Page last updated: 2024-10-22

alendronate and Osteomyelitis

alendronate has been researched along with Osteomyelitis in 15 studies

alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.

Osteomyelitis: INFLAMMATION of the bone as a result of infection. It may be caused by a variety of infectious agents, especially pyogenic (PUS - producing) BACTERIA.

Research Excerpts

ExcerptRelevanceReference
" Our aims were to evaluate if the risk of surgically treated ONJ increases with longer or more compliant treatment with alendronate for osteoporosis and to identify risk factors for surgically treated ONJ."7.85Surgically treated osteonecrosis and osteomyelitis of the jaw and oral cavity in patients highly adherent to alendronate treatment: a nationwide user-only cohort study including over 60,000 alendronate users. ( Abrahamsen, B; Eastell, R; Eiken, PA; Prieto-Alhambra, D, 2017)
"The aim of this study was to evaluate a possible role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (ONJ) and to discuss an etiological model."7.76Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings. ( Eufinger, H; Hoefert, S; Schmitz, I; Tannapfel, A, 2010)
"We report a case of diffuse sclerosing osteomyelitis of the mandible responded to alendronate, after a poor response to intravenous antibiotics, antibiotic irrigation-perfusion, and decortication."7.73Response of diffuse sclerosing osteomyelitis of the mandible to alendronate: follow-up study by 99mTc scintigraphy. ( Hamakawa, H; Hino, S; Murase, R; Shintani, S; Terakado, N, 2005)
"Osteomyelitis is a progressive destruction of bones caused by microorganisms."5.42Alendronate-coated long-circulating liposomes containing 99mtechnetium-ceftizoxime used to identify osteomyelitis. ( Boratto, FA; Cardoso, VN; Fernandes, SO; Ferreira, Ddos S; Ferreira, LA; Oliveira, MC; Serakides, R, 2015)
"Tibial osteomyelitis was induced in 72 Wistar albino rats with Staphylococcus aureus ATCC 25923 strain."5.35Alendronate enhances antibiotic-impregnated bone grafts in the treatment of osteomyelitis. ( Aktekin, CN; Altay, M; Erdemli, E; Karahuseyinoglu, S; Korkusuz, F; Ozturk, AM; Tabak, AY, 2008)
" Here, we show that administration of anti-resorptive agents such as the bisphosphonate alendronate accelerates osteonecrosis promoted by infectious osteomyelitis."3.85Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis. ( Ishihara, K; Ishii, K; Iwakura, Y; Iwasaki, R; Kawana, H; Keneko, Y; Kobayashi, T; Matsumoto, M; Miyamoto, K; Miyamoto, T; Morita, M; Nakagawa, T; Nakamura, M; Nakamura, S; Oike, T; Sato, Y; Watanabe, R, 2017)
" Our aims were to evaluate if the risk of surgically treated ONJ increases with longer or more compliant treatment with alendronate for osteoporosis and to identify risk factors for surgically treated ONJ."3.85Surgically treated osteonecrosis and osteomyelitis of the jaw and oral cavity in patients highly adherent to alendronate treatment: a nationwide user-only cohort study including over 60,000 alendronate users. ( Abrahamsen, B; Eastell, R; Eiken, PA; Prieto-Alhambra, D, 2017)
"The aim of this study was to evaluate a possible role of microcracks in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (ONJ) and to discuss an etiological model."3.76Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings. ( Eufinger, H; Hoefert, S; Schmitz, I; Tannapfel, A, 2010)
"We report a case of diffuse sclerosing osteomyelitis of the mandible responded to alendronate, after a poor response to intravenous antibiotics, antibiotic irrigation-perfusion, and decortication."3.73Response of diffuse sclerosing osteomyelitis of the mandible to alendronate: follow-up study by 99mTc scintigraphy. ( Hamakawa, H; Hino, S; Murase, R; Shintani, S; Terakado, N, 2005)
"She had been treated for postmenopausal osteoporosis with 70 mg of alendronate weekly for 2 years."1.91A Case Report of Oral Bisphosphonate Treatment for Osteoporosis Leading to Atypical Femoral Fracture and Pathologic Mandibular Fracture. ( Fernandes, TL; Franco, GCN; Jitumori, C; Viezzer Fernandes, B, 2023)
"Tibial osteomyelitis was induced in 72 Wistar albino rats with Staphylococcus aureus ATCC 25923 strain."1.35Alendronate enhances antibiotic-impregnated bone grafts in the treatment of osteomyelitis. ( Aktekin, CN; Altay, M; Erdemli, E; Karahuseyinoglu, S; Korkusuz, F; Ozturk, AM; Tabak, AY, 2008)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (20.00)29.6817
2010's9 (60.00)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Fernandes, TL1
Viezzer Fernandes, B1
Jitumori, C1
Franco, GCN1
Yang, X1
Zhou, K1
Shang, W1
Song, K1
Kamble, S1
Valtchev, P1
Dao, A1
Pelras, T1
Rogers, MJ1
Savage, PB1
Dehghani, F1
Schindeler, A1
Morita, M1
Iwasaki, R1
Sato, Y1
Kobayashi, T1
Watanabe, R1
Oike, T1
Nakamura, S1
Keneko, Y1
Miyamoto, K1
Ishihara, K1
Iwakura, Y1
Ishii, K1
Matsumoto, M1
Nakamura, M1
Kawana, H1
Nakagawa, T1
Miyamoto, T1
Hirano, D1
Chiba, K1
Yamada, S1
Ida, H1
Eiken, PA1
Prieto-Alhambra, D1
Eastell, R1
Abrahamsen, B1
Ferreira, Ddos S1
Boratto, FA1
Cardoso, VN1
Serakides, R1
Fernandes, SO1
Ferreira, LA1
Oliveira, MC1
Hoefert, S1
Schmitz, I1
Tannapfel, A1
Eufinger, H1
Pazianas, M1
Vestergaard, P1
Schwartz, K1
Rejnmark, L1
Mosekilde, L1
Pinholt, EM1
Bartl, R1
Jacobsen, C1
Metzler, P1
Rössle, M1
Obwegeser, J1
Zemann, W1
Grätz, KW1
Chun, CS1
Hino, S1
Murase, R1
Terakado, N1
Shintani, S1
Hamakawa, H1
Ozturk, AM1
Tabak, AY1
Aktekin, CN1
Altay, M1
Erdemli, E1
Karahuseyinoglu, S1
Korkusuz, F1

