
| Insuela, DBR | 3 |
| Silva, PMRE | 3 |
| Martins, MA | 3 |
| Carvalho, VF | 3 |
| Al-Shaeli, SJJ | 2 |
| Ethaeb, AM | 1 |
| Al-Zaidi, EAN | 1 |
| Al-Sarray, RAH | 1 |
| Bathina, S | 1 |
| Sajid, M | 1 |
| Khan, MR | 1 |
| Ismail, H | 1 |
| Latif, S | 1 |
| Rahim, AA | 1 |
| Mehboob, R | 1 |
| Shah, SA | 1 |
| Nasreen, W | 1 |
| Sarker, S | 1 |
| Sufian, MA | 1 |
| Md Opo, FAD | 1 |
| Shahriar, M | 1 |
| Akhter, R | 1 |
| Halim, MA | 1 |
| Sathish Kumar, P | 1 |
| Kannan, ND | 1 |
| Liu, Y | 2 |
| Deng, J | 1 |
| Fan, D | 1 |
| Ilić, V | 1 |
| Vukmirović, S | 1 |
| Stilinović, N | 1 |
| Čapo, I | 1 |
| Arsenović, M | 1 |
| Milijašević, B | 1 |
| Xu, M | 1 |
| Sun, B | 1 |
| Li, D | 1 |
| Mao, R | 1 |
| Li, H | 1 |
| Li, Y | 1 |
| Wang, J | 1 |
| Chaudhry, SR | 1 |
| Akram, A | 2 |
| Aslam, N | 2 |
| Asif, M | 1 |
| Wajid, M | 2 |
| Kinfe, T | 1 |
| Jabeen, Q | 2 |
| Muhammad, S | 2 |
| Abdullah, KM | 1 |
| Alam, MM | 2 |
| Iqbal, Z | 2 |
| Naseem, I | 2 |
| Rehman, K | 1 |
| Chohan, TA | 1 |
| Waheed, I | 1 |
| Gilani, Z | 1 |
| Akash, MSH | 1 |
| Chaudhry, SRY | 1 |
| Nazir, I | 1 |
| Sathya, A | 1 |
| Siddhuraju, P | 1 |
| Srinivas, NR | 1 |
| Meerza, D | 1 |
| Horiuchi, H | 1 |
| Harada, N | 1 |
| Adachi, T | 1 |
| Nakano, Y | 1 |
| Inui, H | 1 |
| Yamaji, R | 1 |
| Shaheen, SM | 1 |
| Jahan, L | 1 |
| Ferdaus, R | 1 |
| Vattam, KK | 1 |
| Raghavendran, H | 1 |
| Murali, MR | 1 |
| Savatey, H | 1 |
| Kamarul, T | 1 |
| Clements, RT | 1 |
| Sodha, NR | 1 |
| Feng, J | 1 |
| Boodhwani, M | 1 |
| Mieno, S | 1 |
| Khabbaz, KR | 1 |
| Bianchi, C | 1 |
| Sellke, FW | 1 |
| Aragão, DM | 1 |
| Guarize, L | 1 |
| Lanini, J | 1 |
| da Costa, JC | 1 |
| Garcia, RM | 1 |
| Scio, E | 1 |
| Zhang, SX | 1 |
| Sun, H | 1 |
| Sun, WJ | 1 |
| Jiao, GZ | 1 |
| Wang, XJ | 1 |
| Islam, MS | 1 |
| Wilson, RD | 1 |
| Ribeiro, C | 1 |
| Cambri, LT | 1 |
| Dalia, RA | 1 |
| de Araújo, MB | 1 |
| Botezelli, JD | 1 |
| da Silva Sponton, AC | 1 |
| de Mello, MA | 1 |
| Syiem, D | 1 |
| Syngai, G | 1 |
| Khup, PZ | 1 |
| Khongwir, BS | 1 |
| Kharbuli, B | 1 |
| Kayang, H | 1 |
| Hinke, SA | 1 |
| Jansson, L | 1 |
| Eizirik, DL | 1 |
| Pipeleers, DG | 1 |
| Borg, LA | 1 |
| Hellerström, C | 1 |
| Andersson, A | 1 |
| Karasu, C | 1 |
| Altan, VM | 1 |
| Brand, CL | 1 |
| Jørgensen, PN | 1 |
| Svendsen, I | 1 |
| Holst, JJ | 1 |
| Goto, Y | 1 |
| Pipeleers, D | 1 |
| Tarui, S | 1 |
| Yamada, K | 1 |
| Hanafusa, T | 1 |
| Ni, YX | 1 |
4 reviews available for alloxan and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; NAD; Niacinami | 2022 |
Strategies for preclinical pharmacokinetic investigation in streptozotocin-induced diabetes mellitus (DMIS) and alloxan-induced diabetes mellitus (DMIA) rat models: case studies and perspectives.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Evaluation, Precl | 2015 |
Finding GAD: early detection of beta-cell injury.
