aliskiren and Alzheimer-Disease

The neurotoxicity of amyloid-β (Aβ) and its deposition in neurons plays a critical role in the occurrence and development of Alzheimer's disease (AD). Several preclinical experiments have found that the renin inhibitor aliskiren has a wide range of physiological effects, including hindering the progression of atherosclerosis and anti-inflammatory. This study is aimed to explore the effect of aliskiren on neuronal toxic damage and the underlying mechanism. This study established an

Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Apoptosis; Cell Line, Tumor; Fumarates; Humans; Molecular Docking Simulation; Neurons; Peptide Fragments; Renin