allopurinol and Testicular-Neoplasms

Although drug eruptions resembling graft-versus-host disease are rare, GvH-like reactions to the sulfhydryl group of drugs (penicillamine, captopril, gold sodium), phenobarbital and hepatitis vaccine have been described. Clinical reports concerning acute GvH-like drug rash are very uncommon and restricted to acetylsalicylic acid and spironolactone. We report on a patient who developed an acute GvH-like drug reaction caused by allopurinol. To our knowledge this variant of cytotoxic drug eruption has not yet been reported in literature.

Topics: Acute Disease; Adult; Allopurinol; Antimetabolites, Antineoplastic; Biopsy; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Eruptions; Graft vs Host Disease; Humans; Male; Neoplasm Staging; Skin; Testicular Neoplasms

Treatment of rats with a single carcinogenic dose of CdCl2 (i.e., 30 mumol/kg) caused severe hemorrhagic damage in the testis within the first 12 h after the metal. Subsequently, atrophy with calcification developed in the next 2-3 mo. Atrophied tissues regenerated during the 1 yr after exposure. Twelve hours after exposure to the Cd treatment, lipid peroxidation levels, Fe content, and cellular production of H2O2 were remarkably elevated in testicular Leydig cells, the target cell population for Cd carcinogenesis. At the same time, glutathione peroxidase activity rose, glutathione reductase and catalase activities were reduced, and superoxide dismutase activity was unchanged. Xanthine oxidase activity in Leydig cells was also elevated at 6 and 9 h after the Cd treatment. Reduced glutathione in testes was decreased and oxidized glutathione was increased 12 h after exposure to the metal. These facts suggest that the carcinogenic doses of Cd induced oxidative stress while compromising cellular defense mechanisms against such stress. Therefore, active oxygen species such as H2O2 may have an important role in the initiation of carcinogenesis within the target cell population.

Topics: Animals; Atrophy; Cadmium; Cadmium Chloride; Calcium; Cells, Cultured; Chlorides; Glutathione; Hemorrhage; Hydrogen Peroxide; Iron; Leydig Cells; Lipid Peroxidation; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Regeneration; Testicular Neoplasms; Testis; Xanthine Oxidase; Zinc

The paper discusses data on combined T-activin and cytostatic drug treatment of 9 cases of extensive cancer of the kidney and 9 cases of disseminated malignant tumor of the testicle. An immunomodulating effect of T-activin was shown.

Topics: Adjuvants, Immunologic; Allopurinol; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Fluorouracil; Humans; Kidney Neoplasms; Male; Peptides; Testicular Neoplasms; Thymus Extracts; Vinblastine

Topics: Allopurinol; Cyclophosphamide; Humans; Leukemia, Plasma Cell; Male; Middle Aged; Multiple Myeloma; Neoplasm Metastasis; Plasmapheresis; Prednisone; Recurrence; Skin Neoplasms; Testicular Neoplasms; Vincristine