Page last updated: 2024-10-22

alendronate and Pericementitis

alendronate has been researched along with Pericementitis in 32 studies

alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.

Research Excerpts

ExcerptRelevanceReference
"To assess sodium alendronate as a local adjunctive therapy for treating experimental periodontitis in male rats treated with chemotherapy."8.31Sodium alendronate is an effective adjunctive therapy for treating periodontitis in male rats treated with anticancer chemotherapy. ( de Almeida, JM; Ervolino, E; Fiorin, LG; Furquim, EMA; Matheus, HR; Novaes, VCN; Oliveira, FLP; Piovezan, BR, 2023)
"The study aimed to investigate the effect of alendronate (ALN) on the inhibition of alveolar bone loss in experimental periodontitis in Wistar rats."7.83Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats. ( Crivellaro, V; Deliberador, TM; Giovanini, AF; Romito, GA; Storrer, CLM; Zielak, JC, 2016)
"This study assesses the effects of topical sodium alendronate (SA) as an adjuvant to the mechanical treatment of ligature-induced periodontitis in rats."7.81Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats. ( Bonfietti, LH; De Almeida, J; Ervolino, E; Faleiros, PL; Fernandes, LA; Garcia, VG; Martins, TM; Novaes, VC; Theodoro, LH, 2015)
"Sodium alendronate preserves alveolar bone resorption and has anti-inflammatory and antibacterial activities in experimental periodontitis."7.73Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. ( Brito, GA; Carvalho, CB; Chaves, HV; Menezes, AM; Ribeiro, RA; Rocha, FA, 2005)
"The aim of this study was to evaluate the impact of alendronate (ALD) and estrogen (EST) therapies and their withdrawal on bone loss in experimental periodontitis in ovariectomized rats."7.72Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats. ( Casati, MZ; de Assis, DR; Duarte, PM; Nociti, FH; Sallum, AW; Sallum, EA, 2004)
"Experimental periodontitis was induced by repeated injection of Escherichia coli endotoxin (LPS) and 44 adult male Sprague-Dawley rats were divided into five study groups as follows: LPS, doxycycline + LPS, alendronate + LPS, doxycycline + alendronate + LPS, and saline control."7.72Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. ( Atilla, G; Başkesen, A; Berdeli, AH; Buduneli, E; Buduneli, N; Türkoğlu, O; Vardar, S, 2004)
"This study tested the efficacy of alendronate, a bisphosphate, in reducing alveolar bone loss caused by experimental periodontitis in cynomolgus monkeys."7.69Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys. ( Aufdemorte, TB; Brunsvold, M; Chaves, E; Kornman, KS; Quartuccio, H; Rodan, GA; Seedor, JG; Weinreb, M, 1994)
"Alendronate sodium is a potent inhibitor of bone resorption which has been effectively used to control osteolysis, and to treat Paget's disease and osteoporosis."6.71The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). ( El-Shinnawi, UM; El-Tantawy, SI, 2003)
"Periodontitis was induced by ligature in 60 Wistar rats randomized into the following groups: control (Group 1); PDT (Group 2); ALN 0."5.48Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature-induced periodontitis. ( Camacho-Alonso, F; Davia-Peña, RS; Martínez-Beneyto, Y; Merino, JJ; Tudela-Mulero, MR; Vilaplana-Vivo, C, 2018)
