allopurinol and Bone-Diseases

Topics: Allopurinol; Aluminum; Anemia; Antihypertensive Agents; Blood Transfusion; Bone Diseases; Diet Therapy; Diet, Sodium-Restricted; Diuretics; Humans; Hydroxides; Hypertension; Kidney Failure, Chronic; Palliative Care; Parathyroid Glands; Uric Acid; Vitamin D

Topics: Adrenal Cortex Hormones; Adult; Allopurinol; Autoimmune Diseases; Azathioprine; Bone Diseases; Diabetes Mellitus; Drug Synergism; Duodenal Ulcer; Embolism, Fat; Glomerulonephritis; Histocompatibility; Humans; Hypertension, Renal; Immunosuppressive Agents; Infections; Kidney Glomerulus; Kidney Transplantation; Malabsorption Syndromes; Male; Mercaptopurine; Neoplasm Transplantation; Neoplasms; Obesity; Osteoporosis; Pancreatitis; Peptic Ulcer Hemorrhage; Phenylbutazone; Postoperative Complications; Proteinuria; Transplantation, Homologous

Non-steroidal analgesic and anti-inflammatory drugs (NSAID) are potent inhibitors of prostaglandin synthesis in vivo at commonly achieved concentrations of these drugs. Prostaglandins of the E-series are released by exercising muscles, and their release is inhibited by indomethacin. The consequences, with respect to exercise performance, are unknown. Drugs used for hyperuricemia and gout such as colchicine, allopurinol, probenecid, and sulphinpyrazone have not been implicated in affecting exercise performance. The uricosuric drugs probenecid and sulphinpyrazone may be contraindicated in individuals who exercise heavily because of the increased danger of precipitating uric acid crystals in the kidney tubules. Muscle relaxants do not cause measurable muscle relaxation following usual oral dosage regimens. They are, however, sedatives and this property could influence exercise performance.

Topics: Allopurinol; Analgesics; Anti-Inflammatory Agents; Bone Diseases; Colchicine; Gout; Humans; Muscle Relaxants, Central; Muscular Diseases; Physical Exertion; Probenecid; Prostaglandins; Uric Acid

A spectrophotometric method is described for the determination of 5'-nucleotidase. In combination with the enzymes nucleoside phosphorylase and xanthine oxidase, inosine, formed by hydrolysis of 5'-IMP by 5'-nucleotidase, is cleaved phosphorolytically to hypoxanthine, which is oxidized to uric acid. In the presence of ethanol, the hydrogen peroxide formed is reduced by catalase and equivalent amounts of acetaldehyde are produced. The aldehyde is dehydrogenated (NADP-dependent) by aldehyde dehydrogenase and the production rate of NADPH is recorded at 334 nm. The inhibition of the unspecific cleavage of 5'-IMP by phosphatases is examined critically.

Topics: 5'-Nucleotidase; Aldehyde Oxidoreductases; Alkaline Phosphatase; Bone Diseases; Inosine Monophosphate; Liver Diseases; Nucleotidases; Phosphates; Purine-Nucleoside Phosphorylase; Spectrophotometry, Ultraviolet; Xanthine Oxidase

Topics: Adult; Allopurinol; Bone Diseases; Clofibrate; Diet Therapy; Dietary Carbohydrates; Femur Head Necrosis; Humans; Humerus; Hyperlipidemias; Joint Prosthesis; Knee Joint; Lipoproteins; Male; Necrosis; Prediabetic State; Triglycerides; Uric Acid