Page last updated: 2024-10-16

allantoin and Cicatrization

allantoin has been researched along with Cicatrization in 20 studies

Cicatrization: The formation of fibrous tissue in the place of normal tissue during the process of WOUND HEALING. It includes scar tissue formation occurring in healing internal organs as well as in the skin after surface injuries.

Research Excerpts

ExcerptRelevanceReference
"The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site."7.83Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model. ( Aktaş, A; Çetinalp, NE; Özay, R; Özdemir, HM; Şekerci, Z; Yavuz, OY; Yiğit, F, 2016)
"24; p < 0."6.80Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. ( Estrugo-Devesa, A; González-Navarro, B; Jan-Pallí, E; Jané-Salas, E; lez-Navarro, BG; Lope-Lopez, J; Lopez-Lopez, J; Milani, M, 2015)
"The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site."3.83Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model. ( Aktaş, A; Çetinalp, NE; Özay, R; Özdemir, HM; Şekerci, Z; Yavuz, OY; Yiğit, F, 2016)
"24; p < 0."2.80Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. ( Estrugo-Devesa, A; González-Navarro, B; Jan-Pallí, E; Jané-Salas, E; lez-Navarro, BG; Lope-Lopez, J; Lopez-Lopez, J; Milani, M, 2015)
"A topical scar gel containing extract of Allium cepae, allantoin and heparin (Contractubex®; Merz Pharmaceuticals GmbH, Germany), has shown efficacy in improving the appearance of various scar types."2.79The prophylactic use of a topical scar gel containing extract of Allium cepae, allantoin, and heparin improves symptoms and appearance of cesarean-section scars compared with untreated scars. ( Acker, C; Buske, K; Iglesias Benavides, JL; Lehn, A; Ocampo-Candiani, J; Vázquez-Martínez, OT, 2014)
"Contractubex gel is effective in scar prevention in Chinese patients having laser removal of tattoos."2.72Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial. ( Chan, HH; Chan, PC; Ho, WS; Ying, SY, 2006)
"Additionally, the scars were characterized after a six-month treatment-free follow-up period."2.68Possibilities of scar treatment after thoracic surgery. ( Görtelmeyer, R; Maragakis, M; Michel, G; Willital, GH, 1995)
"The appearance of the scar, including scar type and scar size as well as scar colour, was assessed by the physician."2.67Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents. ( Heine, H; Willital, GH, 1994)
"Cutaneous scars (particularly hypertrophic and keloid scars), not only can cause adverse cosmetic problems, but also can be associated with emotional distress such as anxiety and depression."2.55The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management. ( Chen, CY; Fang, QQ; Huang, CL; Tan, WQ; Wang, XW; Wu, LH; Xu, JH; Zhang, LY; Zhang, MX, 2017)
"Parameters measured included scar size, color, and pliability (consistency/hardness), as well as patients' and physicians' subjective assessments of treatment efficacy and tolerability."1.39Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice. ( Simon, J; Willital, GH, 2013)
"On the 30th day, scar tissues were excised to investigate the immunohistochemical and ultrastructural effects of these agents."1.38Comparison of the effects of Contractubex® gel in an experimental model of scar formation in rats: an immunohistochemical and ultrastructural study. ( Bilac, C; Giray, G; Guzel, E; Inan, S; Muftuoglu, S; Ozturkcan, S; Sahin, MT, 2012)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19904 (20.00)18.7374
1990's2 (10.00)18.2507
2000's2 (10.00)29.6817
2010's10 (50.00)24.3611
2020's2 (10.00)2.80

