allantoin has been researched along with Cicatrization in 20 studies
Cicatrization: The formation of fibrous tissue in the place of normal tissue during the process of WOUND HEALING. It includes scar tissue formation occurring in healing internal organs as well as in the skin after surface injuries.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site." | 7.83 | Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model. ( Aktaş, A; Çetinalp, NE; Özay, R; Özdemir, HM; Şekerci, Z; Yavuz, OY; Yiğit, F, 2016) |
| "24; p < 0." | 6.80 | Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. ( Estrugo-Devesa, A; González-Navarro, B; Jan-Pallí, E; Jané-Salas, E; lez-Navarro, BG; Lope-Lopez, J; Lopez-Lopez, J; Milani, M, 2015) |
| "The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site." | 3.83 | Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model. ( Aktaş, A; Çetinalp, NE; Özay, R; Özdemir, HM; Şekerci, Z; Yavuz, OY; Yiğit, F, 2016) |
| "24; p < 0." | 2.80 | Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery. ( Estrugo-Devesa, A; González-Navarro, B; Jan-Pallí, E; Jané-Salas, E; lez-Navarro, BG; Lope-Lopez, J; Lopez-Lopez, J; Milani, M, 2015) |
| "A topical scar gel containing extract of Allium cepae, allantoin and heparin (Contractubex®; Merz Pharmaceuticals GmbH, Germany), has shown efficacy in improving the appearance of various scar types." | 2.79 | The prophylactic use of a topical scar gel containing extract of Allium cepae, allantoin, and heparin improves symptoms and appearance of cesarean-section scars compared with untreated scars. ( Acker, C; Buske, K; Iglesias Benavides, JL; Lehn, A; Ocampo-Candiani, J; Vázquez-Martínez, OT, 2014) |
| "Contractubex gel is effective in scar prevention in Chinese patients having laser removal of tattoos." | 2.72 | Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial. ( Chan, HH; Chan, PC; Ho, WS; Ying, SY, 2006) |
| "Additionally, the scars were characterized after a six-month treatment-free follow-up period." | 2.68 | Possibilities of scar treatment after thoracic surgery. ( Görtelmeyer, R; Maragakis, M; Michel, G; Willital, GH, 1995) |
| "The appearance of the scar, including scar type and scar size as well as scar colour, was assessed by the physician." | 2.67 | Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents. ( Heine, H; Willital, GH, 1994) |
| "Cutaneous scars (particularly hypertrophic and keloid scars), not only can cause adverse cosmetic problems, but also can be associated with emotional distress such as anxiety and depression." | 2.55 | The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management. ( Chen, CY; Fang, QQ; Huang, CL; Tan, WQ; Wang, XW; Wu, LH; Xu, JH; Zhang, LY; Zhang, MX, 2017) |
| "Parameters measured included scar size, color, and pliability (consistency/hardness), as well as patients' and physicians' subjective assessments of treatment efficacy and tolerability." | 1.39 | Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice. ( Simon, J; Willital, GH, 2013) |
| "On the 30th day, scar tissues were excised to investigate the immunohistochemical and ultrastructural effects of these agents." | 1.38 | Comparison of the effects of Contractubex® gel in an experimental model of scar formation in rats: an immunohistochemical and ultrastructural study. ( Bilac, C; Giray, G; Guzel, E; Inan, S; Muftuoglu, S; Ozturkcan, S; Sahin, MT, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 10 (50.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozay, R | 2 |
| Keskin, E | 1 |
| Balkan, MS | 1 |
| Aktas, A | 2 |
| Akturk, UD | 1 |
| Esener, O | 1 |
| Akturk, T | 1 |
| Hanalioglu, S | 1 |
| Atabey, C | 1 |
| Sekerci, Z | 2 |
| Gonchakov, GV | 1 |
| Merkulova, YA | 1 |
