allopurinol and Cholangitis--Sclerosing

allopurinol has been researched along with Cholangitis--Sclerosing* in 2 studies

Other Studies

2 other study(ies) available for allopurinol and Cholangitis--Sclerosing

ArticleYear
Allopurinol salvage therapy in pediatric overlap autoimmune hepatitis-primary sclerosing cholangitis with 6-MMP toxicity.
    Journal of pediatric gastroenterology and nutrition, 2010, Volume: 51, Issue:4

    Topics: Allopurinol; Antimetabolites; Child; Cholangitis, Sclerosing; Female; Follow-Up Studies; Hepatitis, Autoimmune; Humans; Male; Mercaptopurine; Salvage Therapy; Transaminases

2010
Xanthine oxidoreductase is present in bile ducts of normal and cirrhotic liver.
    Free radical biology & medicine, 2004, Oct-15, Volume: 37, Issue:8

    Xanthine oxidoreductase (XOR) is a widely distributed enzyme, involved in the metabolism of purines, which generates superoxide and is thought to be involved in free radical-generated tissue injury. It is present at high concentrations in the liver, from where it may be released during liver injury into the circulation, binding to vascular endothelium and causing vascular dysfunction. The cellular localization of the enzyme, essential to understanding its function, is, however, still debated. The present study has used a highly specific mouse monoclonal antibody to define the cellular distribution of XOR in normal and cirrhotic human liver. As shown previously, XOR is present in hepatocytes. However, the novel finding of this study is that XOR is present in bile duct epithelial cells, where it is concentrated toward the luminal surface. Moreover, in liver disease, proliferating bile ducts are also strongly positive for XOR. These findings suggest that the enzyme is secreted into bile, and this was confirmed by analysis of human and rat bile. Xanthine oxidase activity was 10 to 20-fold higher in liver tissue obtained from patients with liver disease, than in healthy liver. We conclude that XOR is expressed primarily in hepatocytes, but is also present in bile duct epithelial cells and is secreted into bile. Its role in bile is unknown but it may be involved in innate immunity of the bowel muscosa.

    Topics: Animals; Antibodies, Monoclonal; Bile; Bile Ducts; Blotting, Western; Cell Polarity; Cholangitis, Sclerosing; Electrophoresis, Polyacrylamide Gel; Epithelial Cells; Hepatitis C; Hepatocytes; Humans; Hyperoxaluria, Primary; Immunoenzyme Techniques; Liver Cirrhosis; Liver Cirrhosis, Alcoholic; Liver Cirrhosis, Biliary; Liver Diseases; Liver Diseases, Alcoholic; Mice; Mice, Inbred BALB C; Microscopy, Confocal; Rats; Rats, Sprague-Dawley; Xanthine Oxidase

2004