alendronate has been researched along with Otosclerosis in 3 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Identify and compare phenotypic properties of osteoblasts from patients with otosclerosis (OSO), normal bones (HOB), and normal stapes (NSO) to determine a possible cause for OSO hypermineralization and assess any effects of the bisphosphonate, alendronate." | 3.80 | Differences in otosclerotic and normal human stapedial osteoblast properties are normalized by alendronate in vitro. ( Aronow, M; Eisen, M; Flynn, J; Gronowicz, G; Kveton, J; Leonard, G; Parham, K; Richardson, YL; Rodner, C, 2014) |
| "Otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to a progressive hearing loss." | 2.77 | The effectiveness of audiometric evaluation in drug treatment for otospongiosis. ( Cruz, OL; Penido, Nde O; Suzuki, FB; Vicente, Ade O; Yamashita, HK, 2012) |
| "Otosclerosis is a bony dyscrasia characterized by histopathological findings of osteoclast production." | 1.35 | Medical treatment of otosclerosis: rationale for use of bisphosphonates. ( Brookler, K, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gronowicz, G | 1 |
| Richardson, YL | 1 |
| Flynn, J | 1 |
| Kveton, J | 1 |
| Eisen, M | 1 |
| Leonard, G | 1 |
| Aronow, M | 1 |
| Rodner, C | 1 |
| Parham, K | 1 |
| Brookler, K | 1 |
| Vicente, Ade O | 1 |
| Yamashita, HK | 1 |
| Cruz, OL | 1 |
| Suzuki, FB | 1 |
| Penido, Nde O | 1 |
1 trial available for alendronate and Otosclerosis
| Article | Year |
|---|---|
The effectiveness of audiometric evaluation in drug treatment for otospongiosis.
Topics: Adult; Aged; Alendronate; Audiometry; Auditory Threshold; Bone Conduction; Bone Density Conservation | 2012 |
2 other studies available for alendronate and Otosclerosis
| Article | Year |
|---|---|
Differences in otosclerotic and normal human stapedial osteoblast properties are normalized by alendronate in vitro.
Topics: Adult; Alendronate; Bone Density Conservation Agents; Calcification, Physiologic; Case-Control Studi | 2014 |
Medical treatment of otosclerosis: rationale for use of bisphosphonates.
Topics: Aged; Alendronate; Animals; Bone Density Conservation Agents; Bone Resorption; Cell Death; Combined | 2008 |