alendronate has been researched along with Pancreatic Neoplasms in 3 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we have characterized the cytotoxic reactivity of gammadelta T cell lines established from healthy donors by stimulation with aminobisphosphonate alendronate toward melanoma MeWo and pancreatic adenocarcinomas Colo357 and PancTu1 lines in vitro and in vivo upon adoptive transfer into SCID mice." | 3.72 | Characterization of tumor reactivity of human V gamma 9V delta 2 gamma delta T cells in vitro and in SCID mice in vivo. ( Kabelitz, D; Pitters, E; Wesch, D; Zöller, M, 2004) |
| "Hypercalcemia was treated with an investigational aminobisphosphonate." | 1.28 | Parathyroid hormone-related peptide mediates hypercalcemia in an islet cell tumor of the pancreas. ( Hutchison, JS; Kaufman, SD; Mitlak, BH; Nussbaum, SR, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kawashiri, T | 1 |
| Tokunaga, A | 1 |
| Kobayashi, D | 1 |
| Shimazoe, T | 1 |
| Kabelitz, D | 1 |
| Wesch, D | 1 |
| Pitters, E | 1 |
| Zöller, M | 1 |
| Mitlak, BH | 1 |
| Hutchison, JS | 1 |
| Kaufman, SD | 1 |
| Nussbaum, SR | 1 |
3 other studies available for alendronate and Pancreatic Neoplasms
| Article | Year |
|---|---|
Anti-tumor Activities of 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors and Bisphosphonates in Pancreatic Cell Lines Which Show Poor Responses to Gemcitabine.
Topics: Alendronate; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Deoxycytidine; Gemcitabine; Hum | 2020 |
Characterization of tumor reactivity of human V gamma 9V delta 2 gamma delta T cells in vitro and in SCID mice in vivo.
Topics: Adenocarcinoma; Adoptive Transfer; Adult; Alendronate; Animals; Cell Line; Cell Line, Tumor; Cell Pr | 2004 |
Parathyroid hormone-related peptide mediates hypercalcemia in an islet cell tumor of the pancreas.
Topics: Adenoma, Islet Cell; Aged; Alendronate; Cyclic AMP; Diphosphonates; Female; Humans; Hypercalcemia; P | 1991 |