alendronate has been researched along with Osteoarthritis in 23 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA)." | 8.88 | [Research progress of protective effects of alendronate on articular cartilage in osteoarthritis]. ( He, D; Luo, Y; Wei, Q; Yin, M, 2012) |
| "This study aimed to evaluate the effects of intra-articular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis." | 8.31 | Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis. ( Acibadem, E; Bozdag, Z; Keskinruzgar, A; Yavuz, GY, 2023) |
| "To employ elemental Strontium as a tracer of bone turnover, in the presence (or absence) of the bisphosphonate drug Alendronate, in order to spatially map osteophytogenesis and other bone turnover in rats developing post-traumatic secondary osteoarthritis (PTOA)." | 7.78 | Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. ( Doschak, MR; Maksymowych, WP; Panahifar, A, 2012) |
| "To evaluate the effects of alendronate (ALN) on the subchondral bone quality and cartilage degeneration in the early phase of experimental model of osteoarthritis after anterior cruciate ligament transaction (ACLT)." | 7.77 | Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis. ( Hu, H; Song, H; Tian, F; Zhang, L; Zhang, Y, 2011) |
| "Alendronate (ALN) is a potent inhibitor of osteoclastic bone resorption and results in reduced bone remodeling." | 5.40 | Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression. ( de Blois, E; de Jong, M; Groen, HC; Koelewijn, SJ; Müller, C; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2014) |
| "To summarize the recent development on chondroprotective effect of alendronate (ALN) on articular cartilage in osteoarthritis (OA)." | 4.88 | [Research progress of protective effects of alendronate on articular cartilage in osteoarthritis]. ( He, D; Luo, Y; Wei, Q; Yin, M, 2012) |
| "This study aimed to evaluate the effects of intra-articular injection of alendronate to osteoarthritis, which has a protective effect on bone and cartilage tissue and helps reduce inflammation in temporomandibular joint osteoarthritis." | 4.31 | Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis. ( Acibadem, E; Bozdag, Z; Keskinruzgar, A; Yavuz, GY, 2023) |
| "Mechanical loading and alendronate (ALN) can be used as noninvasive physical therapy methods for osteoarthritis (OA)." | 4.31 | Axial Compressive Loading Attenuates Early Osteoarthritis by Reducing Subchondral Bone Remodeling. ( Cai, H; Fu, L; Li, G; Liu, C; Liu, Q; Liu, Y; Pan, Y; Wu, J; Yang, Q; Yu, Y; Zhong, J, 2023) |
| "To investigate the disease modifying effects of cathepsin K (CatK) inhibitor L-006235 compared to alendronate (ALN) in two preclinical models of osteoarthritis (OA)." | 3.78 | Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis. ( Duong, LT; Hayami, T; Pickarski, M; Wesolowski, GA; Zhuo, Y, 2012) |
| "To employ elemental Strontium as a tracer of bone turnover, in the presence (or absence) of the bisphosphonate drug Alendronate, in order to spatially map osteophytogenesis and other bone turnover in rats developing post-traumatic secondary osteoarthritis (PTOA)." | 3.78 | Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. ( Doschak, MR; Maksymowych, WP; Panahifar, A, 2012) |
| "To evaluate the effects of alendronate (ALN) on the subchondral bone quality and cartilage degeneration in the early phase of experimental model of osteoarthritis after anterior cruciate ligament transaction (ACLT)." | 3.77 | Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis. ( Hu, H; Song, H; Tian, F; Zhang, L; Zhang, Y, 2011) |
| "To examine the effects of alendronate (ALN) on IL-1beta-stimulated chondrocyte of rabbit in vitro and on cartilage and subchondral bone in rabbit osteoarthritis (OA) induced by anterior cruciate ligament transection (ACLT)." | 3.75 | [In vitro effect of alendronate on chondrocytes and articular cartilage and subchondral bone in rabbit anterior cruciate ligament transection model]. ( Cheng, T; Hu, H; Li, B; Liu, X; Tian, F; Wang, Z; Zhang, L; Zhang, Y, 2009) |
