alexidine has been researched along with Niemann-Pick Disease, Type C in 1 studies
alexidine: until June 1975 was mistakenly treated as synonym for chlorhexidine; RN given refers to parent cpd
alexidine : An amphipathic bisbiguanide with a structure consisting of two (2-ethylhexyl)guanide units linked by a hexamethylene bridge.
Niemann-Pick Disease, Type C: An autosomal recessive lipid storage disorder that is characterized by accumulation of CHOLESTEROL and SPHINGOMYELINS in cells of the VISCERA and the CENTRAL NERVOUS SYSTEM. Type C (or C1) and type D are allelic disorders caused by mutation of the NPC1 gene, which encodes a protein that mediates intracellular cholesterol transport from LYSOSOMES. Clinical signs include hepatosplenomegaly and chronic neurological symptoms. Type D is a variant in people with a Nova Scotia ancestry.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pugach, EK | 1 |
| Feltes, M | 1 |
| Kaufman, RJ | 1 |
| Ory, DS | 1 |
| Bang, AG | 1 |
1 other study available for alexidine and Niemann-Pick Disease, Type C
| Article | Year |
|---|---|
High-content screen for modifiers of Niemann-Pick type C disease in patient cells.
Topics: Biguanides; Carrier Proteins; Cholesterol; Drug Evaluation, Preclinical; Endoplasmic Reticulum; Fibr | 2018 |