allopurinol and Pneumonia--Viral

allopurinol has been researched along with Pneumonia--Viral* in 3 studies

Reviews

1 review(s) available for allopurinol and Pneumonia--Viral

ArticleYear
Uric Acid Elevation by Favipiravir, an Antiviral Drug.
    The Tohoku journal of experimental medicine, 2020, Volume: 251, Issue:2

    In light of the recent pandemic, favipiravir (Avigan

    Topics: Aldehyde Oxidase; Amides; Antiviral Agents; Biotransformation; Coronavirus Infections; COVID-19; Drug Interactions; Humans; Hyperuricemia; Kidney; Kidney Diseases; Molecular Structure; Organic Anion Transport Protein 1; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Pandemics; Pneumonia, Viral; Pyrazines; Uric Acid; Xanthine Oxidase

2020

Other Studies

2 other study(ies) available for allopurinol and Pneumonia--Viral

ArticleYear
Successful management of SARS-CoV-2 acute respiratory distress syndrome and newly diagnosed acute lymphoblastic leukemia.
    Blood advances, 2020, 09-22, Volume: 4, Issue:18

    Topics: Adolescent; Allopurinol; Anemia, Hemolytic, Autoimmune; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Betacoronavirus; Combined Modality Therapy; Coronavirus Infections; COVID-19; Cytokine Release Syndrome; Daunorubicin; Fluid Therapy; Humans; Male; Methylprednisolone; Nitriles; Pandemics; Pneumonia, Viral; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrimidines; Respiration, Artificial; Respiratory Distress Syndrome; SARS-CoV-2; Vincristine

2020
Pathogenesis of cytomegalovirus-associated pneumonitis in ICR mice: possible involvement of superoxide radicals.
    Archives of virology, 1992, Volume: 127, Issue:1-4

    We have studied the pathogenesis of murine cytomegalovirus (MCMV) pneumonitis in immunocompetent ICR mice and in mice treated with cyclophosphamide (CP). Intranasal infection of immunocompetent mice with MCMV resulted in transient and self-limited pulmonary lesions. When mice were given 200 mg/kg of CP one day before virus infection, transient splenic atrophy and subsequent splenic hypertrophy were induced, and the lesions in the lung were markedly augmented in their number and size although there was no significant enhancement of the virus growth. The augmentation coincided with the period of splenic hypertrophy. A marked increase in the number of pulmonary lesions was also induced in mice given 100 mg/kg of CP every 4 days following the initial dose of 200 mg/kg. In these mice, however, continuous splenic atrophy and augmented replication of MCMV in the lung were observed. When the activity of xanthine oxidase (XO) in lung tissue homogenates was measured, the activity was found to significantly increase after intranasal infection with MCMV irrespective of CP administration and there was a good correlation between the elevation of XO activity and the degree of pathological changes in the lung. In addition, we found that the administration of allopurinol, a specific inhibitor of XO and superoxide dismutase, a superoxide radical scavenger, reduced the number of the pulmonary lesions. These results suggest that superoxide radicals are involved in the pathogenesis of MCMV-associated pneumonitis in ICR mice.

    Topics: Allopurinol; Animals; Cytomegalovirus; Free Radicals; Lung; Male; Mice; Mice, Inbred ICR; Pneumonia, Viral; Superoxide Dismutase; Superoxides; Xanthine Oxidase

1992