allopurinol and Uterine-Cervical-Dysplasia

The aim of the study was to evaluate the activity of the pro- and antioxidant systems in cervical mucus of healthy women and women with pathological of disorders cervical. After cervical mucus liquefaction, the activity of superoxide dismutase, catalase and xanthine oxidase was determined by means of chemiluminescence assays. The activity of the antioxidant system in cervical mucus of healthy women was higher as compared to the group with pathological cervical disorders. Moreover, in mucus samples obtained from women with dysplasia, the significantly heightened activity of xanthine oxidase (strong pro-oxidant) was observed. The antioxidant system present in cervical mucus may protect both the cells of the uterine cervix and the viable sperm.

Topics: Adult; Case-Control Studies; Catalase; Cervix Mucus; Female; Free Radical Scavengers; Humans; Luminescent Measurements; Poland; Statistics, Nonparametric; Superoxide Dismutase; Uterine Cervical Dysplasia; Xanthine Oxidase