alisol-b-monoacetate has been researched along with Hypercholesterolemia* in 1 studies
1 other study(ies) available for alisol-b-monoacetate and Hypercholesterolemia
Article | Year |
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Alisol B 23-acetate, a new promoter for cholesterol efflux from dendritic cells, alleviates dyslipidemia and inflammation in advanced atherosclerotic mice.
Atherosclerosis (AS) is characterized by dyslipidemia and chronic inflammation. In the high-fat environment, the lipid metabolism of dendritic cells (DCs) is abnormal, which leads to abnormal immune function, promotes the occurrence of immune inflammatory reactions, and promotes the development of AS. Alisol B 23-acetate (23B) is a triterpenoid in the rhizomes of Alisma, which is a traditional Chinese medicine. Here, we identified cholesterol metabolism-related targets of 23B through a virtual screen, and further transcriptome analysis revealed that 23B can change antigen presentation and cholesterol metabolism pathways in cholesterol-loaded DCs. In vitro experiments confirmed that 23B promoted cholesterol efflux from ApoE Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholestenones; Cholesterol; Cytokines; Dendritic Cells; Disease Models, Animal; Dyslipidemias; Humans; Hypercholesterolemia; Inflammation; Lipid Metabolism; Male; Mice; Signal Transduction; T-Lymphocytes, Regulatory; T-Lymphocytopenia, Idiopathic CD4-Positive | 2021 |