" Superior clinical treatment outcomes were shown when alendronate, rosuvastatin, boric acid, simvastatin, and tetracycline (only at 3 months) were utilized in furcation defects in conjunction with SRP alone or SRP + placebo."5.41Local drug delivery in the treatment of furcation defects in periodontitis: a systematic review. ( Chatzopoulos, GS; Koidou, VP; Tsalikis, L, 2023)
"Alveolar bone loss was evaluated morphometrically under a stereomicroscope."5.34Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. ( Atilla, G; Buduneli, E; Buduneli, N; Sorsa, T; Vardar-Sengül, S; Wahlgren, J, 2007)
"Considering the emerging role of host-inflammatory response in treatment of periodontitis and the antiresorptive and osteostimulative properties of bisphosphonates, several studies are focusing on the role of alendronate as an addition to non-surgical periodontal therapy."5.22Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis. ( Arena, C; Caponio, VCA; Lo Muzio, L; Lo Russo, L; Troiano, G; Zhurakivska, K, 2022)
"To assess sodium alendronate as a local adjunctive therapy for treating experimental periodontitis in male rats treated with chemotherapy."4.31Sodium alendronate is an effective adjunctive therapy for treating periodontitis in male rats treated with anticancer chemotherapy. ( de Almeida, JM; Ervolino, E; Fiorin, LG; Furquim, EMA; Matheus, HR; Novaes, VCN; Oliveira, FLP; Piovezan, BR, 2023)
"The study aimed to investigate the effect of alendronate (ALN) on the inhibition of alveolar bone loss in experimental periodontitis in Wistar rats."3.83Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats. ( Crivellaro, V; Deliberador, TM; Giovanini, AF; Romito, GA; Storrer, CLM; Zielak, JC, 2016)
" Surprisingly, the bone-targeted antiresorptives bis-enoxacin and alendronate inhibited increases in oxidative stress caused by periodontitis."3.81Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives. ( Chukkapalli, SS; Holliday, LS; Kesavalu, L; Oktay, S; Rivera-Kweh, MF; Velsko, IM, 2015)
"This study assesses the effects of topical sodium alendronate (SA) as an adjuvant to the mechanical treatment of ligature-induced periodontitis in rats."3.81Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats. ( Bonfietti, LH; De Almeida, J; Ervolino, E; Faleiros, PL; Fernandes, LA; Garcia, VG; Martins, TM; Novaes, VC; Theodoro, LH, 2015)
"Sodium alendronate preserves alveolar bone resorption and has anti-inflammatory and antibacterial activities in experimental periodontitis."3.73Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. ( Brito, GA; Carvalho, CB; Chaves, HV; Menezes, AM; Ribeiro, RA; Rocha, FA, 2005)
"The aim of the present study was to evaluate the effects of systemic administration of low-dose doxycycline and a bisphosphonate, alendronate, on serum levels of interleukin-1beta (IL-1beta), osteocalcin (OC), and C-reactive protein (CRP) in experimental periodontitis in rats."3.73Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. ( Atilla, G; Buduneli, E; Buduneli, N; Kardeşler, L; Kinane, DF; Lappin, D; Vardar-Sengül, S, 2005)
