allopurinol and Uterine-Neoplasms

Aminothiadiazole (NSC 4728) is an analog of the thiadiazoles, a group of drugs that stimulated interest because they do not cause significant myelosuppression and have a unique ability to increase uric acid production unrelated to tissue damage. Previous articles have reported results in ovarian cancer, squamous cell cervical cancer, nonsquamous cell cervical cancer, and endometrial cancer. The Gynecologic Oncology Group chose to study aminothiadiazole in patients with mixed mesodermal tumors of the uterus refractory to prior chemotherapy. Twenty-two patients were entered into this study. Eligibility required that patients had histologically confirmed measurable malignancy. All patients received a starting dose of aminothiadiazole of 125 mg/m2 intravenously (30-45 min infusion) repeated at weekly intervals. All patients also took allopurinol, 300 mg orally per day, to prevent hyperuricemia. Subsequent therapy was not given unless the white blood cell count was > 3,000/microliters and platelets were > 100,000/microliters prior to treatment. One patient (5%) in this study had a partial response, which lasted only 1.2 months. The site of this response was a mesenteric mass. Most patients in this study had no toxicity whatsoever, and no life-threatening toxicity was seen. There were no complete responses. Aminothiadiazole in this dose schedule appears to have no utility in previously treated patients with mixed mesodermal tumors of the uterus.

Topics: Adult; Aged; Aged, 80 and over; Allopurinol; Antineoplastic Agents; Drug Administration Schedule; Female; Gout Suppressants; Humans; Infusions, Intravenous; Middle Aged; Mixed Tumor, Mesodermal; Remission Induction; Thiadiazoles; Uric Acid; Uterine Neoplasms

The case of a 74-year-old female with an IgD kappa plasma cell leukemia is presented. In contrast to the majority of the cases in the literature, this patient responded rather well to melphalan and prednisolone and survived for 20 months after starting treatment. Another remarkable feature was the simultaneous occurrence of a double uterine neoplasm, a malignant mixed Müllerian tumor of the homologous variety (also called carcinosarcoma).

Topics: Adnexa Uteri; Aged; Allopurinol; Ampicillin; Carcinosarcoma; Female; Gentamicins; Humans; Hysterectomy; Immunoglobulin D; Immunoglobulin kappa-Chains; Leukemia, Plasma Cell; Melphalan; Pneumonia; Prednisolone; Uterine Neoplasms