allopurinol and Urticaria

Topics: Aged; Alkaline Phosphatase; Allopurinol; Calcium; Colchicine; Humans; Male; Potassium; Sodium; Urticaria

Topics: Allopurinol; Ampicillin; Antibody Formation; Cross Reactions; Cytomegalovirus Infections; Drug Contamination; Drug Eruptions; Drug Synergism; Erythema; Humans; Immunity, Cellular; Infectious Mononucleosis; Leukemia, Lymphoid; Lymphocytes; Lymphoma, Large B-Cell, Diffuse; Urticaria

Cutaneous adverse drug reactions (CADRs) are drug-induced skin reactions with or without systemic involvement, ranging from mild maculopapular exanthema (MPE) to life-threatening severe CADRs (S-CADRs). Due to their unpredictability and severity, early recognition of suspected causative drugs is highly recommended. However, the profile of CADRs remains unknown in China.. To assess the clinical profile, predominant causative drugs, and cost associated with CADRs in Shanghai, China.. Clinical records of inpatients admitted with a diagnosis of CADRs to the dermatology ward of Huashan Hospital from January 2007 to December 2016 were retrospectively studied.. A total of 1,883 patients (1,231 female and 652 male), admitted with a diagnosis of CADR, were investigated. S-CADRs made up 21.99% of all cases (n=414), and urticaria (27.19%) was the most frequent reaction. Of the patients, 53.43% suffered from multiple drug-induced drug eruptions and the rest (45.83%) from single drug-induced drug eruptions. Overall, antimicrobials (28.85%) was the main drug group involved, and for S-CADRs, this was antiepileptic drugs (36.15%). The total cost for CADRs was RMB23,718,788.83 ($3,588,319.04). Both age and sex were related to admission cost (p=0.005 and p=7.84E. The management of CADRs requires considerable medical cost. CADRs are not only a health problem but also a significant financial burden for affected individuals.

Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Analgesics; Anti-Bacterial Agents; Anticonvulsants; Antipyretics; Child; China; Drug Eruptions; Drugs, Chinese Herbal; Female; Gout Suppressants; Health Care Costs; Hospitalization; Humans; Male; Middle Aged; Prognosis; Retrospective Studies; Sex Factors; Urticaria; Young Adult

Cutaneous adverse drug reactions (CADRs) are common skin adverse reactions associated with drugs.. To assess recent trends in CADRs and the drugs associated with them, using data from the past 5 years in the largest single database available on a hospital-based population in China.. All clinical records of inpatients admitted with a diagnosis of CADR to the Dermatology Ward, Huashan Hospital from January 2004 to December 2008 were retrospectively studied.. In the 734 patients, the three most common types of CADRs were nonsevere reactions, erythema multiforme (EM)-like eruptions (n = 255), urticaria (n = 192) and exanthematous reactions (n = 159), followed by three severe reactions: Stevens-Johnson syndrome (n = 58), toxic epidermal necrolysis (n = 29) and exfoliative dermatitis (n = 22). The most common single drug associated with the development of all drug eruptions was allopurinol, followed by amoxicillin, cephalosporins, antiepileptic agents and antipyretic/analgesic agents. However, the most common single drugs associated with severe reactions were antiepileptic agents, followed by allopurinol, antipyretic/analgesic agents and cephalosporins. In contrast to patients with nonsevere reactions, patients with severe reactions were more likely to be male (P < 0.001) and to have a greater mean age of onset (P < 0.001), a longer latency period (P < 0.001) and a longer duration of hospitalization (P < 0.001).. In contrast to previous studies, we found allopurinol to be the most common single drug associated with CADRs followed by antibiotics (amoxicillin and cephalosporins), and antiepileptic, especially carbamazepine. A higher incidence of EM-like eruptions and urticaria was also seen.

Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Allopurinol; Analgesics; Anti-Bacterial Agents; Anticonvulsants; Child; China; Drug Eruptions; Erythema Multiforme; Exanthema; Female; Gout Suppressants; Hospitalization; Humans; Length of Stay; Male; Middle Aged; Retrospective Studies; Sex Factors; Time Factors; Urticaria; Young Adult

Topics: Adult; Allopurinol; Angioedema; Desensitization, Immunologic; Drug Administration Schedule; Drug Eruptions; Gout; Gout Suppressants; Humans; Male; Uric Acid; Urticaria

Topics: Allopurinol; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Female; Humans; Middle Aged; Necrosis; Pruritus; Uric Acid; Urticaria