"The aim of this study was to evaluate the impact of alendronate (ALD) and estrogen (EST) therapies and their withdrawal on bone loss in experimental periodontitis in ovariectomized rats."3.72Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats. ( Casati, MZ; de Assis, DR; Duarte, PM; Nociti, FH; Sallum, AW; Sallum, EA, 2004)
"Experimental periodontitis was induced by repeated injection of Escherichia coli endotoxin (LPS) and 44 adult male Sprague-Dawley rats were divided into five study groups as follows: LPS, doxycycline + LPS, alendronate + LPS, doxycycline + alendronate + LPS, and saline control."3.72Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. ( Atilla, G; Başkesen, A; Berdeli, AH; Buduneli, E; Buduneli, N; Türkoğlu, O; Vardar, S, 2004)
"This study tested the efficacy of alendronate, a bisphosphate, in reducing alveolar bone loss caused by experimental periodontitis in cynomolgus monkeys."3.69Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys. ( Aufdemorte, TB; Brunsvold, M; Chaves, E; Kornman, KS; Quartuccio, H; Rodan, GA; Seedor, JG; Weinreb, M, 1994)
"Periodontal disease is characterized by periodontal bone loss."2.73Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis. ( Cizza, G; Genco, R; Jeffcoat, MK; Lombardi, A; Shih, WJ, 2007)
"Alendronate sodium is a potent inhibitor of bone resorption which has been effectively used to control osteolysis, and to treat Paget's disease and osteoporosis."2.71The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). ( El-Shinnawi, UM; El-Tantawy, SI, 2003)
"Alendronate (ALN) is an aminobisphosphonate commonly used for osteoporosis in postmenopausal women."2.70Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial. ( Garay-Sevilla, ME; Malacara, JM; Nava, LE; Rocha, M; Sánchez-Márin, F; Vázquez de la Torre, C, 2001)
"Because the severity of alveolar bone loss increases with age, it has long been hypothesized that it may, in part, be related to systemic conditions that also predispose the patient to osteoporosis/osteopenia."2.40Osteoporosis: a possible modifying factor in oral bone loss. ( Jeffcoat, MK, 1998)
"Periodontitis was induced by ligature in 60 Wistar rats randomized into the following groups: control (Group 1); PDT (Group 2); ALN 0."1.48Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature-induced periodontitis. ( Camacho-Alonso, F; Davia-Peña, RS; Martínez-Beneyto, Y; Merino, JJ; Tudela-Mulero, MR; Vilaplana-Vivo, C, 2018)
"Periodontitis was induced by ligature around the upper second molar in 36 male Wistar rats (± 200 g)."1.38Effect of alendronate on bone-specific alkaline phosphatase on periodontal bone loss in rats. ( Dutra, CS; Goes, P; Lima, AP; Lima, V; Melo, IM, 2012)
"Pretreatment with alendronate augmented IL-1beta, but not TNFalpha, production by macrophages infected with P."1.35Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1. ( Deng, X; Endo, Y; Kiyoura, Y; Tamai, R, 2009)
"Alveolar bone loss was evaluated morphometrically under a stereomicroscope."1.34Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. ( Atilla, G; Buduneli, E; Buduneli, N; Sorsa, T; Vardar-Sengül, S; Wahlgren, J, 2007)
"Sixty-two (52."1.33Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment. ( Broumand, V; Fortin, M; Marx, RE; Sawatari, Y, 2005)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (12.50)18.2507
2000's14 (43.75)29.6817
2010's11 (34.38)24.3611
2020's3 (9.38)2.80