Topics: Alloxan; Animals; Biomarkers; Cell Death; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glut | 2007 |
Purified islet cells in diabetes research.
Topics: Alloxan; Animals; Antigens, Surface; Cell Separation; Cells, Cultured; Cyclic AMP; Diabetes Mellitus | 1986 |
1 trial available for alloxan and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Metformin and Bee Venom: a Comparative Detection of Histological Alteration of the Pancreas and Systemic Inflammatory Markers in Diabetic Mice.
Topics: Alloxan; Animals; Bee Venoms; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
33 other studies available for alloxan and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Anti-diabetic effects of Protaetia brevitarsis in pancreatic islets and a murine diabetic model.
Topics: Alloxan; Animals; Biological Products; Blood Glucose; Coleoptera; Diabetes Mellitus, Experimental; D | 2021 |
Syntaxin interacts with arachidonic acid to prevent diabetes mellitus.
Topics: Alloxan; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Diabetes Mellitus, Type 2; Dinoproston | 2022 |
β-cells regeneration by WL15 of cysteine and glycine-rich protein 2 which reduces alloxan induced β-cell dysfunction and oxidative stress through phosphoenolpyruvate carboxykinase and insulin pathway in zebrafish in-vivo larval model.
Topics: Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Histone | 2022 |
Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor.
Topics: Alloxan; Animals; Captopril; Corticosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor.
Topics: Alloxan; Animals; Captopril; Corticosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor.
Topics: Alloxan; Animals; Captopril; Corticosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
Effect of the renin-angiotensin system on the exacerbation of adrenal glucocorticoid steroidogenesis in diabetic mice: Role of angiotensin-II type 2 receptor.
Topics: Alloxan; Animals; Captopril; Corticosterone; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2022 |
Serological and Histological Evaluation of the Effect of Honeybee Venom on Pancreas and Liver in Diabetic Mice.
Topics: Alloxan; Animals; Bee Venoms; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Experiment | 2022 |
PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo.
Topics: Alloxan; Animals; Arachidonic Acid; Benzo(a)pyrene; Brain-Derived Neurotrophic Factor; Cell Death; C | 2019 |
Antidiabetic and antioxidant potential of Alnus nitida leaves in alloxan induced diabetic rats.
Topics: Alloxan; Alnus; alpha-Amylases; alpha-Glucosidases; Animals; Antioxidants; Diabetes Mellitus, Experi | 2020 |
A possible alternative therapy for type 2 diabetes using Myristica fragrans Houtt in combination with glimepiride: in vivo evaluation and in silico support.
Topics: Alloxan; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Therapy, Combination; Fema | 2020 |
A system-level approach to investigate alloxan-induced toxicity in microtubule-binding protein to lead type 2 diabetes mellitus.
