allopurinol and Keratosis

Topics: Allopurinol; Antimetabolites; Collagen Diseases; Humans; Keratosis; Skin; Treatment Outcome

Perforating disorders represent a heterogenous group of dermatoses characterized by transepithelial elimination of dermal structures. Primary perforating disorders should be distinguished from secondary perforating disorders in which perforation with transepithelial elimination is a rare component of a variety of dermatoses. The primary perforating disorders are hyperkeratosis follicularis et parafollicularis in cutem penetrans (Kyrle's disease), elastosis perforans serpiginosa and perforating folliculitis. Acquired reactive perforating dermatosis (also known as acquired reactive perforating collagenosis) together with the hereditary variant of the reactive perforating collagenosis represent further examples of the primary perforating disorders. We report on 84 year old and 96 year old female patients with an acquired perforating dermatosis. Both of the patients additionally showed diabetes and hyperuricemia. Oral administration of allopurinol (100 mg daily) led to a healing of the disseminated skin lesions in 1-2 weeks. After a follow-up period of 6 months, both patients were in complete remission. On one hand, these results prove again the existence and the severity of this disease, and on the other hand suggest an immunomodulating or differentiation-promoting action in addition to the uricostatic effect of allopurinol.

Topics: Aged; Aged, 80 and over; Allopurinol; Antimetabolites; Antioxidants; Collagen Diseases; Female; Gout; Gout Suppressants; Humans; Keratosis; Skin; Skin Ulcer; Treatment Outcome

The metabolism of both free nucleosides and bases in hyperkeratosis induced by topical application of n-hexadecane on the epidermis of guinea pig was discussed, based on the technique of high-pressure liquid chromatography. The level of nucleosides and bases decreased in the hyperkeratotic stage of epidermis, in spite of the high concentration of nucleotides. The concentration of purine bases in the epidermis was under the virtual control of the salvage enzyme pathway and uric acid formation. The significant increase of salvage enzyme activity with phosphoribosylation was responsible for the expansion of the purine nucleotide pool in the hyperkeratotic epidermis. It was noted that the increased nucleotide pool plays a role as a source of cellular energy and a precursor of nucleic acid for epidermal proliferation.

Topics: Animals; Chromatography, High Pressure Liquid; Epidermis; Guinea Pigs; Keratosis; Nucleosides; Proteins; Purines; Pyrimidines; Uric Acid; Xanthine Oxidase

Topics: Adolescent; Adult; Allopurinol; Antineoplastic Agents; Azathioprine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyclophosphamide; Facial Neoplasms; Female; Hand; Humans; Immunosuppressive Agents; Keratoacanthoma; Keratosis; Kidney Transplantation; Leg; Lip Neoplasms; Male; Middle Aged; Nose Neoplasms; Postoperative Complications; Skin Neoplasms; Transplantation, Homologous