allopurinol and Child-Behavior-Disorders

To evaluate the long-term neurodevelopmental and behavioral outcome of antenatal allopurinol treatment during suspected fetal hypoxia.. We studied children born from women who participated in a randomized double-blind placebo controlled multicenter study (ALLO-trial). Labouring women in whom the fetus was suspected to have fetal hypoxia were randomly allocated to receive allopurinol or placebo. At 5 years of age, the children were assessed with 2 parent reported questionnaires, the Ages and Stages Questionnaire (ASQ) and the Child Behavior Checklist (CBCL). A child was marked abnormal for ASQ if it scored below 2 standard deviation under the normative mean of a reference population in at least one domain. For CBCL, a score above the cut-off value (95th percentile for narrowband scale, 85th percentile for broadband scale) in at least one scale was marked as abnormal.. We obtained data from 138 out of the original 222 mildly asphyxiated children included in the ALLO-trial (response rate 62%, allopurinol n = 73, placebo n = 65). At 5 years of age, the number of children that scored abnormal on the ASQ were 11 (15.1%) in the allopurinol group versus 11 (9.2%) in the placebo group (relative risk (RR) 1.64, 95% confidence interval (CI): 0.64 to 4.17, p = 0.30). On CBCL 21 children (30.4%) scored abnormal in de allopurinol group versus 12 children (20.0%) in the placebo group (RR 1.52, 95% CI: 0.82 to 2.83, p = 0.18).. We found no proof that allopurinol administered to labouring women with suspected fetal hypoxia improved long-term developmental and behavioral outcome. These findings are limited due to the fact that the study was potentially underpowered.. NCT00189007 Dutch Trial Register NTR1383.

Topics: Allopurinol; Child Behavior; Child Behavior Disorders; Child Development; Child, Preschool; Developmental Disabilities; Double-Blind Method; Female; Fetal Hypoxia; Follow-Up Studies; Free Radical Scavengers; Humans; Labor, Obstetric; Male; Pregnancy

Topics: Administration, Oral; Allopurinol; Child; Child Behavior Disorders; Clinical Trials as Topic; Diet Therapy; Dose-Response Relationship, Drug; Echolalia; Humans; Male; Placebos; Purines; Remission, Spontaneous; Schizophrenia; Schizophrenia, Childhood; Self Concept; Uric Acid; Xanthine Oxidase

Recurrent episodes of bizarre behavior were the only clinical symptoms that finally led to the diagnosis of ornithine transcarbamylase deficiency in an 8-year-old boy. The suspected diagnosis could not be confirmed with the use of current challenge tests. The response to a high-protein diet for 24 hours appeared to be a helpful diagnostic aid.

Topics: Allopurinol; Amino Acid Metabolism, Inborn Errors; Child Behavior Disorders; Child, Preschool; Diagnostic Errors; Dietary Proteins; Heterozygote; Humans; Male; Ornithine Carbamoyltransferase Deficiency Disease

Topics: 5-Hydroxytryptophan; Adolescent; Aggression; Allopurinol; Behavior Therapy; Child; Child Behavior Disorders; Child Development; Child, Preschool; Humans; Hypoxanthine Phosphoribosyltransferase; Infant; Lesch-Nyhan Syndrome; Male; Restraint, Physical; Self Mutilation; Stereotyped Behavior; Uric Acid

Topics: Adenine; Allopurinol; Autistic Disorder; Carbon Isotopes; Child Behavior Disorders; Child, Preschool; Erythrocytes; Glucosyltransferases; Glycine; Gout; Guanine; Humans; Hypoxanthines; Intellectual Disability; Male; Mutism; Nucleotides; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Uric Acid; Xanthenes