Authors

AuthorsStudies
Arena, C1
Caponio, VCA1
Zhurakivska, K1
Lo Russo, L1
Lo Muzio, L1
Troiano, G1
Chatzopoulos, GS1
Koidou, VP1
Tsalikis, L1
Oliveira, FLP1
Matheus, HR1
Ervolino, E2
Novaes, VCN1
Piovezan, BR1
Furquim, EMA1
Fiorin, LG1
de Almeida, JM1
Camacho-Alonso, F1
Davia-Peña, RS1
Vilaplana-Vivo, C1
Tudela-Mulero, MR1
Merino, JJ1
Martínez-Beneyto, Y1
Carvalho Dutra, B1
Oliveira, AMSD1
Oliveira, PAD1
Miranda Cota, LO1
Silveira, JO1
Costa, FO1
Oktay, S1
Chukkapalli, SS1
Rivera-Kweh, MF1
Velsko, IM1
Holliday, LS1
Kesavalu, L2
Moreira, MM1
Bradaschia-Correa, V1
Marques, ND1
Ferreira, LB1
Arana-Chavez, VE1
De Almeida, J1
Bonfietti, LH1
Novaes, VC1
Theodoro, LH1
Fernandes, LA1
Martins, TM1
Faleiros, PL1
Garcia, VG1
Storrer, CLM1
Deliberador, TM1
Giovanini, AF1
Crivellaro, V1
Zielak, JC1
Romito, GA1
Deng, X1
Tamai, R1
Endo, Y1
Kiyoura, Y1
Grey, A1
Aguirre, JI1
Akhter, MP1
Kimmel, DB1
Pingel, JE1
Williams, A1
Jorgensen, M1
Wronski, TJ1
Goes, P1
Melo, IM1
Dutra, CS1
Lima, AP1
Lima, V1
Price, U1
Le, HO1
Powell, SE1
Schmid, MJ1
Marx, DB1
Zhang, Y1
Wang, D1
Narayana, N1
Reinhardt, RA1
Hasegawa, T1
Ri, S1
Umeda, M1
Komatsubara, H1
Kobayashi, M1
Shigeta, T1
Yoshitomi, I1
Ikeda, H1
Shibuya, Y1
Asahina, I1
Komori, T1
Tenenbaum, HC1
Shelemay, A1
Girard, B1
Zohar, R1
Fritz, PC1
El-Shinnawi, UM1
El-Tantawy, SI1
Duarte, PM1
de Assis, DR1
Casati, MZ1
Sallum, AW1
Sallum, EA1
Nociti, FH1
Buduneli, E3
Vardar, S1
Buduneli, N3
Berdeli, AH1
Türkoğlu, O1
Başkesen, A1
Atilla, G3
Lane, N1
Armitage, GC1
Loomer, P1
Hsieh, S1
Majumdar, S1
Wang, HY1
Jeffcoat, M1
Munoz, T1
Marx, RE1
Sawatari, Y1
Fortin, M1
Broumand, V1
Menezes, AM1
Rocha, FA1
Chaves, HV1
Carvalho, CB1
Ribeiro, RA1
Brito, GA1
Vardar-Sengül, S2
Kardeşler, L1
Lappin, D1
Kinane, DF1
Wahlgren, J1
Sorsa, T1
Jeffcoat, MK3
Cizza, G1
Shih, WJ1
Genco, R1
Lombardi, A1
Xiong, H1
Peng, B1
Wei, L1
Zhang, X1
Wang, L1
Reddy, MS1
Weatherford, TW1
Smith, CA1
West, BD1
Jacks, TM1
Weinreb, M1
Quartuccio, H1
Seedor, JG1
Aufdemorte, TB2
Brunsvold, M1
Chaves, E1
Kornman, KS2
Rodan, GA1
Rocha, M1
Nava, LE1
Vázquez de la Torre, C1
Sánchez-Márin, F1
Garay-Sevilla, ME1
Malacara, JM1
Ciancio, SG1
Brunsvold, MA1
Chaves, ES1
Wood, R1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Investigation of the Effects of Bisphosphonate on the Gingival Crevicular Fluid Levels of Sclerostin and the DKK-1 in Individuals With Postmenopausal Osteoporosis With Periodontal Changes[NCT04149405]Phase 443 participants (Actual)Interventional2016-06-30Completed
Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study[NCT02808988]Phase 447 participants (Actual)Interventional2013-10-31Completed
The Effect of Orally Administered Bisphosphonates in the Treatment of Osteoporosis on the Alveolar Bone Using Panoramic and Cone-Beam CT Imaging: A Case-control Study[NCT02115490]60 participants (Actual)Observational2014-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dkk-1 Values for 12th Month

levels of dickkopf-related protein-1 in 12th month (NCT04149405)
Timeframe: 12 months

Interventionng/ml (Mean)
Group A3440.67
Group B3203.802
Group C2490.553
Group D4269.39

Dkk-1 Values for 6th Month

levels of dickkopf-related protein-1 in 6th month (NCT04149405)
Timeframe: 6 months

Interventionng/ml (Mean)
Group A3358.265
Group B1963.185
Group C3263.665
Group D4269.39

Sost Values for 12th Month

levels of sclerostin in 12th month (NCT04149405)
Timeframe: 12 month

Interventionng/ml (Mean)
Group A1702.265
Group B1347.330
Group C1114.988
Group D2131.87

Sost Values for 6th Month

levels of sclerostin in 6th month (NCT04149405)
Timeframe: 6 months

Interventionng/ml (Mean)
Group A1389.177
Group B1085.405
Group C1596.585
Group D2131.87