Authors

AuthorsStudies
Ozay, R2
Keskin, E1
Balkan, MS1
Aktas, A2
Akturk, UD1
Esener, O1
Akturk, T1
Hanalioglu, S1
Atabey, C1
Sekerci, Z2
Gonchakov, GV1
Merkulova, YA1
Prager, W1
Gauglitz, GG1
Ocampo-Candiani, J1
Vázquez-Martínez, OT1
Iglesias Benavides, JL1
Buske, K1
Lehn, A1
Acker, C1
Kerwin, LY1
El Tal, AK1
Stiff, MA1
Fakhouri, TM1
Lopez-Lopez, J1
Lope-Lopez, J1
Jan-Pallí, E1
lez-Navarro, BG1
González-Navarro, B1
Jané-Salas, E1
Estrugo-Devesa, A1
Milani, M1
Yavuz, OY1
Yiğit, F1
Çetinalp, NE1
Özdemir, HM1
Fang, QQ1
Chen, CY1
Zhang, MX1
Huang, CL1
Wang, XW1
Xu, JH1
Wu, LH1
Zhang, LY1
Tan, WQ1
Stozkowska, W2
Raczyńska, K1
Aysan, E1
Bektas, H1
Ersoz, F1
Sari, S1
Huq, G1
Calka, O1
Omer, C1
Akdeniz, N1
Necmettin, A1
Özkol, HU1
Ozkol Hatice, U1
Karadag, AS1
Serap, KA1
Behçet, L1
Lütfi, B1
Sahin, MT1
Inan, S1
Ozturkcan, S1
Guzel, E1
Bilac, C1
Giray, G1
Muftuoglu, S1
Willital, GH3
Simon, J1
CAHEN, R1
PESSONNIER, A1
Ho, WS1
Ying, SY1
Chan, PC1
Chan, HH1
Janicki, S2
Jaśkowski, J1
Kasprzak, A1
Kondrat, W1
Heine, H1
Maragakis, M1
Michel, G1
Görtelmeyer, R1
de Buman, M1
Walther, M1
de Weck, R1
Sznitowska, M1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effectiveness and Tolerability of an Overnight 4-week Treatment With Patch Containing Onion Extract and Allantoin for Cesarean Section Scars[NCT04046783]93 participants (Actual)Observational2019-03-02Completed
A Prospective, Single-center, Randomized, Parallel Group Trial to Investigate the Efficacy of Contractubex® Gel, Containing Extractum Cepae, Allantoin, and Heparin, in Scars After Abdominal Caesarean Section[NCT01112371]Phase 461 participants (Actual)Interventional2011-02-28Completed
The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair[NCT03219580]Phase 350 participants (Anticipated)Interventional2017-05-20Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for allantoin and Cicatrization

ArticleYear
Scar prevention and remodeling: a review of the medical, surgical, topical and light treatment approaches.
    International journal of dermatology, 2014, Volume: 53, Issue:8

    Topics: Administration, Cutaneous; Allantoin; Antimitotic Agents; Botulinum Toxins, Type A; Cicatrix; Dermab

2014
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
    Current pharmaceutical design, 2017, Volume: 23, Issue:15

    Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts;

2017
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
    Current pharmaceutical design, 2017, Volume: 23, Issue:15

    Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts;

2017
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
    Current pharmaceutical design, 2017, Volume: 23, Issue:15

    Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts;

2017
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
    Current pharmaceutical design, 2017, Volume: 23, Issue:15

    Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts;

2017
[Efficiency and application safety of Cepan cream. Observation of a new indication].
    Przeglad lekarski, 2008, Volume: 65, Issue:5

    Topics: Allantoin; Animals; Blepharitis; Burns; Chamomile; Cicatrix; Drug Combinations; Drug Synergism; Eyel

2008

Trials

8 trials available for allantoin and Cicatrization

ArticleYear
[Evaluation of advantages of Contractubex gel usage for postsurgical scars treatment in comparison with absence of systematized topical scars treatment of kids with congenital cleft lip and palate].
    Khirurgiia, 2020, Issue:4

    Topics: Allantoin; Cicatrix; Cleft Lip; Cleft Palate; Dermatologic Agents; Drug Combinations; Gels; Heparin;

2020
Effectiveness and Safety of an Overnight Patch Containing Allium cepa Extract and Allantoin for Post-Dermatologic Surgery Scars.
    Aesthetic plastic surgery, 2018, Volume: 42, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Allantoin; Cicatrix; Dermatologic Agents; Dermatologic Surgical Proc

2018
The prophylactic use of a topical scar gel containing extract of Allium cepae, allantoin, and heparin improves symptoms and appearance of cesarean-section scars compared with untreated scars.
    Journal of drugs in dermatology : JDD, 2014, Volume: 13, Issue:2

    Topics: Administration, Cutaneous; Adolescent; Adult; Allantoin; Cesarean Section; Cicatrix; Drug Combinatio

