allopurinol and Anemia--Hemolytic

Topics: 5'-Nucleotidase; Adolescent; Adult; Aged; Allopurinol; Anemia, Hemolytic; Child; Child, Preschool; Consanguinity; Cytidine Diphosphate Choline; Erythrocytes; Female; Gout; Gout Suppressants; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nuclear Family

In a 37 year old renal transplant woman haemolytic anaemia was observed in the course of a combined azathioprine-allopurinol therapy. Azathioprine is converted to 6-mercaptopurine, which then catalyzed by xanthine oxidase is oxidized to 6-thiouric acid. When allopurinol and azathioprine are administered simultaneously, high 6-mercaptopurine concentrations in plasma may be expected because of inhibition of xanthine oxidase activity by allopurinol. We assume that elevated plasma 6-mercaptopurine concentration could possibly be responsible for haemolytic anaemia in this renal transplant patient.

Topics: Adult; Allopurinol; Anemia, Hemolytic; Azathioprine; Drug Therapy, Combination; Female; Humans; Kidney Transplantation; Mercaptopurine; Transplantation, Homologous

Topics: Alanine Transaminase; Alkaline Phosphatase; Anemia, Hemolytic; Aspartate Aminotransferases; Carbon Isotopes; Cholestasis; Female; Hepatitis; Humans; Infectious Mononucleosis; Liver Cirrhosis; Liver Diseases; Male; Myocardial Infarction; Neoplasms; Typhoid Fever; Xanthine Oxidase

Topics: Allopurinol; Anemia, Hemolytic; Azathioprine; Granulomatosis with Polyangiitis; Heparin; Humans; Male; Microcirculation; Middle Aged; Prednisone; Remission, Spontaneous; Thrombophlebitis