alfaprostol and Swine-Diseases

In a large pig production unit 60 postparturient sows were divided at random into 3 groups, each with 20 sows. Group 1 (20 sows) received 30 g Farmavet Trisulfa per os daily from the beginning of the postfarrowing period for 1 week. Group 2 (20 sows) received 30 g Farmavet Trisulfa per os daily from the beginning of the postfarrowing period for 1 week, and in addition were given 3 mg Gabbrostim 24-48 hours after farrowing in a single i.m. application. Group 3 (20 sows) untreated control. The following parameters were evaluated: A: number of weaned piglets per sow, B: weaning to service interval in days, C: return to oestrus in percent. Both groups 1 and 2 showed better results when compared to the control group. Group 2 was superior to group 1.

Topics: Administration, Oral; Animal Feed; Animals; Drug Combinations; Estrus; Female; Female Urogenital Diseases; Lactation; Postpartum Period; Prostaglandins F; Sulfamethazine; Sulfanilamides; Sulfathiazole; Sulfathiazoles; Swine; Swine Diseases; Trimethoprim

In an intensive pig production unit with routinely performed prostaglandin partus induction four groups of sows were formed shortly before parturition. The animals received 3 mg alfaprostol as a single intramuscular injection each. The sows of group 1 on the 112th, those of group 2 on the 113th and the animals of group 3 on the 114th day of pregnancy. Group 4 sows were not treated and formed the control group. We evaluated the number of live born piglets and the number of piglets born with congenital myofibrillar hypoplasia. The results showed no significant difference regarding live born piglets. As regards congenital myofibrillar hypoplasia the sows with early partus induction (group 1) showed significant higher incidence when compared to the other groups. It is likely that in cases of partus induction before the 113th day of pregnancy the fetus is still insufficiently protected by natural maturation, adaptation and tolerance ability against such congenital condition as CMH. Therefore it is the opinion of the authors that partus induction before the 113th day of pregnancy should not be performed.

Topics: Animals; Female; Incidence; Labor, Induced; Myofibrils; Pregnancy; Prostaglandins F; Swine; Swine Diseases; Time Factors

In a single large pig production unit of 6000 breeding sows, seven groups of 100 sows each were formed at random on the 110th day of pregnancy. Each group was evaluated and divided according to body condition in three subgroups. The average parity in each subgroup was recorded. The groups were treated as follows: Group 1 received on the 113th day of pregnancy a 3 mg single intramuscular dose of alfaprostol. Group 2 received on the 113th day of pregnancy a 3 mg single intramuscular dose of alfaprostol, 24 hours later a single intramuscular dose of 10 IU of oxytocin. Group 3 received a single intramuscular dose of 10 IU of oxytocin after the birth of the first piglet. Group 4 received on the 113th day of pregnancy a 100 mg single intramuscular dose of prednisolone. Group 5 received on the 113th day of pregnancy a 0.2 mg single intramuscular dose of carbamylcholine. Group 6 received from the 110th day of pregnancy food consisting of 12% fiber, 3 kg per sow per day. Group 7 (control) received a 3 ml physiologic NaCl solution on the 114th day of pregnancy. The following parameter were evaluated: A: Number of live born piglets B: Number of intrapartum stillborn piglets As regard number of live born piglets no significant difference was seen between the experimental groups (1-6) and the control group (7). On the other hand showed the experimental group 1, 2, 5 and 6 significant lower incidence of intrapartum stillbirth when compared to the control (group 7). Within the groups the tendency was seen, that the sows with higher parity and body condition produced less numbers of live born and higher numbers of intrapartum stillborn piglets.

Topics: Animals; Carbachol; Female; Fetal Death; Nutritional Status; Oxytocin; Parity; Prednisolone; Pregnancy; Prostaglandins F; Swine; Swine Diseases

In a single large pig production unit of 6,000 breeding sows, 3 Groups of 100 sows each were formed at random on the 110th day of pregnancy. Each Group was evaluated and divided according of body condition in three Subgroups. The Groups were treated as follows: Group 1: received on the 113th day of pregnancy a 3 mg single intramuscular dose of Alfaprostol. Group 2: received on the 113th day of pregnancy a 100 mg single intramuscular dose of Prednisolone. Group 3: received a 3 ml intramuscular dose of physiologic NaCL solution on the 113th day of pregnancy. The Parameter "intrapartum dead piglets" was evaluated. Groups 1 and 2 show better results compared to Group 3 (57 and 55 to 90). Between Group 1 and 2 was no significant difference. Regarding Subgroup 5 (chosen according to body condition), the intrapartum mortality is significantly different between Group 3 and Groups 1 and 2 (%: G 1/5 17.64, G 2/5 22.35, G 3/5 31.08; +/-: G 1/5 1.71, G 2/5 2.37, G 3/5 3.83; SD G 1/5 1.60, G2/5 1.40, G 3/5 2.78). These results show, that in the case of overweight sows, where the birth passage is a priori narrower due to the presence of surrounding fatty tissue, birth is more difficult. As Groups 1 and 2 show compared to Group 3, Alfaprostol or Prednisolone is an effective help against intrapartum mortality in overweight sows (i. e. in Subgroup 5). From the results it is also to be seen, that the above-mentioned veterinary measures help less in reducing intrapartum mortality in thinner sows.

Topics: Animals; Female; Fetal Death; Obesity; Prednisolone; Pregnancy; Pregnancy Complications; Prostaglandins F; Swine; Swine Diseases; Thinness

In a single large pig production unit of 6,000 breeding sows, 3 Groups of 100 sows each were formed at random on the 110th day of pregnancy. Each Group was evaluated and divided according to body condition in three subgroups. The Groups were treated as follows: Group 1: received on the 113th day of pregnancy a 3 mg single intramuscular dose of Alfaprostol, 24 hours later a single intramuscular dose of 10 i.U. of Oxytocin. Group 2: received on the 113th day of pregnancy a 0.2 mg single intramuscular dose of Carbamylcholin. Group 3: received a 3 ml intramuscular dose of physiologic NaCl solution on the 113th day of pregnancy. The parameter "intrapartal dead piglets" was evaluated. Group 1 and 2, especially in Subgroups KK3, showed significant less intrapartal death when compared to Group 3.

Topics: Animals; Carbachol; Drug Therapy, Combination; Female; Fetal Death; Health Status; Oxytocin; Pregnancy; Prostaglandins F; Swine; Swine Diseases