alloxan has been researched along with Cancer of Pancreas in 25 studies
Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In the present study, we studied the effect of various prostaglandins (PGs) on alloxan-induced cytotoxicity to rat insulinoma (RIN) cells." | 7.72 | Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. ( Das, UN; Devi, MM, 2004) |
| " In the present study the cytotoxic effects of (i) alloxan alone, (ii) a combination of alloxan and cysteine or (iii) hydrogen peroxide were investigated in two established insulinoma cell lines (HIT-T15 and RINm5F), and compared with the effects on J-774 cells." | 7.69 | Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress. ( Brunk, U; Ollinger, K; Zhang, H, 1995) |
| "In the present study, we studied the effect of various prostaglandins (PGs) on alloxan-induced cytotoxicity to rat insulinoma (RIN) cells." | 3.72 | Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro. ( Das, UN; Devi, MM, 2004) |
| " In the present study the cytotoxic effects of (i) alloxan alone, (ii) a combination of alloxan and cysteine or (iii) hydrogen peroxide were investigated in two established insulinoma cell lines (HIT-T15 and RINm5F), and compared with the effects on J-774 cells." | 3.69 | Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress. ( Brunk, U; Ollinger, K; Zhang, H, 1995) |
| " In the present study, we tested whether ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one), a glutathione peroxidase mimicking compound, could counteract the effects of IL-1 beta, H2O2 and alloxan in rat pancreatic islets and in the rat insulinoma cell line RINm5F (RIN cells)." | 3.69 | Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells. ( de-Mello, MA; Eizirik, DL; Flodström, M, 1996) |
| "STZ (65 mg/kg)-induced type 2 diabetes mellitus animals showed reduced plasma BDNF and LXA4 levels (P < 0." | 1.51 | PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo. ( Bathina, S; Das, UN, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (68.00) | 18.7374 |
| 1990's | 4 (16.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 1 (4.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bathina, S | 1 |
| Das, UN | 2 |
| FLINN, LB | 1 |
| MINNICK, E | 1 |
| GAY, DM | 1 |
| Picton, SF | 1 |
| McCluskey, JT | 1 |
| Flatt, PR | 4 |
| McClenaghan, NH | 1 |
| BOTTGER, H | 1 |
| ROMER, K | 1 |
| SEITZ, R | 1 |
| FISHER, J | 1 |
| GIUS, JA | 1 |
| JANES, RG | 1 |
| SHAMBLIN, JR | 1 |
| ZIMMER, FE | 1 |
| BECK, AM | 1 |
| KROOK, L | 1 |
| MELLINGHOFF, CH | 1 |
| Devi, MM | 1 |
| Okamoto, H | 2 |
| Kazumi, T | 1 |
| Yoshino, G | 1 |
| Baba, S | 1 |
| Kikkawa, R | 1 |
| Haneda, M | 1 |
| Hatanaka, I | 1 |
| Yasuda, H | 1 |
| Shigeta, Y | 1 |
| Okuno, Y | 1 |
| Wada, M | 1 |
| Pour, PM | 1 |
| Donnelly, K | 1 |
| Stepan, K | 1 |
| Zhang, H | 1 |
| Ollinger, K | 1 |
| Brunk, U | 1 |
| de-Mello, MA | 1 |
| Flodström, M | 1 |
| Eizirik, DL | 1 |
| Bloch, KO | 1 |
| Zemel, R | 1 |
| Bloch, OV | 1 |
| Grief, H | 1 |
| Vardi, P | 1 |
| Janjic, D | 1 |
| Wollheim, CB | 1 |
| Lenzen, S | 1 |
| Freytag, S | 1 |
| Panten, U | 1 |
| Bailey, CJ | 1 |
| Shibier, O | 1 |
| Ioannides, C | 1 |
| Swanston-Flatt, SK | 2 |
| Yamagami, T | 1 |
| Miwa, A | 1 |
| Takasawa, S | 1 |
| Yamamoto, H | 1 |
| Tan, KS | 1 |
| Marks, V | 1 |
| Meglasson, MD | 1 |
| Burch, PT | 1 |
| Berner, DK | 1 |
| Najafi, H | 1 |
| Matschinsky, FM | 1 |
| Sener, A | 1 |
| Malaisse, WJ | 1 |
| Wüstenberg, PW | 1 |
1 review available for alloxan and Cancer of Pancreas
| Article | Year |
|---|---|
[The hypoglycemia syndrome].
Topics: Alloxan; Angiography; Antibiotics, Antineoplastic; Blood Glucose; Diagnosis, Differential; Diazoxide | 1970 |
24 other studies available for alloxan and Cancer of Pancreas
| Article | Year |
|---|---|
PUFAs, BDNF and lipoxin A4 inhibit chemical-induced cytotoxicity of RIN5F cells in vitro and streptozotocin-induced type 2 diabetes mellitus in vivo.
Topics: Alloxan; Animals; Arachidonic Acid; Benzo(a)pyrene; Brain-Derived Neurotrophic Factor; Cell Death; C | 2019 |
Alloxan in the treatment of a case of islet cell carcinoma of the pancreas with liver metastases.
