alisol-a has been researched along with Neoplasms* in 1 studies
1 other study(ies) available for alisol-a and Neoplasms
| Article | Year |
|---|---|
Study on antitumor molecular mechanism of Alisols based on p53DNA.
Methyl thiazolyl tetrazolium (MTT) assay, UV-vis absorption spectroscopy, fluorescence spectroscopy and molecular simulation were used to investigate the antitumor activity of alisol A, alisol B and an 1:1 mixture of both compounds, the mechanism of its interaction with anti-cancer target p53DNA and explored the antitumor mechanism of alisols. MTT assay showed that the order of antitumor activity was:alisol B > alisol A > alisol A-alisol B(1:1). Spectroscopic experiments and molecular simulation suggested that alisol A, alisol B and their mixture interact with p53DNA in by partial insertion and the strength of binding affinity was consistent with the MTT assay. The K Topics: Antineoplastic Agents; Cholestenones; DNA; Humans; MCF-7 Cells; Neoplasms; Tumor Suppressor Protein p53 | 2018 |