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alloxan and Aging

alloxan has been researched along with Aging in 18 studies

Alloxan: Acidic compound formed by oxidation of URIC ACID. It is isolated as an efflorescent crystalline hydrate.
alloxan : A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the histological alterations of extracellular matrix in long-term alloxan-induced diabetes and aging urethras of male rats with descriptions of total connective tissue, muscle layer and collagen types I and III relative amounts."7.77Histologic study of urethral extracellular matrix and collagen from aging and long-term alloxan-induced diabetic male rats. ( Cassini, MF; Cologna, AJ; Fazan, VP; Foss, MC; Martins, AC; Reis, RB; Rodrigues, AA; Suaid, HJ; Tucci, S, 2011)
"to evaluate structural and functional effects of Alloxan- induced diabetes and aging on bladder of rats."7.74Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats. ( Cologna, AJ; Fazan, VP; Foss, MC; Martins, AC; Rodrigues, AA; Suaid, HJ; Tucci, S, 2008)
"Thus, alloxan diabetes increases ADA activity in an age- and tissue-specific manner."5.30Alloxan diabetes regulates adenosine deaminase activity in mice: tissue- and age-specific correlation. ( Sharma, R; Singh, LS, 1998)
"To evaluate the histological alterations of extracellular matrix in long-term alloxan-induced diabetes and aging urethras of male rats with descriptions of total connective tissue, muscle layer and collagen types I and III relative amounts."3.77Histologic study of urethral extracellular matrix and collagen from aging and long-term alloxan-induced diabetic male rats. ( Cassini, MF; Cologna, AJ; Fazan, VP; Foss, MC; Martins, AC; Reis, RB; Rodrigues, AA; Suaid, HJ; Tucci, S, 2011)
"to evaluate structural and functional effects of Alloxan- induced diabetes and aging on bladder of rats."3.74Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats. ( Cologna, AJ; Fazan, VP; Foss, MC; Martins, AC; Rodrigues, AA; Suaid, HJ; Tucci, S, 2008)
"Alloxan-induced hyperglycemia was accompanied by activation of lipid peroxidation processes with different degree of their completeness depending on the age of experimental animals."3.73Age-related differences in the degree of lipid peroxidation and state of antioxidant protection under the influence of alloxan. ( Gvozdenko, TA; Yan'kova, VI, 2005)
"Alloxan diabetes in lizards Calotes versicolor, belonging to three age groups, induced decreased levels of percentage of solubility of collagen in dorsal and ventral skin regions after 7 days of treatment."3.67Alloxan-induced changes in the collagen characteristics in the skin of male garden lizards, Calotes versicolor, from three age groups. ( Behera, HN; Mishra, G, 1986)
"Alloxan treatment reduced HSP90 levels and promoted proteasomal degradation of tau, c-Jun N-amino terminal kinase, and histone deacetylase (HDAC) 6."1.38Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes. ( Kimura, T; Maeda, S; Mizoroki, T; Murayama, M; Sahara, N; Soeda, Y; Takashima, A; Yamashita, S; Yoshiike, Y, 2012)
"Thus, alloxan diabetes increases ADA activity in an age- and tissue-specific manner."1.30Alloxan diabetes regulates adenosine deaminase activity in mice: tissue- and age-specific correlation. ( Sharma, R; Singh, LS, 1998)
"Both methylene blue and CoCl2 have been found to accelerate the ageing of collagen in normal lizards."1.28Effect of methylene blue and cobaltous chloride on the alloxan-induced changes in collagen characteristics in the skin of garden lizard Calotes versicolor. ( Behera, HN; Mishra, G, 1989)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-199011 (61.11)18.7374
1990's2 (11.11)18.2507
2000's2 (11.11)29.6817
2010's3 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kara, A1
Unal, D1
Simsek, N1
Yucel, A1
Yucel, N1
Selli, J1
Rodrigues, AA2
Suaid, HJ2
Tucci, S2
Fazan, VP2
Foss, MC2
Cologna, AJ2
Martins, AC2
Reis, RB1
Cassini, MF1
Yoshiike, Y1
Yamashita, S1
Mizoroki, T1
Maeda, S1
Murayama, M1
Kimura, T1
Sahara, N1
Soeda, Y1
Takashima, A1
MULLER, HK1
KLEIFELD, O1
FUCHS, R1
DARDENNE, U1
HOCKWIN, O1
ARENS, P1
SOKOLOVEROVA, IM1
Yan'kova, VI1
Gvozdenko, TA1
Riley, WJ1
McConnell, TJ1
Maclaren, NK1
McLaughlin, JV1
Taylor, G1
Altura, BM1
Lum, G1
Turlapaty, PD1
Altura, BT1
Kodama, T1
Iwase, M1
Nunoi, K1
Maki, Y1
Yoshinari, M1
Fujishima, M1
Singh, LS1
Sharma, R1
Mishra, G2
Behera, HN2
Broekhuyse, RM1
Rowsell, EV1
al-Tai, AH1
Carnie, JA1
Howland, BE1
Zebrowski, EJ1
Selye, H1
Tuchweber, B1
Gabbiani, G1
Finkelstein, JD1
Kyle, W1
Harris, BJ1

Other Studies

18 other studies available for alloxan and Aging

ArticleYear
Ultra-structural changes and apoptotic activity in cerebellum of post-menopausal-diabetic rats: a histochemical and ultra-structural study.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2014, Volume: 30, Issue:3

    Topics: Aging; Alloxan; Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain Edema; Cerebellum; Diabetes