Reviews

5 reviews available for alendronate and Pericementitis

ArticleYear
Added effect of 1% topical alendronate in intra-bony and inter-radicular defects as part of step II periodontal therapy: a systematic review with meta-analysis and trial sequential analysis.
    BMC oral health, 2022, 01-21, Volume: 22, Issue:1

    Topics: Alendronate; Alveolar Bone Loss; Diphosphonates; Humans; Periodontal Attachment Loss; Periodontitis

2022
Local drug delivery in the treatment of furcation defects in periodontitis: a systematic review.
    Clinical oral investigations, 2023, Volume: 27, Issue:3

    Topics: Alendronate; Dental Scaling; Furcation Defects; Humans; Periodontitis; Root Planing; Rosuvastatin Ca

2023
Bisphosphonates and periodontics: potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses.
    Journal of periodontology, 2002, Volume: 73, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Bone Regeneration; Diphosphonates; Etidronic

2002
Osteoporosis: a possible modifying factor in oral bone loss.
    Annals of periodontology, 1998, Volume: 3, Issue:1

    Topics: Alendronate; Alveolar Bone Loss; Bone Density; Estrogen Replacement Therapy; Female; Humans; Male; M

1998
Systemic medications: clinical significance in periodontics.
    Journal of clinical periodontology, 2002, Volume: 29 Suppl 2

    Topics: Alendronate; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroida

2002

Trials

5 trials available for alendronate and Pericementitis

ArticleYear
Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: A 6-month randomized controlled clinical trial.
    Journal of periodontology, 2019, Volume: 90, Issue:10

    Topics: Alendronate; Alveolar Bone Loss; Follow-Up Studies; Guided Tissue Regeneration, Periodontal; Humans;

2019
The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial).
    Journal of the International Academy of Periodontology, 2003, Volume: 5, Issue:1

    Topics: Absorptiometry, Photon; Adult; Alendronate; Alveolar Bone Loss; Alveolar Process; Bone Density; Dent

2003
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis.
    Journal of the International Academy of Periodontology, 2007, Volume: 9, Issue:3

    Topics: Adult; Aged; Alendronate; Alveolar Bone Loss; Alveolar Process; Analysis of Variance; Bone Density;

2007
Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial.
    Journal of periodontology, 2001, Volume: 72, Issue:2

    Topics: Alendronate; Alveolar Bone Loss; Alveolar Process; Biomarkers; Bone Resorption; Case-Control Studies

2001

Other Studies

22 other studies available for alendronate and Pericementitis

ArticleYear
Sodium alendronate is an effective adjunctive therapy for treating periodontitis in male rats treated with anticancer chemotherapy.
    Archives of oral biology, 2023, Volume: 155

    Topics: Alendronate; Alveolar Bone Loss; Animals; Dental Scaling; Fluorouracil; Male; Osteocalcin; Periodont

2023
Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature-induced periodontitis.
    Journal of periodontal research, 2018, Volume: 53, Issue:3

    Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Disease Models, Animal; Drug Combinations; D

2018
Periodontitis in rats induces systemic oxidative stress that is controlled by bone-targeted antiresorptives.
    Journal of periodontology, 2015, Volume: 86, Issue:1

    Topics: Alendronate; Animals; Anti-Bacterial Agents; Antioxidants; Bacteroidaceae Infections; Bacteroides In

2015
Ultrastructural and immunohistochemical study of the effect of sodium alendronate in the progression of experimental periodontitis in rats.
    Microscopy research and technique, 2014, Volume: 77, Issue:11

    Topics: Alendronate; Alveolar Process; Animals; Dental Papilla; Disease Progression; Gingiva; Male; Microsco

2014
Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats.
    Journal of periodontology, 2015, Volume: 86, Issue:10

    Topics: Alendronate; Alveolar Process; Animals; Apoptosis; Bone Density Conservation Agents; Caspase 3; Comb