| Prager, W | 1 |
| Gauglitz, GG | 1 |
| Ocampo-Candiani, J | 1 |
| Vázquez-Martínez, OT | 1 |
| Iglesias Benavides, JL | 1 |
| Buske, K | 1 |
| Lehn, A | 1 |
| Acker, C | 1 |
| Kerwin, LY | 1 |
| El Tal, AK | 1 |
| Stiff, MA | 1 |
| Fakhouri, TM | 1 |
| Lopez-Lopez, J | 1 |
| Lope-Lopez, J | 1 |
| Jan-Pallí, E | 1 |
| lez-Navarro, BG | 1 |
| González-Navarro, B | 1 |
| Jané-Salas, E | 1 |
| Estrugo-Devesa, A | 1 |
| Milani, M | 1 |
| Yavuz, OY | 1 |
| Yiğit, F | 1 |
| Çetinalp, NE | 1 |
| Özdemir, HM | 1 |
| Fang, QQ | 1 |
| Chen, CY | 1 |
| Zhang, MX | 1 |
| Huang, CL | 1 |
| Wang, XW | 1 |
| Xu, JH | 1 |
| Wu, LH | 1 |
| Zhang, LY | 1 |
| Tan, WQ | 1 |
| Stozkowska, W | 2 |
| Raczyńska, K | 1 |
| Aysan, E | 1 |
| Bektas, H | 1 |
| Ersoz, F | 1 |
| Sari, S | 1 |
| Huq, G | 1 |
| Calka, O | 1 |
| Omer, C | 1 |
| Akdeniz, N | 1 |
| Necmettin, A | 1 |
| Özkol, HU | 1 |
| Ozkol Hatice, U | 1 |
| Karadag, AS | 1 |
| Serap, KA | 1 |
| Behçet, L | 1 |
| Lütfi, B | 1 |
| Sahin, MT | 1 |
| Inan, S | 1 |
| Ozturkcan, S | 1 |
| Guzel, E | 1 |
| Bilac, C | 1 |
| Giray, G | 1 |
| Muftuoglu, S | 1 |
| Willital, GH | 3 |
| Simon, J | 1 |
| CAHEN, R | 1 |
| PESSONNIER, A | 1 |
| Ho, WS | 1 |
| Ying, SY | 1 |
| Chan, PC | 1 |
| Chan, HH | 1 |
| Janicki, S | 2 |
| Jaśkowski, J | 1 |
| Kasprzak, A | 1 |
| Kondrat, W | 1 |
| Heine, H | 1 |
| Maragakis, M | 1 |
| Michel, G | 1 |
| Görtelmeyer, R | 1 |
| de Buman, M | 1 |
| Walther, M | 1 |
| de Weck, R | 1 |
| Sznitowska, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effectiveness and Tolerability of an Overnight 4-week Treatment With Patch Containing Onion Extract and Allantoin for Cesarean Section Scars[NCT04046783] | 93 participants (Actual) | Observational | 2019-03-02 | Completed | |||
| A Prospective, Single-center, Randomized, Parallel Group Trial to Investigate the Efficacy of Contractubex® Gel, Containing Extractum Cepae, Allantoin, and Heparin, in Scars After Abdominal Caesarean Section[NCT01112371] | Phase 4 | 61 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
| The Role of 5-Fluorouracil in Post-Operative Scar Formation Following Direct Brow Ptosis Repair[NCT03219580] | Phase 3 | 50 participants (Anticipated) | Interventional | 2017-05-20 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for allantoin and Cicatrization
| Article | Year |
|---|---|
Scar prevention and remodeling: a review of the medical, surgical, topical and light treatment approaches.
Topics: Administration, Cutaneous; Allantoin; Antimitotic Agents; Botulinum Toxins, Type A; Cicatrix; Dermab | 2014 |
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts; | 2017 |
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts; | 2017 |
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts; | 2017 |
The Effectiveness of Topical Anti-scarring Agents and a Novel Combined Process on Cutaneous Scar Management.
Topics: Administration, Topical; Allantoin; Cicatrix; Drug Combinations; Heparin; Ointments; Plant Extracts; | 2017 |
[Efficiency and application safety of Cepan cream. Observation of a new indication].
Topics: Allantoin; Animals; Blepharitis; Burns; Chamomile; Cicatrix; Drug Combinations; Drug Synergism; Eyel | 2008 |
8 trials available for allantoin and Cicatrization
| Article | Year |
|---|---|
[Evaluation of advantages of Contractubex gel usage for postsurgical scars treatment in comparison with absence of systematized topical scars treatment of kids with congenital cleft lip and palate].
Topics: Allantoin; Cicatrix; Cleft Lip; Cleft Palate; Dermatologic Agents; Drug Combinations; Gels; Heparin; | 2020 |
Effectiveness and Safety of an Overnight Patch Containing Allium cepa Extract and Allantoin for Post-Dermatologic Surgery Scars.
