allapinin and Ventricular-Fibrillation

Allapinin after i.v. bolus infusion in a dose of 30 mg is relatively quickly eliminated from blood (in patients without congestive heart failure half-elimination period is 2.4 +/- 0.5 h and clearance is 79.0 +/- 8.9 l/h) which makes a good reason for its intravenous infusion according to the scheme "load dose + drop infusion". Marked heart failure in patients with acute myocardial infarction compared to patients without heart failure results in reduced elimination rate, decreased clearance, significantly increased plasma allapinin concentration which should be taken in account when choosing the regime of drug infusion. The elimination of allapinin is mainly metabolic and not renal (only about 17% of the drug is excreted with urine).

Topics: Aconitine; Aconitum; Adult; Aged; Clinical Trials as Topic; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Ventricular Fibrillation