Topics: Alloxan; Carcinoma, Islet Cell; Humans; Liver Neoplasms; Pancreatic Neoplasms | 1947 |
Effects of cytotoxic agents on functional integrity and antioxidant enzymes in clonal beta-cells.
Topics: Alloxan; Animals; Apoptosis; Cell Line; Cytotoxins; Dose-Response Relationship, Drug; Hydrogen Perox | 2002 |
[Alloxan effects in islet cell tumor].
Topics: Adenoma, Islet Cell; Alloxan; Islands; Islets of Langerhans; Pancreatic Neoplasms | 1952 |
Islet-cell tumor of the pancreas with hyperinsulinism; failure of surgical and alloxan treatment; report of a case.
Topics: Adenoma, Islet Cell; Alloxan; Hyperinsulinism; Islands; Islets of Langerhans; Neoplasms; Pancreas; P | 1955 |
HYPERINSULINISM.
Topics: Adenoma; Adenoma, Islet Cell; Adrenal Cortex Hormones; Alloxan; Diagnosis, Differential; Diet; Diet | 1964 |
ISLET-CELL CARCINOMA TREATED WITH ALLOXAN; ASSOCIATED WITH CALCIFIED HEPATIC METASTASES AND THYROTOXIC MYOPATHY.
Topics: Adenoma, Islet Cell; Alloxan; Calcinosis; Drug Therapy; Humans; Hyperinsulinism; Hyperthyroidism; Hy | 1964 |
CANINE INSULOMA. TWO SURGICAL CASES WITH RELAPSES.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Dog Diseases; Dogs; Hypoglycemia; Insulinoma; Neoplasm Metast | 1965 |
[Alloxan and hyperinsulinism].
Topics: Alloxan; Humans; Hyperinsulinism; Pancreatic Neoplasms | 1952 |
Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro.
Topics: 6-Ketoprostaglandin F1 alpha; Alloxan; Alprostadil; Animals; Antioxidants; Apoptosis; Bucladesine; C | 2004 |
[Vasoactive intestinal polypeptide(VIP)- and insulin-producing cells--molecular biology, physiology and pathology].
Topics: Adenoma, Islet Cell; Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 1984 |
Pancreatic islet cell tumors found in rats given alloxan and nicotinamide.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Glycosuria; Islets of Langerhans; Male; Niacinamide; Pancreat | 1980 |
Insulin release from BK virus-induced and in vitro maintained insulinoma cells of Syrian golden hamster.
Topics: Adenoma, Islet Cell; Alloxan; Animals; BK Virus; Bucladesine; Cricetinae; Cyclic AMP; Insulin; Insul | 1983 |
Modification of pancreatic carcinogenesis in the hamster model. 3. Inhibitory effect of alloxan.
Topics: Alloxan; Animals; Blood Glucose; Cricetinae; Female; Gallbladder Neoplasms; Injections, Subcutaneous | 1983 |
Insulinoma cells in culture show pronounced sensitivity to alloxan-induced oxidative stress.
Topics: Alloxan; Animals; Cell Survival; Cricetinae; Cysteine; Dose-Response Relationship, Drug; Hydrogen Pe | 1995 |
Ebselen and cytokine-induced nitric oxide synthase expression in insulin-producing cells.
Topics: Alloxan; Animals; Antioxidants; Azoles; Cytokines; Humans; Hydrogen Peroxide; Insulin; Insulinoma; I | 1996 |
Streptozotocin and alloxan-based selection improves toxin resistance of insulin-producing RINm cells.
Topics: 3-O-Methylglucose; Alloxan; Analysis of Variance; Animals; Cell Division; Cell Survival; Drug Resist | 2000 |
Islet cell metabolism is reflected by the MTT (tetrazolium) colorimetric assay.
Topics: Alloxan; Animals; Cell Line; Cells, Cultured; Colorimetry; Glucose; Indicators and Reagents; Insulin | 1992 |
Alloxan and ninhydrin inhibition of hexokinase from pancreatic islets and tumoural insulin-secreting cells.
Topics: Alloxan; Animals; Dithiothreitol; Hexokinase; Indenes; Insulin; Insulin Secretion; Islets of Langerh | 1990 |
Studies on the chemical and immunological destruction of insulin-secreting islet cell tumours.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Blood Glucose; Cell Line; Insulin; Insulinoma; Male; Pancreat | 1989 |
Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors.
Topics: Adenoma, Islet Cell; Alloxan; Amides; Animals; Insulinoma; Male; NAD+ Nucleosidase; Niacinamide; Pan | 1985 |
Effects of cytotoxic drugs and inhibitors of insulin secretion on a serially transplantable rat insulinoma and cultured rat insulinoma cells.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Insuli | 1987 |
Identification of glucokinase as an alloxan-sensitive glucose sensor of the pancreatic beta-cell.
Topics: Alloxan; Animals; Glucokinase; In Vitro Techniques; Insulinoma; Islets of Langerhans; Kinetics; Live | 1986 |
Resistance to alloxan of tumoral insulin-producing cells.
Topics: Alloxan; Animals; Cell Line; Drug Resistance; Glucose; Insulin; Islets of Langerhans; Oxidation-Redu | 1985 |