alitretinoin and Malaria--Falciparum

alitretinoin has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for alitretinoin and Malaria--Falciparum

Article	Year
Mechanism of protection induced by vitamin A in falciparum malaria. Lancet (London, England), 2002, Apr-20, Volume: 359, Issue:9315 Supplementation with vitamin A potentiates host resistance to malaria, however, the underlying mechanism is unknown. We tested the effects of 9-cis-retinoic acid, a metabolite of vitamin A, on CD36 expression, non-opsonic phagocytic clearance of parasitised erythrocytes, and TNFalpha production in human monocytes and macrophages. We found reduced secretion of TNFalpha, upregulated CD36 expression, and increased phagocytosis of Plasmodium falciparum-parasitised erythrocytes. Increased parasite clearance and reduced proinflammatory cytokine responses to infection might partly explain the beneficial effects of supplementation with vitamin A in malaria. Topics: Alitretinoin; Animals; Antiprotozoal Agents; CD36 Antigens; Child; Erythrocytes; Humans; Malaria, Falciparum; Phagocytosis; Plasmodium falciparum; Tretinoin; Tumor Necrosis Factor-alpha; Up-Regulation; Vitamin A	2002

Article

Year

Mechanism of protection induced by vitamin A in falciparum malaria.

Lancet (London, England), 2002, Apr-20, Volume: 359, Issue:9315

Supplementation with vitamin A potentiates host resistance to malaria, however, the underlying mechanism is unknown. We tested the effects of 9-cis-retinoic acid, a metabolite of vitamin A, on CD36 expression, non-opsonic phagocytic clearance of parasitised erythrocytes, and TNFalpha production in human monocytes and macrophages. We found reduced secretion of TNFalpha, upregulated CD36 expression, and increased phagocytosis of Plasmodium falciparum-parasitised erythrocytes. Increased parasite clearance and reduced proinflammatory cytokine responses to infection might partly explain the beneficial effects of supplementation with vitamin A in malaria.

Topics: Alitretinoin; Animals; Antiprotozoal Agents; CD36 Antigens; Child; Erythrocytes; Humans; Malaria, Falciparum; Phagocytosis; Plasmodium falciparum; Tretinoin; Tumor Necrosis Factor-alpha; Up-Regulation; Vitamin A

2002