allopurinol and Soft-Tissue-Neoplasms

Injection s.c. of purine 3-oxide into Wistar rats resulted in the appearance of sarcomas and fibromas at the interscapular site of administration, carcinomas in the liver, and a high incidence of s.c. fibromas in the hip at a distance from the site of injection. A small number of liver tumors but not tumors at the injection site appeared in rats to which the parent compound, purine, was administered. Oxidation of purine 3-oxide by xanthine oxidase was found to occur in two steps to yield the potent oncogen 3-hydroxyxanthine. A similar process may occur in vivo since a protein preparation from rat s.c. tissue has similar oxidizing activity.

Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Connective Tissue; Cyclic N-Oxides; Fibroma; Hypoxanthines; Injections, Subcutaneous; Liver Neoplasms; Male; Neoplasms, Experimental; Purines; Rats; Soft Tissue Neoplasms; Xanthine Oxidase

Topics: Allopurinol; Amputation Stumps; Arthroplasty; Hip Joint; Humans; Soft Tissue Neoplasms