allopurinol and Hepatitis-A

Serum xanthine oxidase activity was measured by a radiochemical method in 137 consecutive patients with jaundice of varying etiology and in 40 non-jaundiced patients with liver or other disease. Serum xanthine oxidase was markedly increased, up to 50 times the upper normal limit (mean + 2 S.D.), in 32 out of 34 patients with infectious hepatitis. A slight elevation of serum xanthine oxidase, up to twice the upper normal limit, was found in 2 out of 49 patients with extrahepatic obstructive jaundice and in 4 out of 20 patients with chronic renal failure. In comparison to serum glutamic-oxaloacetic transaminase and lactate dehydrogenase serum xanthine oxidase appeared to be the more sensitive and specific indicator of acute hepatocellular damage.

Topics: Aspartate Aminotransferases; Chronic Disease; Hepatitis A; Humans; Jaundice; Kidney Failure, Chronic; L-Lactate Dehydrogenase; Liver Cirrhosis; Liver Neoplasms; Myocardial Infarction; Neoplasm Metastasis; Xanthine Oxidase

Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Chromatography, Gel; Female; Hemochromatosis; Hepatic Encephalopathy; Hepatitis; Hepatitis A; Humans; Intestinal Diseases; Liver Cirrhosis; Liver Diseases; Male; Myocardial Infarction; Rats; Spectrophotometry; Xanthine Oxidase

Topics: Aminohydrolases; Drug Stability; Erythrocytes; Fingers; Guanine; Hepatitis A; Humans; Kidney Diseases; Spectrophotometry; Uric Acid; Xanthine Oxidase

Topics: Alanine Transaminase; Aspartate Aminotransferases; Clinical Enzyme Tests; Diagnosis; Hepatitis; Hepatitis A; Humans; Jaundice; Jaundice, Obstructive; Liver Cirrhosis; Liver Diseases; Liver Function Tests; Myocardial Infarction; Statistics as Topic; Xanthine Oxidase

Topics: Blood Chemical Analysis; Carbon Isotopes; Chemistry Techniques, Analytical; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Ion Exchange Resins; Oxidation-Reduction; Uric Acid; Xanthine Oxidase

Topics: Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Cholestasis; Hepatitis A; Hepatitis, Animal; Humans; Liver Cirrhosis; Liver Diseases; Mice; Rats; Urate Oxidase; Xanthine Oxidase