Page last updated: 2024-10-22

alendronate and Pregnancy

alendronate has been researched along with Pregnancy in 22 studies

alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" Taking into account their medical past, two drugs were possibly involved: either oral alendronate that their mother had received before pregnancy for misdiagnosed osteoporosis or antireflux medications, or both."7.83Neonatal transient hypophosphatemic hypercalciuric rickets in dizygous twins: A role for maternal alendronate therapy before pregnancy or antireflux medications? ( Bacchetta, J; Claris, O; Cochat, P; Fouque-Aubert, A; Gerin, M; Jambon, G; Raybaud, C, 2016)
" Taking into account their medical past, two drugs were possibly involved: either oral alendronate that their mother had received before pregnancy for misdiagnosed osteoporosis or antireflux medications, or both."3.83Neonatal transient hypophosphatemic hypercalciuric rickets in dizygous twins: A role for maternal alendronate therapy before pregnancy or antireflux medications? ( Bacchetta, J; Claris, O; Cochat, P; Fouque-Aubert, A; Gerin, M; Jambon, G; Raybaud, C, 2016)
"Alendronate sodium is an aminobiphosphonate, an analog of inorganic pyrophosphate, indicated for the treatment of osteoporosis in post-menopausal women."3.72Pharmacovigilance study of alendronate in England. ( Biswas, PN; Shakir, SA; Wilton, LV, 2003)
"Osteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture."1.72Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model. ( Amorim, T; Bastos, AR; Canadas, RF; Carrillo, AE; Correlo, VM; Fernandes, EM; Freitas, L; Gkiata, P; Koutedakis, Y; Kydonaki, EK; Marques, F; Ntina, G; Oliveira, JM; Pinto, R; Reguengo, H; Reis, RL; Simón, CR; Vliora, M, 2022)
" We also show that temporary administration of the bisphosphonate alendronate, either just before or just after pregnancy, to female mice was protective against bone loss due to pregnancy or lactation and had no adverse effects on offspring, such as growth retardation."1.62Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring. ( Ito, E; Kimura, A; Kobayashi, T; Matsumoto, H; Matsumoto, M; Matsumoto, T; Miyamoto, K; Miyamoto, T; Nakamura, M; Sato, K; Sato, Y; Soma, T, 2021)
"Many women now survive breast cancer, but find themselves at increased risk of menopausal complications."1.31Managing menopause after breast cancer: balancing risks and benefits. ( Moore, HC, 2001)
"14C-alendronate was shown to pass through the rat placenta and accumulate in the fetuses, most probably in their bones."1.30Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. ( Breuer, E; Golomb, G; Ornoy, A; Patlas, N; Pinto, T; Yaffe, P, 1999)
"Alendronate is a bisphosphonate which inhibits bone resorption."1.29Effects of the bisphosphonate, alendronate, on parturition in the rat. ( Manson, JM; Minsker, DH; Peter, CP, 1993)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (13.64)18.2507
2000's10 (45.45)29.6817
2010's3 (13.64)24.3611
2020's6 (27.27)2.80

Authors

AuthorsStudies
Kydonaki, EK1
Freitas, L1
Reguengo, H1
Simón, CR1
Bastos, AR1
Fernandes, EM1
Canadas, RF1
Oliveira, JM1
Correlo, VM1
Reis, RL1
Vliora, M1
Gkiata, P1
Koutedakis, Y1
Ntina, G1
Pinto, R1
Carrillo, AE1
Marques, F1
Amorim, T1
Eswarakumar, A1
Robinson, C1
Carpenter, TO1
Bacchetta, J2
Garnier, C1
Jia, P1
Wang, R1
Yuan, J1
Chen, H1
Bao, L1
Feng, F1
Tang, H1
Sifrig, B1
Grozenski, A1
Brown, L1
Coleman, J1
Ito, E1
Sato, Y1
Kobayashi, T1
Soma, T1
Matsumoto, T1
Kimura, A1
Miyamoto, K1
Matsumoto, H1
Matsumoto, M1
Nakamura, M1
Sato, K1
Miyamoto, T1
Gerin, M1
Jambon, G1
Fouque-Aubert, A1
Raybaud, C1
Cochat, P1
Claris, O1
Ofluoglu, O1
Ofluoglu, D1
McKenna, M1
Mansfield, JC1
Rozenbaum, M1
Boulman, N1
Rimar, D1
Kaly, L1
Rosner, I1
Slobodin, G1
Dytfeld, J1
Horst-Sikorska, W1
Biswas, PN1
Wilton, LV1
Shakir, SA1
Rutgers-Verhage, AR1
deVries, TW1
Torringa, MJ1
Sarikaya, S1
Ozdolap, S1
Açikgöz, G1
Erdem, CZ1
Kabi, F1
Mkinsi, O1
Zrigui, J1
Ornoy, A2
Wajnberg, R1
Diav-Citrin, O1
Athimulam, S1
Chan, P1
Baker, M1
Nauta, M1
Yoong, W1
Minsker, DH1
Manson, JM1
Peter, CP1
van Beek, ER1
Löwik, CW1
Ebetino, FH1
Papapoulos, SE1
Patlas, N1
Golomb, G1
Yaffe, P1
Pinto, T1
Breuer, E1
Moore, HC1
Harsch, IA1
Hübner, RH1
Hahn, EG1
Hensen, J1

Reviews

1 review available for alendronate and Pregnancy

ArticleYear
A case of pregnancy and lactation-associated osteoporosis and a review of the literature.
    Archives of osteoporosis, 2020, 06-25, Volume: 15, Issue:1

    Topics: Adult; Alendronate; Bone Density; Bone Density Conservation Agents; Calcium Carbonate; Drug Therapy,

