alendronate has been researched along with Giant Cell Tumor of Bone in 2 studies
alendronic acid : A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.
Giant Cell Tumor of Bone: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alendronate promotes apoptosis of the OCLs and it is related with the expression of the Fas gene." | 1.31 | Apoptosis of osteoclast-like cells induced by alendronate is related to Fas gene expression. ( Wang, XM; Yang, ZP; Yu, SF, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, YY | 1 |
| Huang, L | 1 |
| Lee, KM | 1 |
| Xu, JK | 1 |
| Zheng, MH | 1 |
| Kumta, SM | 1 |
| Wang, XM | 1 |
| Yu, SF | 1 |
| Yang, ZP | 1 |
2 other studies available for alendronate and Giant Cell Tumor of Bone
| Article | Year |
|---|---|
Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone.
Topics: Alendronate; Antineoplastic Agents; Apoptosis; Bone Neoplasms; Diphosphonates; DNA Fragmentation; DN | 2004 |
Apoptosis of osteoclast-like cells induced by alendronate is related to Fas gene expression.
Topics: Alendronate; Antibodies, Monoclonal; Apoptosis; Bone Resorption; Cell Adhesion; Cell Nucleus; Chroma | 2000 |