allopurinol and Neuritis

allopurinol has been researched along with Neuritis* in 3 studies

Reviews

1 review(s) available for allopurinol and Neuritis

ArticleYear
[Syndrome of allopurinol hypersensitivity. Report of a new case and review of the Spanish literature].
    Medicina clinica, 1994, Feb-12, Volume: 102, Issue:5

    Allopurinol is a drug of wide clinical use and good tolerance. Some patients develop severe hypersensitivity due to immunologic reaction to the drug. A new case which fulfills all the diagnostic criteria of the syndrome of allopurinol hypersensitivity with associated clinical manifestations of multiple mononeuritis and evidence of granulomas and vasculitis in liver biopsy as the most significant data is reported. The syndrome was favorably resolved following withdrawal of the drug without need for corticoid therapy. The characteristics of the cases described in the Spanish literature over the last few years are globally reviewed. The absence of mortality is of note. The inconvenience of prescribing allopurinol to patients with asymptomatic hyperuricemia is emphasized.

    Topics: Aged; Allopurinol; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Granuloma; Humans; Liver Diseases; Male; Neuritis; Spain; Syndrome; Vasculitis

1994

Other Studies

2 other study(ies) available for allopurinol and Neuritis

ArticleYear
Oxidative stress and proinflammatory cytokines contribute to demyelination and axonal damage in a cerebellar culture model of neuroinflammation.
    PloS one, 2013, Volume: 8, Issue:2

    Demyelination and axonal damage are critical processes in the pathogenesis of multiple sclerosis (MS). Oxidative stress and pro-inflammatory cytokines elicited by inflammation mediates tissue damage.. To monitor the demyelination and axonal injury associated with microglia activation we employed a model using cerebellar organotypic cultures stimulated with lipopolysaccharide (LPS). Microglia activated by LPS released pro-inflammatory cytokines (IL-1β, IL-6 and TNFα), and increased the expression of inducible nitric oxide synthase (iNOS) and production of reactive oxygen species (ROS). This activation was associated with demyelination and axonal damage in cerebellar cultures. Axonal damage, as revealed by the presence of non-phosphorylated neurofilaments, mitochondrial accumulation in axonal spheroids, and axonal transection, was associated with stronger iNOS expression and concomitant increases in ROS. Moreover, we analyzed the contribution of pro-inflammatory cytokines and oxidative stress in demyelination and axonal degeneration using the iNOS inhibitor ethyl pyruvate, a free-scavenger and xanthine oxidase inhibitor allopurinol, as well as via blockage of pro-inflammatory cytokines using a Fc-TNFR1 construct. We found that blocking microglia activation with ethyl pyruvate or allopurinol significantly decreased axonal damage, and to a lesser extent, demyelination. Blocking TNFα significantly decreased demyelination but did not prevented axonal damage. Moreover, the most common therapy for MS, interferon-beta, was used as an example of an immunomodulator compound that can be tested in this model. In vitro, interferon-beta treatment decreased oxidative stress (iNOS and ROS levels) and the release of pro-inflammatory cytokines after LPS stimulation, reducing axonal damage.. The model of neuroinflammation using cerebellar culture stimulated with endotoxin mimicked myelin and axonal damage mediated by the combination of oxidative stress and pro-inflammatory cytokines. This model may both facilitate understanding of the events involved in neuroinflammation and aid in the development of neuroprotective therapies for the treatment of MS and other neurodegenerative diseases.

    Topics: Allopurinol; Animals; Axons; Cerebellum; Cytokines; Demyelinating Diseases; Free Radical Scavengers; Inflammation Mediators; Interferon-beta; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Myelin Sheath; Neuritis; Nitric Oxide Synthase Type II; Oligodendroglia; Oxidative Stress; Pyruvates; Tissue Culture Techniques; Tumor Necrosis Factor-alpha

2013
[Adverse effects of allopurinol].
    Zeitschrift fur arztliche Fortbildung, 1976, Oct-01, Volume: 70, Issue:19

    Topics: Allopurinol; Animals; Chemical and Drug Induced Liver Injury; Drug Eruptions; Gastrointestinal Diseases; Haplorhini; Hematologic Diseases; Humans; Kidney Diseases; Muscular Diseases; Neuritis

1976