2014
Long term evaluation of functional and morphological bladder alterations on alloxan-induced diabetes and aging: experimental study in rats.
    Acta cirurgica brasileira, 2008, Volume: 23 Suppl 1

    Topics: Aging; Alloxan; Animals; Collagen; Cystotomy; Denervation; Diabetes Mellitus, Experimental; Disease

2008
Histologic study of urethral extracellular matrix and collagen from aging and long-term alloxan-induced diabetic male rats.
    Urology, 2011, Volume: 77, Issue:2

    Topics: Aging; Alloxan; Animals; Collagen; Diabetes Mellitus, Experimental; Extracellular Matrix; Male; Rats

2011
Adaptive responses to alloxan-induced mild oxidative stress ameliorate certain tauopathy phenotypes.
    Aging cell, 2012, Volume: 11, Issue:1

    Topics: Acetylation; Adaptation, Physiological; Aging; Alloxan; Animals; Disease Models, Animal; Female; His

2012
[The breakdown of radiophosphorus into electrophoretically separable phosphate fractions by the lens, relative to age and to poisoning with naphthalene, dinitrophenol and alloxan].
    Albrecht von Graefe's Archiv fur Ophthalmologie, 1955, Volume: 156, Issue:5

    Topics: Aging; Alloxan; Animals; Cataract; Diabetes Mellitus, Experimental; Dinitrophenols; Lens, Crystallin

1955
[Role of the higher segments of the central nervous system, of the growth factor and of the sex hormones in the pathogenesis of experimental (alloxan) diabetes].
    Trudy - Institut fiziologii imeni I. P. Pavlova, 1959, Volume: 8

    Topics: Aging; Alloxan; Animals; Central Nervous System; Diabetes Mellitus, Experimental; Gonadal Steroid Ho

1959
Age-related differences in the degree of lipid peroxidation and state of antioxidant protection under the influence of alloxan.
    Bulletin of experimental biology and medicine, 2005, Volume: 139, Issue:3

    Topics: Aging; Alloxan; Animals; Antioxidants; Diabetes Mellitus, Experimental; Hyperglycemia; Hyperlipidemi

2005
The diabetogenic effects of streptozotocin in mice are prolonged and inversely related to age.
    Diabetes, 1981, Volume: 30, Issue:9

    Topics: Aging; Alloxan; Animals; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique; Glucose To

1981
Sequential changes in serum glucose, triglycerides and cholesterol in aging of normal and alloxan-diabetic rats.
    Experientia, 1981, Mar-15, Volume: 37, Issue:3

    Topics: Aging; Alloxan; Animals; Blood Glucose; Body Weight; Cholesterol; Creatinine; Diabetes Mellitus, Exp

1981
A new diabetes model induced by neonatal alloxan treatment in rats.
    Diabetes research and clinical practice, 1993, Volume: 20, Issue:3

    Topics: Acetylglucosaminidase; Aging; Alloxan; Animals; Animals, Newborn; Blood Glucose; Body Weight; Diabet

1993
Alloxan diabetes regulates adenosine deaminase activity in mice: tissue- and age-specific correlation.
    Biochemistry and molecular biology international, 1998, Volume: 46, Issue:1

    Topics: Adenosine Deaminase; Aging; Alloxan; Animals; Diabetes Mellitus, Experimental; Female; Intestine, Sm

1998
Effect of methylene blue and cobaltous chloride on the alloxan-induced changes in collagen characteristics in the skin of garden lizard Calotes versicolor.
    Archives of gerontology and geriatrics, 1989, Volume: 8, Issue:1

    Topics: Aging; Alloxan; Animals; Cobalt; Collagen; Drug Interactions; Lizards; Methylene Blue; Skin

1989
Alloxan-induced changes in the collagen characteristics in the skin of male garden lizards, Calotes versicolor, from three age groups.
    Archives of gerontology and geriatrics, 1986, Volume: 5, Issue:1

    Topics: Aging; Alloxan; Animals; Blood Glucose; Body Weight; Collagen; Diabetes Mellitus, Experimental; Live

1986
Lipids in tissues of the eye. V. Phospholipid metabolism in normal and cataractous lens.
    Biochimica et biophysica acta, 1971, Mar-16, Volume: 231, Issue:2

    Topics: Aging; Albumins; Alcohols; Alloxan; Animals; Cataract; Cattle; Cytosine Nucleotides; Diabetes Mellit

1971
Increased liver L-serine-pyruvate aminotransferase activity under gluconeogenic conditions.
    The Biochemical journal, 1973, Volume: 134, Issue:1

    Topics: Aging; Alloxan; Animals; Animals, Newborn; Female; Fetus; Glucagon; Gluconeogenesis; L-Serine Dehydr

1973
Serum and pituitary gonadotropin levels in alloxan-diabetic rats.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1974, Volume: 6, Issue:2

    Topics: Aging; Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dose-Response

1974
[Clinical implications of calciphylaxis].
    L'union medicale du Canada, 1969, Volume: 98, Issue:9

    Topics: Aged; Aging; Alloxan; Aluminum; Animals; Autonomic Nervous System; Calciphylaxis; Dextrans; Haplorhi

1969
Methionine metabolism in mammals. Regulation of homocysteine methyltransferases in rat tissue.
    Archives of biochemistry and biophysics, 1971, Volume: 146, Issue:1

    Topics: Aging; Alloxan; Animals; Betaine; Chromatography, Gel; Cycloheximide; Cysteine; Dactinomycin; Dietar

1971