alendronate has been researched along with Peptic Ulcer in 4 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Clinical trials often underestimate the rate of adverse events in clinical practice, and ethics prohibit direct evaluation of toxicity in high-risk patients." | 2.41 | The gastrointestinal tolerability and safety of oral bisphosphonates. ( Marshall, JK, 2002) |
| "Alendronate is an antiosteolytic agent under investigation for the treatment of a number of bone disorders." | 1.29 | On the absorption of alendronate in rats. ( Chen, IW; deLuna, FA; Lin, JH, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marshall, JK | 2 |
| Thabane, M | 1 |
| James, C | 1 |
| Lin, JH | 1 |
| Chen, IW | 1 |
| deLuna, FA | 1 |
| Bauer, DC | 1 |
1 review available for alendronate and Peptic Ulcer
| Article | Year |
|---|---|
The gastrointestinal tolerability and safety of oral bisphosphonates.
Topics: Administration, Oral; Alendronate; Biological Availability; Clinical Trials as Topic; Diphosphonates | 2002 |
1 trial available for alendronate and Peptic Ulcer
| Article | Year |
|---|---|
Randomized active and placebo-controlled endoscopy study of a novel protected formulation of oral alendronate.
Topics: Administration, Oral; Alendronate; Bone Density Conservation Agents; Endoscopy; Esophagus; Female; H | 2006 |
2 other studies available for alendronate and Peptic Ulcer
| Article | Year |
|---|---|
On the absorption of alendronate in rats.
Topics: Administration, Oral; Alendronate; Animals; Bone and Bones; Carbon Radioisotopes; Digestive System; | 1994 |
Alendronate and nonsteroidal anti-inflammatory drug interaction safety is not established: a reply.
Topics: Alendronate; Anti-Inflammatory Agents, Non-Steroidal; Drug Synergism; Fractures, Bone; Humans; Pepti | 2000 |