allopurinol and Spondylitis--Ankylosing

Topics: Allopurinol; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Gold; Gout; Humans; Lupus Erythematosus, Systemic; Osteoarthritis; Penicillamine; Rheumatic Diseases; Salicylates; Spondylitis, Ankylosing; Vasculitis

Topics: Allopurinol; Arthritis; Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Immunoglobulin A; Immunoglobulin M; Male; Nails, Malformed; Prognosis; Psoriasis; Radiography; Spondylitis, Ankylosing

To assess the diagnosis of the activity of a pathological process in patients with ankylosing spondyloarthritis (AS) and to reveal purine metabolic (PM) changes in relation to the clinical features of AS.. The serum activities of the PM enzymes: xanthine oxidase (XO), guanine deaminase (GDA), guanosine deaminase (GSDA), purine nucleoside phosphorylase (PNP), guanosine phosphorylase (GP), and adenosine deaminase (ADA) were determined in 55 patients (51 males and 4 females) aged 36.0 +/- 1.4 years). A control group comprised 30 apparently age- and gender-matched healthy individuals, as in the study group.. On admission, the patients were found to have increased XO, GDA, PNP, and GD activities and decreased GSDA activity. The higher activity of the process was observed, the greater activities of GDA, XO, PNP, GP and the lower activity of GSDA and ADA were. There were the enzymatic activity differences that depended on the degree of pathological process activity, clinical form, the magnitude of X-ray changes, and the degree of joint functional insufficiency.. The findings suggest that there may be PM disturbances in the immunocompetent cells.

Topics: Adenosine Deaminase; Adult; Enzymes; Female; Guanine; Guanine Deaminase; Humans; Male; Nucleoside Deaminases; Predictive Value of Tests; Purine-Nucleoside Phosphorylase; Purines; Spondylitis, Ankylosing; Xanthine Oxidase

Topics: Allopurinol; Arthritis, Rheumatoid; Azathioprine; Blood Cells; Capsules; Clinical Trials as Topic; Eye Diseases; Female; Gastrointestinal Diseases; Gout; Humans; Indomethacin; Lupus Erythematosus, Systemic; Male; Middle Aged; Rheumatic Diseases; Scleroderma, Systemic; Spondylitis, Ankylosing; Suppositories

Nine phenolic compounds, catechin (1), epicatechin (2), gallocatechin (3), epigallocatechin (4), procyanidin B-4 (5), catechin-3-O-rhamnoside (6), rutin (7), querglanin (8) and isoquerglanin (9) were isolated from oak leaves (Quercus glauca Thunb. Fagaceae), and the latter two (8, 9) were identified as new compounds. Several Quercus species have been used in folk medicine as an astringent for hemorrhoids and for treatment of inflammation, jaundice, and tumor. In this study, these compounds were tested for scavenging effects of the superoxide anion in the whole blood of patients with ankylosing spondylitis by means of an ultra-sensitive chemoluminescence (CL) analyzer and lucigenin amplification. The results showed that at a concentration of 2.3 x 10(-5) M, isoquerglanin (9) displayed the strongest inhibition activity (73.55%), followed by querglanin (8) (68.81%) and then gallocatechin (3) and epigallocatechin (4) (66.97 and 60.17% inhibition, respectively). In addition, the blood chemoluminescence (CL) level of patients with ankylosing spondylitis was inhibited by superoxide dismutase (SOD) but not by catalase, suggesting that superoxide anion is the major component of reactive oxygen species (ROS) involved in this assay system.

Topics: Acridines; Catalase; Free Radical Scavengers; Gallic Acid; Glucosides; Glycosides; Humans; Luminescent Measurements; Spondylitis, Ankylosing; Superoxide Dismutase; Superoxides; Xanthine Oxidase

Topics: Allopurinol; Animals; Diet; Male; Ossification, Heterotopic; Oxonic Acid; Rats; Spondylitis, Ankylosing; Triazines; Urate Oxidase