alloxan has been researched along with Chemical and Drug Induced Liver Injury in 15 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dietary supplementation with CM fruits effectively prevents the development of diabetes mellitus, dyslipidemia and hepatic inflammation in alloxan-induced diabetes." | 3.80 | Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats. ( Asgary, S; Najafi, S; Rafieian-Kopaei, M; Sahebkar, A; Shamsi, F, 2014) |
| "Ritonavir is an antiretroviral drug to treat HIV AIDS and inhibits cytochrome P450 3A4." | 1.43 | Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function. ( Goud, T; Maddi, S; Nayakanti, D; Thatipamula, RP, 2016) |
| "Platycodin D is a major pharmacological constituent of Platycodi Radix with immunomodulatory activity." | 1.42 | Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. ( Chen, T; Chen, Y; Gao, J; Ji, H; Ji, J; Lan, L; Wang, S; Wei, Y; Wu, H; Xiang, P; Xiao, W; Xie, P; Yan, T, 2015) |
| " However, an adverse effect induced by nano-TiO2 in many diseased conditions, typically characterized by oxidative stress (OS), remains unknown." | 1.40 | Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague-Dawley rats. ( Gao, W; Gou, X; Li, W; Liang, X; Lu, TJ; Qu, Z; Sha, B; Wang, S; Xu, F, 2014) |
| " These results indicate that alloxan is not selectively toxic to the pancreatic beta-cell and that sugars can protect against alloxan-induced cytotoxicity in hepatocytes." | 1.26 | Alloxan toxicity in isolated rat hepatocytes and protection by sugars. ( Fischer, LJ; Harman, AW, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aba, PE | 1 |
| Okorie-Kanu, CO | 1 |
| Abd Eldaim, MA | 1 |
| Shaban Abd Elrasoul, A | 1 |
| Abd Elaziz, SA | 1 |
| Sathya, A | 1 |
| Siddhuraju, P | 1 |
| Fan, W | 2 |
| Chen, K | 1 |
| Zheng, G | 2 |
| Wang, W | 2 |
| Teng, A | 2 |
| Liu, A | 2 |
| Ming, D | 1 |
| Yan, P | 1 |
| Sha, B | 1 |
| Gao, W | 1 |
| Wang, S | 2 |
| Gou, X | 1 |
| Li, W | 1 |
| Liang, X | 1 |
| Qu, Z | 1 |
| Xu, F | 1 |
| Lu, TJ | 1 |
| Asgary, S | 1 |
| Rafieian-Kopaei, M | 1 |
| Shamsi, F | 1 |
| Najafi, S | 1 |
| Sahebkar, A | 1 |
| Shah, NA | 1 |
| Khan, MR | 1 |
| Chen, T | 1 |
| Gao, J | 1 |
| Xiang, P | 1 |
| Chen, Y | 1 |
| Ji, J | 1 |
| Xie, P | 1 |
| Wu, H | 1 |
| Xiao, W | 1 |
| Wei, Y | 1 |
| Lan, L | 1 |
| Ji, H | 1 |
| Yan, T | 1 |
| Goud, T | 1 |
| Maddi, S | 1 |
| Nayakanti, D | 1 |
| Thatipamula, RP | 1 |
| Yang, J | 1 |
| Gao, M | 1 |
| Li, F | 1 |
| KATO, T | 1 |
| ISHIBE, T | 1 |
| HIRAYAMA, M | 1 |
| FUKUSHIGE, M | 1 |
| TAKENAKA, I | 1 |
| KAZUTA, M | 1 |
| Harman, AW | 1 |
| Fischer, LJ | 1 |
| Witzleben, CL | 1 |
| Kikuchi, Y | 1 |
| Hornung, G | 1 |
15 other studies available for alloxan and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Changes in some biochemical parameters of alloxanized rats administered with varying concentrations of quail egg solution.
Topics: Alloxan; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimenta | 2017 |
An aqueous extract from Moringa oleifera leaves ameliorates hepatotoxicity in alloxan-induced diabetic rats.
Topics: Alloxan; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experimen | 2017 |
Protective effect of bark and empty pod extracts from Acacia auriculiformis against paracetamol intoxicated liver injury and alloxan induced type II diabetes.
Topics: Acacia; Acetaminophen; Alanine Transaminase; Alkaline Phosphatase; Alloxan; Animals; Aspartate Amino | 2013 |
Role of liver fatty acid binding protein in hepatocellular injury: effect of CrPic treatment.
Topics: Alanine Transaminase; Alloxan; Animals; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, E | 2013 |
Oxidative stress increased hepatotoxicity induced by nano-titanium dioxide in BRL-3A cells and Sprague-Dawley rats.
Topics: Alloxan; Animals; Cell Culture Techniques; Cell Line; Cell Survival; Chemical and Drug Induced Liver | 2014 |
Biochemical and histopathological study of the anti-hyperglycemic and anti-hyperlipidemic effects of cornelian cherry (Cornus mas L.) in alloxan-induced diabetic rats.
Topics: Alkaline Phosphatase; Alloxan; Animals; Anthocyanins; Blood Glucose; Chemical and Drug Induced Liver | 2014 |
Antidiabetic effect of Sida cordata in alloxan induced diabetic rats.
Topics: Alloxan; Animals; Blood Glucose; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, Experime | 2014 |
Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance.
Topics: Alanine Transaminase; Alloxan; Animals; Aspartate Aminotransferases; Blood Glucose; Chemical and Dru | 2015 |
Altered pharmacokinetics and pharmacodynamics of repaglinide by ritonavir in rats with healthy, diabetic and impaired hepatic function.
Topics: Alloxan; Animals; Blood Glucose; Carbamates; Carbon Tetrachloride; Chemical and Drug Induced Liver I | 2016 |
Hepatoprotective activity of CrPic against alloxan-induced hepatotoxicity in mice.
Topics: Alloxan; Animals; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Malondialdehyde; Mice; | 2012 |
[Effects of Pedicularis decora extract on anti-oxidation injury in mice].
Topics: Alloxan; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Femal | 2002 |
BASIC STUDIES ON THE PROSTATE OF RAT UNDER VARIOUS HORMONAL ENVIRONMENT.
Topics: Alloxan; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cortisone; Estradio | 1965 |
Alloxan toxicity in isolated rat hepatocytes and protection by sugars.
Topics: Alloxan; Animals; Carbohydrates; Chemical and Drug Induced Liver Injury; Glucose; Glutathione; In Vi | 1982 |
The pathogenesis of iron hepatotoxicity.
Topics: Alloxan; Animals; Autoradiography; Blood Glucose; Chemical and Drug Induced Liver Injury; Ethionine; | 1969 |
[The tributyrin-splitting activity of liver and kidney in aminonucleoside and alloxan damaged rats after cholesterol and albumin loading].
Topics: Alloxan; Animals; Chemical and Drug Induced Liver Injury; Cholesterol; Fats; Glycerol; Kidney; Kidne | 1966 |