| "Alendronate (ALN) is a potent inhibitor of osteoclastic bone resorption and results in reduced bone remodeling." | 1.40 | Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression. ( de Blois, E; de Jong, M; Groen, HC; Koelewijn, SJ; Müller, C; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 13 (56.52) | 24.3611 |
| 2020's | 6 (26.09) | 2.80 |
| Authors | Studies |
|---|---|
| Acibadem, E | 3 |
| Keskinruzgar, A | 3 |
| Bozdag, Z | 3 |
| Yavuz, GY | 3 |
| Wu, J | 1 |
| Pan, Y | 1 |
| Yu, Y | 1 |
| Yang, Q | 1 |
| Liu, Q | 1 |
| Liu, Y | 1 |
| Zhong, J | 1 |
| Fu, L | 1 |
| Cai, H | 1 |
| Liu, C | 1 |
| Li, G | 1 |
| Lambova, SN | 1 |
| Ivanovska, N | 1 |
| Stoyanova, S | 1 |
| Belenska-Todorova, L | 1 |
| Georgieva, E | 1 |
| Batsalova, T | 1 |
| Moten, D | 1 |
| Apostolova, D | 1 |
| Dzhambazov, B | 1 |
| Scanu, A | 1 |
| Luisetto, R | 1 |
| Pavan, M | 1 |
| Guarise, C | 1 |
| Beninatto, R | 1 |
| Giraudo, C | 1 |
| Galuppini, F | 1 |
| Lazzarin, V | 1 |
| Guzzardo, V | 1 |
| Pennelli, G | 1 |
| Galesso, D | 1 |
| Masiero, S | 1 |
| Wu, H | 1 |
| Xu, T | 1 |
| Chen, Z | 1 |
| Wang, Y | 1 |
| Li, K | 1 |
| Chen, PS | 1 |
| Yao, Z | 1 |
| Su, J | 1 |
| Cheng, C | 1 |
| Wu, X | 1 |
| Zhang, H | 1 |
| Chai, Y | 1 |
| Zhang, X | 1 |
| Hu, Y | 1 |
| Yu, B | 2 |
| Cui, Z | 2 |
| Ziemian, SN | 1 |
| Witkowski, AM | 1 |
| Wright, TM | 1 |
| Otero, M | 1 |
| van der Meulen, MCH | 1 |
| Zhang, N | 2 |
| Tian, F | 3 |
| Gou, Y | 1 |
| Chen, T | 1 |
| Kong, Q | 1 |
| Lv, Q | 1 |
| Li, H | 1 |
| Zhang, L | 3 |
| Panahifar, A | 2 |
| Mahmoudi, M | 1 |
| Doschak, MR | 2 |
| Siebelt, M | 1 |
| Waarsing, JH | 1 |
| Groen, HC | 1 |
| Müller, C | 1 |
| Koelewijn, SJ | 1 |
| de Blois, E | 1 |
| Verhaar, JA | 1 |
| de Jong, M | 1 |
| Weinans, H | 1 |
| Duarte, JH | 1 |
| Xu, C | 1 |
| Li, X | 1 |
| Song, J | 1 |
| Acar, N | 1 |
| Balkarli, H | 1 |
| Soyuncu, Y | 1 |
| Ozbey, O | 1 |
| Celik-Ozenci, C | 1 |
| Korkusuz, P | 1 |
| Ustunel, I | 1 |
| Saag, KG | 1 |
| Hu, H | 2 |
| Li, B | 1 |
| Zhang, Y | 2 |
| Liu, X | 1 |
| Cheng, T | 1 |
| Wang, Z | 1 |
| Giner, M | 1 |
| Rios, MJ | 1 |
| Montoya, MJ | 1 |
| Vázquez, MA | 1 |
| Miranda, C | 1 |
| Pérez-Cano, R | 1 |
| Song, H | 1 |
| Hayami, T | 1 |
| Zhuo, Y | 1 |
| Wesolowski, GA | 1 |
| Pickarski, M | 1 |
| Duong, LT | 1 |
| Maksymowych, WP | 1 |
| Seo, SK | 1 |
| Yang, HI | 1 |
| Lim, KJ | 1 |
| Jeon, YE | 1 |
| Choi, YS | 1 |
| Cho, S | 1 |
| Lee, BS | 1 |
| He, D | 1 |
| Yin, M | 1 |
| Luo, Y | 1 |
| Wei, Q | 1 |
| Zhu, S | 1 |
| Chen, K | 1 |
| Lan, Y | 1 |
| Jiang, R | 1 |
| Hu, J | 1 |
| Ding, M | 1 |
| Danielsen, CC | 1 |
| Hvid, I | 1 |
| Neogi, T | 1 |
| Nevitt, MC | 1 |
| Ensrud, KE | 1 |
| Bauer, D | 1 |
| Felson, DT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Placebo Controlled Trial Testing The Effect of Zoledronic Acid on Hip Osteoarthritis[NCT04303026] | Phase 3 | 70 participants (Anticipated) | Interventional | 2020-03-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for alendronate and Osteoarthritis
| Article | Year |
|---|---|
[Research progress of protective effects of alendronate on articular cartilage in osteoarthritis].
Topics: Alendronate; Animals; Anterior Cruciate Ligament; Bone Density Conservation Agents; Bone Remodeling; | 2012 |
2 trials available for alendronate and Osteoarthritis
| Article | Year |
|---|---|
Changes in serum levels of cartilage oligomeric matrix protein after estrogen and alendronate therapy in postmenopausal women.
Topics: Aged; Alendronate; Androstenes; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metab | 2012 |
The effect of alendronate on progression of spinal osteophytes and disc-space narrowing.
