alisol-b-monoacetate and Hypercholesterolemia

Atherosclerosis (AS) is characterized by dyslipidemia and chronic inflammation. In the high-fat environment, the lipid metabolism of dendritic cells (DCs) is abnormal, which leads to abnormal immune function, promotes the occurrence of immune inflammatory reactions, and promotes the development of AS. Alisol B 23-acetate (23B) is a triterpenoid in the rhizomes of Alisma, which is a traditional Chinese medicine. Here, we identified cholesterol metabolism-related targets of 23B through a virtual screen, and further transcriptome analysis revealed that 23B can change antigen presentation and cholesterol metabolism pathways in cholesterol-loaded DCs. In vitro experiments confirmed that 23B promoted cholesterol efflux from ApoE

Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cholestenones; Cholesterol; Cytokines; Dendritic Cells; Disease Models, Animal; Dyslipidemias; Humans; Hypercholesterolemia; Inflammation; Lipid Metabolism; Male; Mice; Signal Transduction; T-Lymphocytes, Regulatory; T-Lymphocytopenia, Idiopathic CD4-Positive