Reviews

2 reviews available for alendronate and Osteomyelitis

ArticleYear
Osteonecrosis of the jaw and the role of macrophages.
    Journal of the National Cancer Institute, 2011, Feb-02, Volume: 103, Issue:3

    Topics: Alendronate; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bone

2011
Chronic recurrent multifocal osteomyelitis of the spine and mandible: case report and review of the literature.
    Pediatrics, 2004, Volume: 113, Issue:4

    Topics: Alendronate; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Chron

2004

Other Studies

13 other studies available for alendronate and Osteomyelitis

ArticleYear
A Case Report of Oral Bisphosphonate Treatment for Osteoporosis Leading to Atypical Femoral Fracture and Pathologic Mandibular Fracture.
    The American journal of case reports, 2023, Oct-23, Volume: 24

    Topics: Alendronate; Bone Density Conservation Agents; Diphosphonates; Female; Femoral Fractures; Fractures,

2023
Oral administration of alendronate and vitamin D3 for the treatment of chronic non-bacterial osteomyelitis of the jaw.
    International journal of oral and maxillofacial surgery, 2020, Volume: 49, Issue:12

    Topics: Administration, Oral; Alendronate; Child, Preschool; Cholecalciferol; Female; Humans; Mandible; Oste

2020
Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications.
    Molecules (Basel, Switzerland), 2021, Mar-11, Volume: 26, Issue:6

    Topics: 3T3 Cells; Alendronate; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Bone and Bones; Calci

2021
Elevation of pro-inflammatory cytokine levels following anti-resorptive drug treatment is required for osteonecrosis development in infectious osteomyelitis.
    Scientific reports, 2017, 04-07, Volume: 7

    Topics: Alendronate; Animals; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bone Density Conservation

2017
Oral alendronate in pediatric chronic recurrent multifocal osteomyelitis.
    Pediatrics international : official journal of the Japan Pediatric Society, 2017, Volume: 59, Issue:4

    Topics: Administration, Oral; Adolescent; Alendronate; Bone Density Conservation Agents; Female; Humans; Ost

2017
Surgically treated osteonecrosis and osteomyelitis of the jaw and oral cavity in patients highly adherent to alendronate treatment: a nationwide user-only cohort study including over 60,000 alendronate users.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017, Volume: 28, Issue:10

    Topics: Administration, Oral; Aged; Aged, 80 and over; Alendronate; Bisphosphonate-Associated Osteonecrosis

2017
Alendronate-coated long-circulating liposomes containing 99mtechnetium-ceftizoxime used to identify osteomyelitis.
    International journal of nanomedicine, 2015, Volume: 10

    Topics: Alendronate; Animals; Ceftizoxime; Liposomes; Organotechnetium Compounds; Osteomyelitis; Rats; Rats,

2015
Importance of microcracks in etiology of bisphosphonate-related osteonecrosis of the jaw: a possible pathogenetic model of symptomatic and non-symptomatic osteonecrosis of the jaw based on scanning electron microscopy findings.
    Clinical oral investigations, 2010, Volume: 14, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Alendronate; Bone Density Conservation Agents; Connective Tissue; Di

2010
Oral bisphosphonate use increases the risk for inflammatory jaw disease: a cohort study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:4

    Topics: Administration, Oral; Aged; Alcoholism; Alendronate; Bisphosphonate-Associated Osteonecrosis of the

2012
[Inflammation of the jaws during treatment with bisphosphonates].
    Deutsche medizinische Wochenschrift (1946), 2011, Volume: 136, Issue:41

    Topics: Administration, Oral; Aged; Alendronate; Bone Density; Bone Density Conservation Agents; Bone Diseas

2011
Osteopathology induced by bisphosphonates and dental implants: clinical observations.
    Clinical oral investigations, 2013, Volume: 17, Issue:1

    Topics: Actinomycosis; Administration, Intravenous; Administration, Oral; Alendronate; Anti-Bacterial Agents

2013
Response of diffuse sclerosing osteomyelitis of the mandible to alendronate: follow-up study by 99mTc scintigraphy.
    International journal of oral and maxillofacial surgery, 2005, Volume: 34, Issue:5

    Topics: Adult; Alendronate; Facial Pain; Follow-Up Studies; Humans; Infusions, Intravenous; Mandible; Mandib

2005
Alendronate enhances antibiotic-impregnated bone grafts in the treatment of osteomyelitis.
    International orthopaedics, 2008, Volume: 32, Issue:6

    Topics: Alendronate; Animals; Anti-Bacterial Agents; Bone Density Conservation Agents; Bone Transplantation;

2008