Topics: Aged; Alendronate; Bone Density Conservation Agents; Disease Progression; Female; Humans; Interverte | 2008 |
20 other studies available for alendronate and Osteoarthritis
| Article | Year |
|---|---|
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Therapeutic effect of alendronate in an experimental temporomandibular joint osteoarthritis.
Topics: Alendronate; Animals; Cartilage, Articular; Injections, Intra-Articular; Osteoarthritis; Rats; Rats, | 2023 |
Axial Compressive Loading Attenuates Early Osteoarthritis by Reducing Subchondral Bone Remodeling.
Topics: Alendronate; Animals; Bone Remodeling; Cartilage, Articular; Disease Models, Animal; Inflammation; M | 2023 |
Changes in the Subchondral Bone, Visfatin, and Cartilage Biomarkers after Pharmacological Treatment of Experimental Osteoarthritis with Metformin and Alendronate.
Topics: Alendronate; Animals; Biomarkers; Cartilage, Articular; Disease Models, Animal; Metformin; Mice; Nic | 2023 |
Effect of intra-articular injection of a hyaluronic acid-alendronate conjugate on post-traumatic osteoarthritis induced by destabilization of the medial meniscus in rats.
Topics: Alendronate; Animals; Cartilage, Articular; Disease Models, Animal; Hyaluronic Acid; Injections, Int | 2023 |
Specific inhibition of FAK signaling attenuates subchondral bone deterioration and articular cartilage degeneration during osteoarthritis pathogenesis.
Topics: Alendronate; Animals; Anterior Cruciate Ligament; Bone and Bones; Bone Remodeling; Cartilage, Articu | 2020 |
Early inhibition of subchondral bone remodeling slows load-induced posttraumatic osteoarthritis development in mice.
Topics: Alendronate; Animals; Bone Remodeling; Cartilage, Articular; Male; Mice; Mice, Inbred C57BL; Osteoar | 2021 |
Protective Effect of Alendronate on Lumbar Facet Degeneration in Ovariectomized Rats.
Topics: Alendronate; Animals; Bone and Bones; Bone Density; Cartilage, Articular; Chondrocytes; Female; Lumb | 2019 |
Synthesis and in vitro evaluation of bone-seeking superparamagnetic iron oxide nanoparticles as contrast agents for imaging bone metabolic activity.
Topics: Adult; Alendronate; Bone and Bones; Bone Density Conservation Agents; Contrast Media; Dextrans; Ferr | 2013 |
Inhibited osteoclastic bone resorption through alendronate treatment in rats reduces severe osteoarthritis progression.
Topics: Alendronate; Animals; Body Weight; Bone and Bones; Bone Resorption; Cartilage, Articular; Disease Pr | 2014 |
Osteoarthritis: alendronate treatment improves pathology in animal model of OA by blocking osteoclastic bone resorption.
Topics: Alendronate; Animals; Bone Resorption; Disease Progression; Male; Osteoarthritis; Osteoclasts | 2014 |
Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats.
Topics: Acid Phosphatase; Alendronate; Animals; Cartilage, Articular; Collagen Type I; Collagen Type X; Feed | 2015 |
The determination of apoptosis rates on articular cartilages of ovariectomized rats with and without alendronate treatment.
Topics: Alendronate; Animals; Apoptosis; Bone Density Conservation Agents; Cartilage, Articular; Disease Mod | 2016 |
Bisphosphonates for osteoarthritis prevention: "Holy Grail" or not?
Topics: Alendronate; Bone Density Conservation Agents; Diphosphonates; Humans; Osteoarthritis; Radiography; | 2008 |
[In vitro effect of alendronate on chondrocytes and articular cartilage and subchondral bone in rabbit anterior cruciate ligament transection model].
Topics: Alendronate; Animals; Anterior Cruciate Ligament; Cartilage, Articular; Cells, Cultured; Chondrocyte | 2009 |
Alendronate and raloxifene affect the osteoprotegerin/RANKL system in human osteoblast primary cultures from patients with osteoporosis and osteoarthritis.
Topics: Aged; Aged, 80 and over; Alendronate; Bone Density Conservation Agents; Bone Remodeling; Cells, Cult | 2011 |
Enhancement of subchondral bone quality by alendronate administration for the reduction of cartilage degeneration in the early phase of experimental osteoarthritis.
Topics: Absorptiometry, Photon; Alendronate; Animals; Bone and Bones; Bone Density; Bone Density Conservatio | 2011 |
Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.
Topics: Alendronate; Animals; Anterior Cruciate Ligament Injuries; Benzamides; Biomarkers; Bone Density Cons | 2012 |
Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation.
Topics: Alendronate; Animals; Arthritis, Experimental; Bone Density Conservation Agents; Drug Evaluation, Pr | 2012 |
Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.
Topics: Alendronate; Animals; Cartilage, Articular; Female; Immunohistochemistry; Osteoarthritis; Osteoporos | 2013 |
The effects of bone remodeling inhibition by alendronate on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis.
Topics: Alendronate; Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Remodelin | 2008 |