Page last updated: 2024-10-22

alfuzosin and Constipation

alfuzosin has been researched along with Constipation in 1 studies

alfuzosin: structure given in first source

Constipation: Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections.

Research Excerpts

Excerpt	Relevance	Reference
"In a double-blind study performed from March 2013 through March 2017, anal pressures were evaluated before and after 36 women with DD (constipation for at least 1 year) and 36 healthy women (controls) were randomly assigned (1:1) to groups given oral alfuzosin (2."	5.30	Effects of Alfuzosin, an α ( Bailey, KR; Bharucha, AE; Chakraborty, S; Feuerhak, K; Harmsen, WS; Muthyala, A, 2019)

Research

Studies (1)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chakraborty, S	1
Feuerhak, K	1
Muthyala, A	1
Harmsen, WS	1
Bailey, KR	1
Bharucha, AE	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Effect of Stress and a Alpha-1 Antagonist on Anorectal Functions[NCT01834729]			Phase 2	74 participants (Actual)	Interventional	2013-03-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Weekly Rate of Complete Spontaneous Bowel Movements at 4 Weeks

If the subject indicates that the spontaneous bowel movement (SBM) was associated with a sensation of complete bowel emptying, the SBM will be counted as a complete spontaneous bowel movement (CSBM). (NCT01834729)
Timeframe: 4 weeks

Intervention	complete SBM per week (Mean)
Control Placebo	0.6
Control Alfuzosin	0.7
Constipation Placebo	0.7
Constipation Alfuzosin	0.7

Weekly Rate of Spontaneous Bowel Movements at 4 Weeks

A bowel movement is considered a spontaneous bowel movement (SBM) if no laxative, enema, or suppository was taken in the preceding 24 hours. (NCT01834729)
Timeframe: 4 weeks

Intervention	spontaneous bowel movements per week (Mean)
Control Placebo	1.6
Control Alfuzosin	1.3
Constipation Placebo	1.6
Constipation Alfuzosin	1.3

Trials

1 trial available for alfuzosin and Constipation

Article	Year
Effects of Alfuzosin, an α Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2019, Volume: 17, Issue:6 Topics: Adrenergic alpha-1 Receptor Antagonists; Adult; Anal Canal; Constipation; Defecation; Double-Blind M	2019