allopurinol and Communicable-Diseases

Oxidative stress plays a dual role in infections. Free radicals protect against invading microorganisms, and they can also cause tissue damage during the resulting inflammation. In the process of infection, there is generation of reactive species by myeloperoxidase, NADPH oxidase, and nitric oxide synthase. On the other hand, reactive species can be generated among others, by cytochrome P450, some metals, and xanthine oxidase. Some pathologies arising during infection can be attributed to oxidative stress and generation of reactive species in infection can even have fatal consequences. This article reviews the basic pathways in which reactive species can accumulate during infectious diseases and discusses the related health consequences.

Topics: Communicable Diseases; Cytochrome P-450 Enzyme System; Free Radicals; Humans; Metabolic Networks and Pathways; Metals; NADPH Oxidases; Nitric Oxide Synthase; Oxidative Stress; Peroxidase; Xanthine Oxidase

Topics: Blood Chemical Analysis; Carbon Isotopes; Chemistry Techniques, Analytical; Communicable Diseases; Hepatitis; Hepatitis A; Humans; Ion Exchange Resins; Oxidation-Reduction; Uric Acid; Xanthine Oxidase