Topics: Alloxan; Animals; Barbiturates; Blood Proteins; Cell Membrane Permeability; Cytochrome P-450 Enzyme | 2021 |
G-Rh4 improves pancreatic β-cells dysfunction in vivo and in vitro by increased expression of Nrf2 and its target genes.
Topics: Alloxan; Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Knockd | 2021 |
Insight into anti-diabetic effect of low dose of stevioside.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diterpe | 2017 |
Beneficial Effects of Small Molecule Oligopeptides Isolated from Panax ginseng Meyer on Pancreatic Beta-Cell Dysfunction and Death in Diabetic Rats.
Topics: Alloxan; Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes | 2017 |
ANTIDIABETIC AND ANTIDYSLIPIDEMIC EFFECTS OF HELIOTROPIUM STRIGOSUM IN RAT MODELS OF TYPE I AND TYPE II DIABETES.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabete | 2016 |
Therapeutic effect of vitamin B
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2018 |
Taxifolin prevents postprandial hyperglycemia by regulating the activity of α-amylase: Evidence from an in vivo and in silico studies.
Topics: Acarbose; Alloxan; alpha-Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; B | 2019 |
Antidiabetic and antidyslipidemic potential of Echinops echinatus in rat models of type I and type II diabetes.
Topics: Alloxan; Animals; Body Weight; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2019 |
Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
Topics: Acacia; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Alloxan; Animals; Aspartate Amino | 2013 |
Protective effect of quercetin on hyperglycemia, oxidative stress and DNA damage in alloxan induced type 2 diabetic mice.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 2; DNA Damage; Glucose Transp | 2014 |
S-equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells.
Topics: Alloxan; Animals; Bacteria; Cell Death; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; | 2014 |
A therapeutic TDS patch of Metformin from a HPMC-PVA blend studied with a biological membrane of fish-swim bladder: An approach for dermal application in NIDDM.
Topics: Administration, Cutaneous; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2015 |
Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus.
Topics: Adiponectin; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2016 |
Impaired coronary microvascular dilation correlates with enhanced vascular smooth muscle MLC phosphorylation in diabetes.
Topics: Alloxan; Animals; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diab | 2009 |
Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Cecropia Plant; Diabetes Mellitus; Dia | 2010 |
Proteomic study of serum proteins in a type 2 diabetes mellitus rat model by Chinese traditional medicine Tianqi Jiangtang Capsule administration.
Topics: Alloxan; Animals; Blood Proteins; Capsules; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2010 |
Experimentally induced rodent models of type 2 diabetes.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fetal | 2012 |
Effects of physical training with different intensities of effort on lipid metabolism in rats submitted to the neonatal application of alloxan.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Energy | 2012 |
Hypoglycemic effects of Potentilla fulgens L in normal and alloxan-induced diabetic mice.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Re | 2002 |
Impairment of glucose-induced insulin secretion in human pancreatic islets transplanted to diabetic nude mice.
Topics: Adolescent; Adult; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glu | 1995 |
The role of the endothelium on enhanced contractile response of non-insulin-dependent diabetic rat aortae: effects of insulin treatment.
Topics: Adenosine Triphosphate; Alloxan; Animals; Aorta; Diabetes Mellitus, Type 2; Endothelium, Vascular; I | 1994 |
Evidence for a major role for glucagon in regulation of plasma glucose in conscious, nondiabetic, and alloxan-induced diabetic rabbits.
Topics: Alloxan; Animals; Antibodies, Monoclonal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes M | 1996 |
[Experimental animal models of diabetes mellitus].
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Typ | 1991 |
Animal models utilized in the research of diabetes mellitus--with special reference to insulitis-associated diabetes.
Topics: Alloxan; Animals; Chelating Agents; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diab | 1987 |
[Therapeutic effect of berberine on 60 patients with type II diabetes mellitus and experimental research].
Topics: Adult; Aged; Alloxan; Animals; Berberine; Berberine Alkaloids; Blood Glucose; Diabetes Mellitus, Exp | 1988 |