Topics: Adult; Aged; Aged, 80 and over; Allantoin; Cicatrix; Dermatologic Agents; Dermatologic Surgical Proc | 2018 |
The prophylactic use of a topical scar gel containing extract of Allium cepae, allantoin, and heparin improves symptoms and appearance of cesarean-section scars compared with untreated scars.
Topics: Administration, Cutaneous; Adolescent; Adult; Allantoin; Cesarean Section; Cicatrix; Drug Combinatio | 2014 |
Efficacy of chlorhexidine, dexpanthenol, allantoin and chitosan gel in comparison with bicarbonate oral rinse in controlling post-interventional inflammation, pain and cicatrization in subjects undergoing dental surgery.
Topics: Adult; Allantoin; Analgesics; Bicarbonates; Chitosan; Chlorhexidine; Cicatrix; Cross-Over Studies; F | 2015 |
Use of onion extract, heparin, allantoin gel in prevention of scarring in chinese patients having laser removal of tattoos: a prospective randomized controlled trial.
Topics: Adult; Allantoin; Cicatrix; Drug Combinations; Female; Gels; Heparin; Humans; Laser Therapy; Male; O | 2006 |
Efficacy of Contractubex gel in the treatment of fresh scars after thoracic surgery in children and adolescents.
Topics: Administration, Topical; Adolescent; Allantoin; Allium; Child; Child, Preschool; Cicatrix; Dermatolo | 1994 |
Possibilities of scar treatment after thoracic surgery.
Topics: Administration, Topical; Adolescent; Allantoin; Child; Child, Preschool; Cicatrix; Dermatologic Agen | 1995 |
[Effectiveness of Alphastria cream in the prevention of pregnancy stretch marks (striae distensae). Results of a double-blind study].
Topics: Allantoin; Cicatrix; Clinical Trials as Topic; Dermatologic Agents; Double-Blind Method; Drug Combin | 1987 |
9 other studies available for allantoin and Cicatrization
| Article | Year |
|---|---|
Effects of Topically Applied Contractubex® on Epidural Fibrosis and Axonal Regeneration in Injured Rat Sciatic Nerve.
Topics: Allantoin; Animals; Cicatrix; Male; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 2023 |
Effects of cepae extract, allantoin, and heparin mixture on developing andalready formed epidural fibrosis in a rat laminectomy model.
Topics: Allantoin; Animals; Cicatrix; Epidural Space; Fibrosis; Heparin; Laminectomy; Male; Rats; Rats, Spra | 2016 |
Effects of contractubex on the prevention of postoperative peritoneal adhesion.
Topics: Allantoin; Animals; Cicatrix; Drug Combinations; Female; Heparin; Humans; Keloid; Peritoneal Cavity; | 2010 |
Irritant contact dermatitis caused by Ranunculus kotschyi Boiss in 6 cases.
Topics: Adult; Aged; Allantoin; Anti-Bacterial Agents; Anti-Inflammatory Agents; Arthralgia; Betamethasone; | 2011 |
Comparison of the effects of Contractubex® gel in an experimental model of scar formation in rats: an immunohistochemical and ultrastructural study.
Topics: Administration, Topical; Allantoin; Animals; Cicatrix; Disease Models, Animal; Drug Combinations; Fe | 2012 |
Efficacy of early initiation of a gel containing extractum cepae, heparin, and allantoin for scar treatment: an observational, noninterventional study of daily practice.
Topics: Adult; Allantoin; Cicatrix; Cohort Studies; Color; Dermatologic Agents; Diagnostic Self Evaluation; | 2013 |
[Study of dihydroxyaluminum allantoinate and chlorhydroxyaluminum allantoinate. V. Effect on cicatrization of gastric ulcer].
Topics: Allantoin; Aluminum Hydroxide; Antacids; Bismuth; Cicatrix; Histamine; Reserpine; Stomach Ulcer | 1963 |
[Technology and preliminary evaluation of ointments that increase the elasticity of post-burn scars].
Topics: Adolescent; Adult; Allantoin; Burns; Chamomile; Child; Child, Preschool; Cicatrix; Dermatologic Agen | 1984 |
The effect of vehicle on allantoin penetration into human skin from an ointment for improving scar elasticity.
Topics: Allantoin; Cicatrix; Elasticity; Female; Gels; Humans; Male; Ointment Bases; Ointments; Pharmaceutic | 1988 |