alitretinoin and Hypersensitivity

Vitamin A is a potent regulator of adaptive immunity. The effect of the endogenous metabolite 9-cis retinoic acid (9cRA) on allergic sensitization is unknown.. We sought to investigate whether and to what extent 9cRA modulates the humoral immune response.. BALB/c mice were sensitized and challenged with ovalbumin (OVA). 9cRA was applied repeatedly together with the antigen. Immunoglobulin production and cellular analysis were performed by using ELISA, ELISpot, and flow cytometry. Human CD19. 9cRA applied together with repeated OVA challenge transiently increased specific serum IgA, IgE, and IgG. Our data indicate that 9cRA modulates the allergic immune response by reducing the IgE response but promoting the IgA response. Thus 9cRA can modulate the allergic immune response toward a non-IgE condition.

Topics: Alitretinoin; Animals; Antibody Formation; B-Lymphocytes; B7-2 Antigen; Cell Movement; Female; Humans; Hypersensitivity; Immunity, Humoral; Immunoglobulin A; Immunoglobulin E; Interleukin-10; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Spleen