allopurinol and Endomyocardial-Fibrosis

Adverse cardiac remodeling is a fundamental process in the progression to chronic heart failure. Although the mechanisms underlying cardiac remodeling are multi-factorial, a significant body of evidence points to the crucial roles of increased reactive oxygen species. This article reviews recent advances in delineating the different sources of production for reactive oxygen species (namely mitochondria, xanthine oxidase, uncoupled nitric oxide synthases, and NADPH oxidases) that may be involved in cardiac remodeling and the aspects of the remodeling process that they affect. These data could suggest new ways of targeting redox pathways for the prevention and treatment of adverse cardiac remodeling.

Topics: Animals; Endomyocardial Fibrosis; Heart Failure; Humans; Mitochondria, Heart; Myocardium; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; Ventricular Remodeling; Xanthine Oxidase