allapinin has been researched along with Myocardial-Infarction* in 3 studies
1 trial(s) available for allapinin and Myocardial-Infarction
| Article | Year |
|---|---|
[Allapinin pharmacokinetics after its single intravenous administration].
Allapinin after i.v. bolus infusion in a dose of 30 mg is relatively quickly eliminated from blood (in patients without congestive heart failure half-elimination period is 2.4 +/- 0.5 h and clearance is 79.0 +/- 8.9 l/h) which makes a good reason for its intravenous infusion according to the scheme "load dose + drop infusion". Marked heart failure in patients with acute myocardial infarction compared to patients without heart failure results in reduced elimination rate, decreased clearance, significantly increased plasma allapinin concentration which should be taken in account when choosing the regime of drug infusion. The elimination of allapinin is mainly metabolic and not renal (only about 17% of the drug is excreted with urine). Topics: Aconitine; Aconitum; Adult; Aged; Clinical Trials as Topic; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Ventricular Fibrillation | 1989 |
2 other study(ies) available for allapinin and Myocardial-Infarction
| Article | Year |
|---|---|
Effect of glialin on cardiac ventricular arrhythmias and myocardial conduction system in dogs.
Intravenous glialin in a dose of 7 mg/kg suppressed the number of ectopic contractions caused by double ligature of the left coronary artery by the method of Harris and almost 2-fold prolonged animal life-span in comparison with the control. The maximum antiarrhythmic effect of glialin developed after 180 min and persisted for 5 h. Glialin injected intravenously (10 mg/kg) after myocardial infarction under conditions of programmed electrical stimulation inhibited conduction of evoked impulse in the atria, Purkinje fibers, and ventricular myocardium and did not modify the effective refractory periods of the atria and ventricles. Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electrophysiology; Glycyrrhizic Acid; Heart Conduction System; Myocardial Infarction | 2007 |
[Hemodynamic effects of intravenous allapinine in patients with myocardial infarction].
Single intravenous allapinine, 30 mg, given to patients with acute myocardial infarction, including those with moderate circulatory insufficiency, fails to affect central hemodynamic parameters or has a favourable action: normalizes pulmonary diastolic pressure, cardiac index, diminishes total peripheral vascular resistance. The agent also produces a weak antihypertensive effect and increases heart rate. Topics: Aconitine; Adult; Anti-Arrhythmia Agents; Female; Hemodynamics; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction | 1992 |