2014
Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery.
    Current medical research and opinion, 2015, Volume: 31, Issue:12

    Topics: Adult; Allantoin; Analgesics; Bicarbonates; Chitosan; Chlorhexidine; Cicatrix; Cross-Over Studies; F

2015
Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2006, Volume: 32, Issue:7

    Topics: Adult; Allantoin; Cicatrix; Drug Combinations; Female; Gels; Heparin; Humans; Laser Therapy; Male; O

2006
Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents.
    International journal of clinical pharmacology research, 1994, Volume: 14, Issue:5-6

    Topics: Administration, Topical; Adolescent; Allantoin; Allium; Child; Child, Preschool; Cicatrix; Dermatolo

1994
Possibilities of scar treatment after thoracic surgery.
    Drugs under experimental and clinical research, 1995, Volume: 21, Issue:5

    Topics: Administration, Topical; Adolescent; Allantoin; Child; Child, Preschool; Cicatrix; Dermatologic Agen

1995
[Effectiveness of Alphastria cream in the prevention of pregnancy stretch marks (striae distensae). Results of a double-blind study].
    Gynakologische Rundschau, 1987, Volume: 27, Issue:2

    Topics: Allantoin; Cicatrix; Clinical Trials as Topic; Dermatologic Agents; Double-Blind Method; Drug Combin

1987

Other Studies

9 other studies available for allantoin and Cicatrization

ArticleYear
Effects of Topically Applied Contractubex® on Epidural Fibrosis and Axonal Regeneration in Injured Rat Sciatic Nerve.
    Turkish neurosurgery, 2023, Volume: 33, Issue:3

    Topics: Allantoin; Animals; Cicatrix; Male; Rats; Rats, Sprague-Dawley; Sciatic Nerve

2023
Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model.
    Turkish journal of medical sciences, 2016, Jun-23, Volume: 46, Issue:4

    Topics: Allantoin; Animals; Cicatrix; Epidural Space; Fibrosis; Heparin; Laminectomy; Male; Rats; Rats, Spra

2016
Effects of contractubex on the prevention of postoperative peritoneal adhesion.
    The Journal of surgical research, 2010, Volume: 164, Issue:2

    Topics: Allantoin; Animals; Cicatrix; Drug Combinations; Female; Heparin; Humans; Keloid; Peritoneal Cavity;

2010
Irritant contact dermatitis caused by Ranunculus kotschyi Boiss in 6 cases.
    Contact dermatitis, 2011, Volume: 64, Issue:3

    Topics: Adult; Aged; Allantoin; Anti-Bacterial Agents; Anti-Inflammatory Agents; Arthralgia; Betamethasone;

2011
Comparison of the effects of Contractubex® gel in an experimental model of scar formation in rats: an immunohistochemical and ultrastructural study.
    Journal of drugs in dermatology : JDD, 2012, Volume: 11, Issue:1

    Topics: Administration, Topical; Allantoin; Animals; Cicatrix; Disease Models, Animal; Drug Combinations; Fe

2012
Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice.
    Journal of drugs in dermatology : JDD, 2013, Volume: 12, Issue:1

    Topics: Adult; Allantoin; Cicatrix; Cohort Studies; Color; Dermatologic Agents; Diagnostic Self Evaluation;

2013
[Study of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. V. Effect on cicatrization of gastric ulcer].
    Annales pharmaceutiques francaises, 1963, Volume: 21

    Topics: Allantoin; Aluminum Hydroxide; Antacids; Bismuth; Cicatrix; Histamine; Reserpine; Stomach Ulcer

1963
[Technology and preliminary evaluation of ointments that increase the elasticity of post-burn scars].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1984, Nov-15, Volume: 37, Issue:22

    Topics: Adolescent; Adult; Allantoin; Burns; Chamomile; Child; Child, Preschool; Cicatrix; Dermatologic Agen

1984
The effect of vehicle on allantoin penetration into human skin from an ointment for improving scar elasticity.
    Die Pharmazie, 1988, Volume: 43, Issue:3

    Topics: Allantoin; Cicatrix; Elasticity; Female; Gels; Humans; Male; Ointment Bases; Ointments; Pharmaceutic

1988