allopurinol has been researched along with Cerebral-Palsy* in 4 studies
1 review(s) available for allopurinol and Cerebral-Palsy
Article | Year |
---|---|
Neuroprotective strategies following perinatal hypoxia-ischemia: TakingĀ aim at NOS.
Perinatal asphyxia is characterized by oxygen deprivation and lack of perfusion in the perinatal period, leading to hypoxic-ischemic encephalopathy and sequelae such as cerebral palsy, mental retardation, cerebral visual impairment, epilepsy and learning disabilities. On cellular level PA is associated with a decrease in oxygen and glucose leading to ATP depletion and a compromised mitochondrial function. Upon reoxygenation and reperfusion, the renewed availability of oxygen gives rise to not only restoration of cell function, but also to the activation of multiple detrimental biochemical pathways, leading to secondary energy failure and ultimately, cell death. The formation of reactive oxygen species, nitric oxide and peroxynitrite plays a central role in the development of subsequent neurological damage. In this review we give insight into the pathophysiology of perinatal asphyxia, discuss its clinical relevance and summarize current neuroprotective strategies related to therapeutic hypothermia, ischemic postconditioning and pharmacological interventions. The review will also focus on the possible neuroprotective actions and molecular mechanisms of the selective neuronal and inducible nitric oxide synthase inhibitor 2-iminobiotin that may represent a novel therapeutic agent for the treatment of hypoxic-ischemic encephalopathy, both in combination with therapeutic hypothermia in middle- and high-income countries, as well as stand-alone treatment in low-income countries. Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythropoietin; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Intellectual Disability; Ischemic Postconditioning; Melatonin; Neuroprotective Agents; Pregnancy; Reactive Nitrogen Species; Reactive Oxygen Species | 2019 |
3 other study(ies) available for allopurinol and Cerebral-Palsy
Article | Year |
---|---|
Late diagnosis of Lesch-Nyhan disease complicated with end-stage renal disease and tophi burst: a case report.
Topics: Adolescent; Allopurinol; Cerebral Palsy; Delayed Diagnosis; Exons; Gout Suppressants; Humans; Hypoxanthine Phosphoribosyltransferase; Kidney Failure, Chronic; Lesch-Nyhan Syndrome; Male; Radiography, Thoracic; Renal Dialysis; Scoliosis; Uric Acid | 2020 |
[Juvenile hyperuricemia, gout and cerebral palsy (Lesch-Nyhan syndrome)].
Topics: Adolescent; Allopurinol; Athetosis; Cerebral Palsy; Chorea; Gout; Humans; Male; Uric Acid | 1969 |
Inherited disorder of purine metabolism. Correlation between central nervous system dysfunction and biochemical defects.
Topics: Adolescent; Allopurinol; Aminohydrolases; Athetosis; Brain; Central Nervous System Diseases; Cerebral Palsy; Chorea; Erythrocytes; Fibroblasts; Glucosyltransferases; Humans; Hypoxanthines; Intellectual Disability; Liver; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Self Mutilation; Spasm; Xanthines | 1967 |