2020

Other Studies

21 other studies available for alendronate and Pregnancy

ArticleYear
Pharmacological and Non-Pharmacological Agents versus Bovine Colostrum Supplementation for the Management of Bone Health Using an Osteoporosis-Induced Rat Model.
    Nutrients, 2022, Jul-11, Volume: 14, Issue:14

    Topics: Alendronate; Animals; Body Weight; Bone Density; Cattle; Colostrum; Dietary Supplements; Female; Hum

2022
Response to report of rickets in twins occurring after maternal bisphosphonate exposure.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2020, Volume: 27, Issue:4

    Topics: Alendronate; Familial Hypophosphatemic Rickets; Female; Humans; Hypercalciuria; Infant, Newborn; Pre

2020
Response to: Neonatal transient hypophosphatemic hypercalciuric rickets in dizygous twins.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2020, Volume: 27, Issue:4

    Topics: Alendronate; Familial Hypophosphatemic Rickets; Female; Humans; Hypercalciuria; Infant, Newborn; Pre

2020
An Uncommon Cause of Debilitating Hip Pain in Pregnancy.
    Current sports medicine reports, 2021, Feb-01, Volume: 20, Issue:2

    Topics: Adult; Alendronate; Arthralgia; Bed Rest; Bone Density Conservation Agents; Crutches; Female; Hip; H

2021
Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring.
    Bone, 2021, Volume: 153

    Topics: Alendronate; Animals; Bone Density; Female; Humans; Lactation; Mice; Mothers; Pharmaceutical Prepara

2021
Neonatal transient hypophosphatemic hypercalciuric rickets in dizygous twins: A role for maternal alendronate therapy before pregnancy or antireflux medications?
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2016, Volume: 23, Issue:9

    Topics: Alendronate; Anti-Ulcer Agents; Bone Density Conservation Agents; Esomeprazole; Female; Humans; Hype

2016
A case report: pregnancy-induced severe osteoporosis with eight vertebral fractures.
    Rheumatology international, 2008, Volume: 29, Issue:2

    Topics: Adult; Alendronate; Back Pain; Bone Density; Bone Density Conservation Agents; Female; Fractures, Sp

2008
Safety of bisphosphonates in women of child bearing age.
    Alimentary pharmacology & therapeutics, 2009, Jun-01, Volume: 29, Issue:11

    Topics: Alendronate; Bone Density Conservation Agents; Colitis, Ulcerative; Diphosphonates; Female; Humans;

2009
Uncommon transient osteoporosis of pregnancy at multiple sites associated with cytomegalovirus infection: is there a link?
    The Israel Medical Association journal : IMAJ, 2011, Volume: 13, Issue:11

    Topics: Absorptiometry, Photon; Adult; Alendronate; Ankle Joint; Bone Density Conservation Agents; Cytomegal

2011
Pregnancy associated osteoporosis--a case report.
    Ginekologia polska, 2012, Volume: 83, Issue:5

    Topics: Adult; Alendronate; Back Pain; Bone Density; Bone Density Conservation Agents; Calcium, Dietary; Fem

2012
Pharmacovigilance study of alendronate in England.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2003, Volume: 14, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Alendronate; Angioedema; Cohort Studies; Erythema Multiforme; Family

2003
No effects of bisphosphonates on the human fetus.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:3

    Topics: Alendronate; Female; Humans; Maternal Age; Maternal Exposure; Middle Aged; Osteoporosis; Pregnancy;

2003
Pregnancy-associated osteoporosis with vertebral fractures and scoliosis.
    Joint bone spine, 2004, Volume: 71, Issue:1

    Topics: Absorptiometry, Photon; Adult; Alendronate; Back Pain; Bone Density; Calcium Carbonate; Exercise The

2004
[Pregnancy-associated osteoporosis. A new case].
    La Revue de medecine interne, 2006, Volume: 27, Issue:7

    Topics: Adult; Alendronate; Bone Density; Bone Density Conservation Agents; Female; Follow-Up Studies; Fract

2006
The outcome of pregnancy following pre-pregnancy or early pregnancy alendronate treatment.
    Reproductive toxicology (Elmsford, N.Y.), 2006, Volume: 22, Issue:4

    Topics: Adult; Alendronate; Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Behcet Syndrome; Berylliosi

2006
The effect of pregnancy on pre-existing osteopenia: a case report.
    Archives of gynecology and obstetrics, 2007, Volume: 276, Issue:2

    Topics: Adult; Alendronate; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Female

2007
Effects of the bisphosphonate, alendronate, on parturition in the rat.
    Toxicology and applied pharmacology, 1993, Volume: 121, Issue:2

    Topics: Alendronate; Animals; Calcium; Diphosphonates; Female; Fertility; Hypocalcemia; Labor, Obstetric; Ma

1993
Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships.
    Bone, 1998, Volume: 23, Issue:5

    Topics: Alendronate; Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcium; Culture

1998
Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats.
    Teratology, 1999, Volume: 60, Issue:2

    Topics: Alendronate; Animals; Bone and Bones; Calcification, Physiologic; Diphosphonates; Female; Fetus; Pre

1999
Managing menopause after breast cancer: balancing risks and benefits.
    Cleveland Clinic journal of medicine, 2001, Volume: 68, Issue:3

    Topics: Adult; Alendronate; Antidepressive Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Calcit

2001
[Osteoporosis and multiple pregnancy--a case report with positive outcome].
    Medizinische Klinik (Munich, Germany : 1983), 2001, Jul-15, Volume: 96, Issue:7

    Topics: Adult; Alendronate; Bone Density; Calcium Channel Agonists; Calcium, Dietary; Cholecalciferol; Contr

2001