alloin and Chemical-and-Drug-Induced-Liver-Injury

As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated

Topics: Aflatoxin B1; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Disease Models, Animal; Down-Regulation; Emodin; Interleukin-1beta; Lipid Peroxidation; Liver; Male; Rats

Topics: Ammonia; Animals; Aquaporin 4; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Emodin; Ependymoglial Cells; Hepatic Encephalopathy; Liver; Male; Potassium Channels, Inwardly Rectifying; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Thioacetamide