2015
Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats.
    Clinical oral investigations, 2016, Volume: 20, Issue:9

    Topics: Alendronate; Alveolar Bone Loss; Animals; Disease Progression; Fusobacterium nucleatum; Male; Period

2016
Alendronate augments interleukin-1beta release from macrophages infected with periodontal pathogenic bacteria through activation of caspase-1.
    Toxicology and applied pharmacology, 2009, Feb-15, Volume: 235, Issue:1

    Topics: Alendronate; Animals; Bacteroidaceae; Bone Density Conservation Agents; Caspase 1; Clodronic Acid; D

2009
Teriparatide for bone loss in the jaw.
    The New England journal of medicine, 2010, Dec-16, Volume: 363, Issue:25

    Topics: Alendronate; Bone Density Conservation Agents; Bone Regeneration; Combined Modality Therapy; Humans;

2010
Oncologic doses of zoledronic acid induce osteonecrosis of the jaw-like lesions in rice rats (Oryzomys palustris) with periodontitis.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2012, Volume: 27, Issue:10

    Topics: Alendronate; Animals; Apoptosis; Bisphosphonate-Associated Osteonecrosis of the Jaw; Cell Count; Dip

2012
Effect of alendronate on bone-specific alkaline phosphatase on periodontal bone loss in rats.
    Archives of oral biology, 2012, Volume: 57, Issue:11

    Topics: Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Alveolar Process; Analysis of Variance; Anima

2012
Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss.
    Journal of periodontal research, 2013, Volume: 48, Issue:5

    Topics: Alendronate; Alveolar Bone Loss; Animals; beta-Cyclodextrins; Bone Density Conservation Agents; Drug

2013
The observational study of delayed wound healing after tooth extraction in patients receiving oral bisphosphonate therapy.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2013, Volume: 41, Issue:7

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alendronate; Antibiotic Prophylaxis; Bisphosph

2013
Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats.
    Journal of periodontology, 2004, Volume: 75, Issue:9

    Topics: Alendronate; Alkaline Phosphatase; Alveolar Bone Loss; Alveolar Process; Animals; Dental Plaque Inde

2004
Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats.
    Journal of periodontology, 2004, Volume: 75, Issue:11

    Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Dinoprost; Dinoprostone; Doxycyclin

2004
Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: risk factors, recognition, prevention, and treatment.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2005, Volume: 63, Issue:11

    Topics: Abscess; Alendronate; Antineoplastic Agents; Bone Density Conservation Agents; Bone Neoplasms; Breas

2005
Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats.
    Journal of periodontology, 2005, Volume: 76, Issue:11

    Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Bone Dens

2005
Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats.
    Journal of periodontology, 2005, Volume: 76, Issue:11

    Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Bone Density Conservation Agents; C

2005
Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate.
    Journal of periodontology, 2007, Volume: 78, Issue:1

    Topics: Alendronate; Alveolar Bone Loss; Animals; Anti-Bacterial Agents; Bone Density Conservation Agents; C

2007
Effect of an estrogen-deficient state and alendronate therapy on bone loss resulting from experimental periapical lesions in rats.
    Journal of endodontics, 2007, Volume: 33, Issue:11

    Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density Conservation Agents; Estrogens; Female; Injec

2007
Alendronate treatment of naturally-occurring periodontitis in beagle dogs.
    Journal of periodontology, 1995, Volume: 66, Issue:3

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Animals; Diphosphonates; Disease Models, Anim

1995
Histomorphometrical analysis of the effects of the bisphosphonate alendronate on bone loss caused by experimental periodontitis in monkeys.
    Journal of periodontal research, 1994, Volume: 29, Issue:1

    Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Diphosphonates; Macaca fascicularis; Mandibu

1994
Effects of a bisphosphonate on experimental periodontitis in monkeys.
    Journal of periodontology, 1992, Volume: 63, Issue:10

    Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Dental Plaque Index; Diphosphonates; Macaca

1992